2013
Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment
Schottenfeld RS, Chawarski MC, Cubells JF, George TP, Lappalainen J, Kosten TR. Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. Drug And Alcohol Dependence 2013, 136: 36-42. PMID: 24462581, DOI: 10.1016/j.drugalcdep.2013.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlcohol DeterrentsAlcoholismAllelesBuprenorphineCocaine-Related DisordersData Interpretation, StatisticalDisulfiramDNADouble-Blind MethodDrug Therapy, CombinationFemaleGenotypeHumansMaleMiddle AgedNarcotic AntagonistsOpioid-Related DisordersPharmacogeneticsPolymerase Chain ReactionSample SizeTreatment OutcomeYoung AdultConceptsUrine testsCocaine useMechanism of actionCocaine dependenceClinical trialsWeeks abstinencePlacebo-controlled clinical trialEfficacy of disulfiramPharmacogenetics of responseDouble-blind treatmentBuprenorphine maintenance treatmentRandomized clinical trialsOpioid-dependent participantsT allele carriersFrequent cocaine useDopamine β-hydroxylaseBuprenorphine treatmentPrimary outcomeTreat comparisonMaintenance treatmentPharmacogenetic interactionsTreatment responseTT genotypeCocaine abstinenceConsecutive weeks
2000
Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial
George T, Chawarski M, Pakes J, Carroll K, Kosten T, Schottenfeld R. Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial. Biological Psychiatry 2000, 47: 1080-1086. PMID: 10862808, DOI: 10.1016/s0006-3223(99)00310-8.Peer-Reviewed Original ResearchConceptsBuprenorphine-maintained subjectsCocaine dependenceUrine testsBuprenorphine-maintained patientsEffect of disulfiramContinuous cocaine abstinenceCocaine-dependent subjectsDrug use severityBuprenorphine maintenancePlacebo treatmentDisulfiram groupPlaceboCocaine abstinencePotential efficacyDependent subjectsBaseline measuresDisulfiramNumber of daysWeeksHigh rateSubjectsTrialsPreliminary trialTreatmentPreliminary study