2024
COCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. COCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER. Drug And Alcohol Dependence 2024, 260: 110081. DOI: 10.1016/j.drugalcdep.2023.110081.Peer-Reviewed Original ResearchStructural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellumIntrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders
Vaccaro A, Lacadie C, Potenza M. Intrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders. Addictive Behaviors 2024, 155: 108027. PMID: 38581751, PMCID: PMC11273263, DOI: 10.1016/j.addbeh.2024.108027.Peer-Reviewed Original ResearchConceptsCocaine use disorderPosterior cingulate cortexCue reactivityBehavioral addictionsUse disorderGambling disorderPosterior cingulatePosterior cingulate cortex connectivityHealthy comparison subjectsIntrinsic connectivity distributionIntervention developmentCocaine cuesFMRI taskAddictive disordersCingulate cortexComparison subjectsNeurobiological foundationsSad videosDecreased connectivityFunctional connectivityCocainePost hoc analysisAddictionRelevant to maintenanceGamblingCocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder. The American Journal Of Drug And Alcohol Abuse 2024, 50: 345-356. PMID: 38551365, PMCID: PMC11305926, DOI: 10.1080/00952990.2024.2318585.Peer-Reviewed Original ResearchGray-matter volumeSelf-administer cocaineSelf-administration behaviorCocaine use disorderSelf-administrationGray-matterFrontal cortexUse disorderCocaine self-administration behaviorSelf-administered cocaine infusionsCocaine self-administrationSelf-administration paradigmInfusions self-administeredSelf-report assessmentsCortical brain regionsStructural MRI dataFR1 scheduleInsular thicknessCocaine infusionsPredisposing vulnerabilitiesCocaine consumptionCocaine useBrain regionsBilateral regionsLimbic system
2023
Diagnostic group differences and exploratory sex differences in intrinsic connectivity during fMRI Stroop in individuals with and without cocaine use disorder
Zakiniaeiz Y, Lacadie C, Macdonald-Gagnon G, DeVito E, Potenza M. Diagnostic group differences and exploratory sex differences in intrinsic connectivity during fMRI Stroop in individuals with and without cocaine use disorder. Drug And Alcohol Dependence 2023, 251: 110962. PMID: 37716288, PMCID: PMC10557108, DOI: 10.1016/j.drugalcdep.2023.110962.Peer-Reviewed Original ResearchConceptsCocaine use disorderCognitive controlStroop performanceIntrinsic connectivityStroop task performanceFMRI Stroop taskDiagnostic groupsUse disordersDiagnostic group differencesMain effectHealthy comparison subjectsStroop effectStroop taskBehavioral resultsTask performanceFrontal gyrusIntrinsic connectivity distributionPrefrontal cortexAuditory areasGroup differencesBrain connectivityCingulate gyrusStroopBehavioral differencesHC groupDiscriminating cocaine use from other sympathomimetics using wearable electrocardiographic (ECG) sensors
Angarita G, Pittman B, Nararajan A, Mayerson T, Parate A, Marlin B, Gueorguieva R, Potenza M, Ganesan D, Malison R. Discriminating cocaine use from other sympathomimetics using wearable electrocardiographic (ECG) sensors. Drug And Alcohol Dependence 2023, 250: 110898. PMID: 37523916, PMCID: PMC10905422, DOI: 10.1016/j.drugalcdep.2023.110898.Peer-Reviewed Original ResearchConnectome-based prediction of craving in gambling disorder and cocaine use disorder
Antons S, Yip S, Lacadie C, Dadashkarimi J, Scheinost D, Brand M, Potenza M. Connectome-based prediction of craving in gambling disorder and cocaine use disorder. Dialogues In Clinical Neuroscience 2023, 25: 33-42. PMID: 37190759, PMCID: PMC10190201, DOI: 10.1080/19585969.2023.2208586.Peer-Reviewed Original ResearchConceptsCocaine use disorderGambling disorderBehavioral addictionsCue-reactivity taskComponents of memoryGeneral neural mechanismCommon neural networkFunctional magnetic resonanceMedial frontal regionsDefault mode networkFeatures of addictionAutobiographical memoryValence ratingsMeta-analytic dataPrefrontal regionsNeural mechanismsPrefrontal cortexFronto-parietalFrontal regionsMotor imageryMotor/Diverse sampleLimbic networkNeural connectivityCraving
2022
Glutamatergic Agents for the Treatment of Cocaine Use Disorder
Hadizadeh H, Flores J, Mayerson T, Worhunsky P, Potenza M, Angarita G. Glutamatergic Agents for the Treatment of Cocaine Use Disorder. Current Behavioral Neuroscience Reports 2022, 9: 101-112. DOI: 10.1007/s40473-022-00252-1.Peer-Reviewed Original ResearchCocaine use disorderRoute of administrationGlutamatergic systemSafety profileNovel agentsUse disordersMetabotropic glutamate receptor 5 antagonistNewer beta-lactam agentsAMPA/kainate receptorsTreatment of CUDBeta-lactam agentsGood safety profileMetabotropic glutamate receptorsPromising preclinical dataReceptors/transportersChronic cocaine useGLT-1 transporterBeta-lactam antibioticsOngoing trialsPreclinical supportGlutamatergic agentsGlutamate neurotransmissionPreclinical dataClinical trialsGlutamate receptorsNovel Pharmacological Agents for the Treatment of Cocaine Use Disorder
Hadizadeh H, Flores J, Nunes E, Mayerson T, Potenza M, Angarita G. Novel Pharmacological Agents for the Treatment of Cocaine Use Disorder. Current Behavioral Neuroscience Reports 2022, 9: 27-46. DOI: 10.1007/s40473-022-00246-z.Peer-Reviewed Original ResearchCocaine use disorderNovel pharmacological agentsUse disordersCocaine vaccinePharmacological agentsClinical supportNarrative reviewAlpha-adrenergic antagonistKappa-opioid receptorsCorticotropin-releasing factorCentral nervous systemPurpose of reviewClinical evidenceGlutamatergic agentsSerotonergic agentsCholinergic agentsOrexin antagonistsNeurobiological targetsDopamine pathwayArousal pathwayNervous systemExtension studyPromising agentCapacity of cocaineDisorders
2018
fMRI Stroop and behavioral treatment for cocaine-dependence: Preliminary findings in methadone-maintained individuals
DeVito EE, Kober H, Carroll KM, Potenza MN. fMRI Stroop and behavioral treatment for cocaine-dependence: Preliminary findings in methadone-maintained individuals. Addictive Behaviors 2018, 89: 10-14. PMID: 30240978, PMCID: PMC6374034, DOI: 10.1016/j.addbeh.2018.09.005.Peer-Reviewed Original ResearchConceptsCocaine use disorderStroop effectBehavioral treatmentComputer-based cognitive behavioral therapyColor-word Stroop taskCognitive neuroscience methodsCognitive behavioral therapyCocaine-dependent individualsCocaine abstinenceCognitive controlStroop taskNeuroscience methodsMethadone-maintained individualsTreatment abstinenceLingual gyrusStroopCingulate gyrusUse disordersCocaine usersTreatment mechanismsAbstinenceBetter treatment outcomesPreliminary findingsGyrusParticipants
2017
Chapter 34 Stroop, Cocaine Dependence, and Intrinsic Connectivity
Mitchell M, Potenza M. Chapter 34 Stroop, Cocaine Dependence, and Intrinsic Connectivity. 2017, 331-339. DOI: 10.1016/b978-0-12-803750-8.00034-8.ChaptersCognitive controlUnderlying neural mechanismsCocaine dependenceCocaine use disorderCognitive interferenceNeurocognitive tasksResponse inhibitionNeural mechanismsIntrinsic connectivityPsychopathological conditionsStroopBrain circuitryDistinct networksBody of literatureTreatment outcomesSuch topicsTaskAddictionDisordersCircuitryDifficultiesConnectivityContext