1994
SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine
van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowRegional cerebral blood flow alterationsCerebral blood flow alterationsHexamethyl propylene amine oximeOpiate-induced analgesiaBlood flow alterationsSeverity of withdrawalCerebral blood flowOpiate-dependent patientsAnterior cingulate regionsAnterior cingulate cortexSingle photon emissionPlacebo administrationAmine oximeOpiate withdrawalRCBF ratiosWithdrawal severityBlood flowCingulate cortexCingulate regionsSignificant negative correlationBuprenorphineNaltrexonePlaceboPatientsBuprenorphine: duration of blockade of effects of intramuscular hydromorphone
Rosen M, Wallace E, McMahon T, Pearsall H, Woods S, Price L, Kosten T. Buprenorphine: duration of blockade of effects of intramuscular hydromorphone. Drug And Alcohol Dependence 1994, 35: 141-149. PMID: 7519977, DOI: 10.1016/0376-8716(94)90121-x.Peer-Reviewed Original Research
1993
Effects of Acute Buprenorphine on Responses to Intranasal Cocaine: A Pilot Study
Rosen M, Pearsall H, McDougle C, Price L, Woods S, Kosten T. Effects of Acute Buprenorphine on Responses to Intranasal Cocaine: A Pilot Study. The American Journal Of Drug And Alcohol Abuse 1993, 19: 451-464. PMID: 8273766, DOI: 10.3109/00952999309001634.Peer-Reviewed Original Research
1992
Buprenorphine for cocaine and opiate dependence.
Kosten T, Rosen M, Schottenfeld R, Ziedonis D. Buprenorphine for cocaine and opiate dependence. Psychopharmacology Bulletin 1992, 28: 15-9. PMID: 1609037.Peer-Reviewed Original ResearchMeSH KeywordsBuprenorphineClinical Trials as TopicCocaineHumansOpioid-Related DisordersSubstance-Related DisordersConceptsCocaine abuseMixed opioid agonist/antagonistOpioid agonist/antagonistPreliminary human studiesAgonists/antagonistsBuprenorphine treatmentOpioid dependenceMethadone maintenanceClinical trialsConcurrent dependencePreclinical studiesCocaine effectsBuprenorphineHuman studiesPlace preferenceChallenge studiesCocaineMethadoneTreatmentTrialsAbuseDose dependenceOpioidsAntagonistDaily
1991
Buprenorphine: Beyond Methadone?
Rosen M, Kosten T. Buprenorphine: Beyond Methadone? Psychiatric Services 1991, 42: 347-349. PMID: 2050347, DOI: 10.1176/ps.42.4.347.Peer-Reviewed Original ResearchConceptsConnecticut Mental Health CenterHuman immunodeficiency virusPromising new treatmentMental health centersSubstance abuse treatmentDepartment of PsychiatryAbuse of cocaineIntravenous heroinImmunodeficiency virusHealth centersYale University SchoolNew treatmentsAbuse treatmentGuest authorsDrug addictsDr. RosenUniversity SchoolRisk-taking behaviorTreatmentMethadoneResearch UnitHeroinCocaine