The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers
Rosen M, Kosten T, Kreek M. The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers. Biological Psychiatry 1999, 45: 1636-1645. PMID: 10376126, DOI: 10.1016/s0006-3223(98)00259-5.Peer-Reviewed Original ResearchConceptsWeeks of treatmentDrug effectsStrongest drug effectsOpioid antagonist naltrexoneActive naltrexoneNaltrexone treatmentNaltrexone maintenanceAntagonist naltrexoneHealthy subjectsHealthy volunteersWeek 1Week 2Cortisol levelsYohimbineWeek 5PlaceboPreclinical researchNaltrexoneAlters sensitivityEffect of pretreatmentWeeksAntagonistTreatmentStress responsivenessSubjects