2000
Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects
Winther L, Saleem R, McCance-Katz E, Rosen M, Hameedi F, Pearsall H, Jatlow P, Kosten T, Woods S. Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects. The American Journal Of Drug And Alcohol Abuse 2000, 26: 47-59. PMID: 10718163, DOI: 10.1081/ada-100100590.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateGlutamate release inhibitorEffects of lamotrigineCocaine-dependent volunteersMood States questionnaireLamotrigine pretreatmentAcute pretreatmentCardiovascular responsesRelaxing effectRelease inhibitorIntranasal cocaineStudy daysDrug effectsLamotriginePredetermined time intervalsCocainePlaceboHuman subjectsState QuestionnaireExperimental sessionsSubjectsMood effectsBehavioral responsesSubjective ratings
1999
The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers
Rosen M, Kosten T, Kreek M. The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers. Biological Psychiatry 1999, 45: 1636-1645. PMID: 10376126, DOI: 10.1016/s0006-3223(98)00259-5.Peer-Reviewed Original ResearchConceptsWeeks of treatmentDrug effectsStrongest drug effectsOpioid antagonist naltrexoneActive naltrexoneNaltrexone treatmentNaltrexone maintenanceAntagonist naltrexoneHealthy subjectsHealthy volunteersWeek 1Week 2Cortisol levelsYohimbineWeek 5PlaceboPreclinical researchNaltrexoneAlters sensitivityEffect of pretreatmentWeeksAntagonistTreatmentStress responsivenessSubjectsInteractions of Cocaine with Nimodipine: A Brief Report
Kosten T, Woods S, Rosen M, Pearsall H. Interactions of Cocaine with Nimodipine: A Brief Report. American Journal On Addictions 1999, 8: 77-81. PMID: 10189518, DOI: 10.1080/105504999306117.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalcium Channel BlockersCocaineDose-Response Relationship, DrugDouble-Blind MethodDrug InteractionsFemaleHumansMaleMiddle AgedNimodipine
1998
The effect of lamotrigine on naloxone-precipitated opiate withdrawal
Rosen M, Pearsall H, Kosten T. The effect of lamotrigine on naloxone-precipitated opiate withdrawal. Drug And Alcohol Dependence 1998, 52: 173-176. PMID: 9800147, DOI: 10.1016/s0376-8716(98)00057-x.Peer-Reviewed Original Research
1997
Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients
Rosen M, Pearsall H, Woods S, Kosten T. Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients. Journal Of Substance Use And Addiction Treatment 1997, 14: 149-154. PMID: 9258859, DOI: 10.1016/s0740-5472(96)00157-2.Peer-Reviewed Original ResearchDose Dependent Effects of Yohimbine on Methadone Maintained Patients
Hameedi F, Woods S, Rosen M, Pearsall H, Kosten T. Dose Dependent Effects of Yohimbine on Methadone Maintained Patients. The American Journal Of Drug And Alcohol Abuse 1997, 23: 327-333. PMID: 9143642, DOI: 10.3109/00952999709040950.Peer-Reviewed Original ResearchTreatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T
Kosten T, Rosen M, McMahon T, Bridge T, O'malley S, Pearsall R, O'connor P. Treatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T. The American Journal Of Drug And Alcohol Abuse 1997, 23: 543-553. PMID: 9366972, DOI: 10.3109/00952999709016894.Peer-Reviewed Original Research
1996
A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal
Rosen M, McMahon T, Woods S, Pearsall H, Kosten T. A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal. European Journal Of Pharmacology 1996, 307: 251-257. PMID: 8836612, DOI: 10.1016/0014-2999(96)00249-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultDextromethorphanDouble-Blind MethodFemaleHumansMaleNaloxonePilot ProjectsSubstance Withdrawal SyndromeConceptsNaloxone-precipitated opiate withdrawalOpiate withdrawalOpiate-dependent subjectsPre-clinical studiesConsiderable inter-individual variabilityPretreatment 1 hInter-individual variabilityIntramuscular naloxoneDextromethorphanPilot studyWithdrawal measuresPlaceboNaloxoneMethadoneWithdrawalSubjectsDifferent daysRandomized design
1995
Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans
Hameedi F, Rosen M, McCance-Katz E, McMahon T, Price L, Jatlow P, Woods S, Kosten T. Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans. Biological Psychiatry 1995, 37: 560-563. PMID: 7619981, DOI: 10.1016/0006-3223(94)00361-6.Peer-Reviewed Original ResearchOpiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT)
Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.Peer-Reviewed Original ResearchConceptsRegional brain functionOpiate withdrawal signsSingle Photon Emission Computerized TomographyHealthy subjectsNaloxone administrationOpiate withdrawalOpiate dependenceBrain functionParietal cortexHexamethylpropyleneamine oximeWithdrawal signsNaloxone effectChronic opiate dependencePlacebo-controlled studyRegional alterationsComparison of patientsMethadone-maintained patientsRegional cerebral perfusionPhoton Emission Computerized TomographyOpiate-dependent patientsRight temporal cortexRight parietal cortexFunctional brain imaging technologiesSingle photon emissionEmission computerized tomography
1993
Effects of Acute Buprenorphine on Responses to Intranasal Cocaine: A Pilot Study
Rosen M, Pearsall H, McDougle C, Price L, Woods S, Kosten T. Effects of Acute Buprenorphine on Responses to Intranasal Cocaine: A Pilot Study. The American Journal Of Drug And Alcohol Abuse 1993, 19: 451-464. PMID: 8273766, DOI: 10.3109/00952999309001634.Peer-Reviewed Original Research
1992
A pilot trial of gepirone vs. placebo in the treatment of cocaine dependency.
Jenkins S, Warfield N, Blaine J, Cornish J, Ling W, Rosen M, Urschel H, Wesson D, Ziedonis D. A pilot trial of gepirone vs. placebo in the treatment of cocaine dependency. Psychopharmacology Bulletin 1992, 28: 21-6. PMID: 1609038.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsCocaineDouble-Blind MethodFemaleHumansMalePilot ProjectsPlacebosPyrimidinesSubstance-Related DisordersConceptsGlobal Assessment ScaleAddiction Severity IndexClinical Global Impressions-Global Improvement ScaleCocaine useGlobal Improvement ScaleHamilton Rating ScaleHamilton Anxiety ScaleEvaluable patientsAdverse eventsMean dosePilot trialOpiate abuseImprovement ScaleInterim analysisTreatment groupsAssessment ScaleCocaine dependenceFavorable trendOlder ageCCS scoresStudy outcomesRating ScaleGepironeTreatment measuresSeverity Index