1996
Acute cocaine effects on absolute cerebral blood flow
Wallace E, Wisniewski G, Zubal G, vanDyck C, Pfau S, Smith E, Rosen M, Sullivan M, Woods S, Kosten T. Acute cocaine effects on absolute cerebral blood flow. Psychopharmacology 1996, 128: 17-20. PMID: 8944401, DOI: 10.1007/s002130050104.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCerebrovascular CirculationCocaineHumansMaleNarcoticsOrganotechnetium CompoundsOximesTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonConceptsRelative cerebral blood flowCerebral blood flowBlood flowWhole-brain blood flowAbsolute cerebral blood flowBrain blood flowBlood flow changesAcute cocaine effectsRelative blood flow changesCocaine effectsMean decreaseCocaine useCocaine usersSignificant decreaseFlow changesMicrosphere modelVasoconstrictionStroke
1995
Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT)
Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBasal GangliaBlood PressureBrainCerebral CortexDouble-Blind MethodFemaleGyrus CinguliHumansMaleMethadoneNaloxoneOpioid-Related DisordersSubstance Withdrawal SyndromeThalamusTomography, Emission-Computed, Single-PhotonConceptsRegional brain functionOpiate withdrawal signsSingle Photon Emission Computerized TomographyHealthy subjectsNaloxone administrationOpiate withdrawalOpiate dependenceBrain functionParietal cortexHexamethylpropyleneamine oximeWithdrawal signsNaloxone effectChronic opiate dependencePlacebo-controlled studyRegional alterationsComparison of patientsMethadone-maintained patientsRegional cerebral perfusionPhoton Emission Computerized TomographyOpiate-dependent patientsRight temporal cortexRight parietal cortexFunctional brain imaging technologiesSingle photon emissionEmission computerized tomography
1994
SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine
van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineFemaleGyrus CinguliHumansMaleNaltrexonePlacebosRegional Blood FlowSeverity of Illness IndexSubstance Withdrawal SyndromeSubstance-Related DisordersThalamusTomography, Emission-Computed, Single-PhotonConceptsRegional cerebral blood flowRegional cerebral blood flow alterationsCerebral blood flow alterationsHexamethyl propylene amine oximeOpiate-induced analgesiaBlood flow alterationsSeverity of withdrawalCerebral blood flowOpiate-dependent patientsAnterior cingulate regionsAnterior cingulate cortexSingle photon emissionPlacebo administrationAmine oximeOpiate withdrawalRCBF ratiosWithdrawal severityBlood flowCingulate cortexCingulate regionsSignificant negative correlationBuprenorphineNaltrexonePlaceboPatients