2024
The Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews
Kitaneh R, Jalilian-Khave L, Ysrayl B, Borelli A, Funaro M, Potenza M, Angarita G. The Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews. Current Behavioral Neuroscience Reports 2024, 11: 164-181. DOI: 10.1007/s40473-024-00278-7.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorder symptomsTreatment of attention-deficit hyperactivity disorderSeverity of ADHD symptomsAttention-deficit hyperactivity disorderManagement of attention-deficit/hyperactivity disorderOutcomes of attention-deficit/hyperactivity disorderOverview of systematic reviewsADHD symptomsSerum vitamin D levelsHyperactivity disorderInclusion criteriaMeta-analysesVitamin D levelsBrain regionsMaternal serum vitamin D levelsPrenatal vitamin D levelsAssociated with improvementsNeurotransmitter regulationRisk of offspringVitamin D supplementationD levelsWell-powered randomized clinical trialsSystematic literature searchSummaryThe literatureEfficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder
Ni H, Wang H, Ma X, Li S, Liu C, Song X, Potenza M, Dong G. Efficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder. JAMA Network Open 2024, 7: e2416684. PMID: 38888924, PMCID: PMC11185988, DOI: 10.1001/jamanetworkopen.2024.16684.Peer-Reviewed Original ResearchConceptsInternet gaming disorderDSM-5-TRProgressive muscle relaxationMindfulness meditationProgressive muscle relaxation groupNeural mechanismsGaming cravingsAddiction severityDecreased cravingFunctional connectivityAssociated with decreased brain activitySeverity of internet gaming disorderInternet gaming disorder severityTreating Internet Gaming DisorderBlood oxygen level-dependent signalCue-craving taskMedial frontal gyrusPotential neural mechanismsProgressive muscle relaxation trainingBilateral lentiform nucleusFrontal gyrusIncreased mindfulnessBrain measuresGaming disorderBrain regionsSubstance use and spine density: a systematic review and meta-analysis of preclinical studies
Oliva H, Prudente T, Nunes E, Cosgrove K, Radhakrishnan R, Potenza M, Angarita G. Substance use and spine density: a systematic review and meta-analysis of preclinical studies. Molecular Psychiatry 2024, 29: 2873-2885. PMID: 38561468, DOI: 10.1038/s41380-024-02519-3.Peer-Reviewed Original ResearchSpine densityPrefrontal cortexSubstance useDrug self-administrationHippocampal spine densityEffects of cocaineSubstance use disordersConvergence of findingsSpine density changesSubstances of abuseMeta-analysis of preclinical studiesNucleus accumbensBehavioral sensitizationSelf-administrationBrain mechanismsPreclinical studiesBrain regionsMorphine effectsSynaptic density changesMeta-analysisAmphetamineSynaptic densityCocaineModerate-to-highCortexCocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder. The American Journal Of Drug And Alcohol Abuse 2024, 50: 345-356. PMID: 38551365, PMCID: PMC11305926, DOI: 10.1080/00952990.2024.2318585.Peer-Reviewed Original ResearchGray-matter volumeSelf-administer cocaineSelf-administration behaviorCocaine use disorderSelf-administrationGray-matterFrontal cortexUse disorderCocaine self-administration behaviorSelf-administered cocaine infusionsCocaine self-administrationSelf-administration paradigmInfusions self-administeredSelf-report assessmentsCortical brain regionsStructural MRI dataFR1 scheduleInsular thicknessCocaine infusionsPredisposing vulnerabilitiesCocaine consumptionCocaine useBrain regionsBilateral regionsLimbic systemNeural correlates of altered emotional responsivity to infant stimuli in mothers who use substances
McCurdy L, Yip S, Worhunsky P, Zhai Z, Kim S, Strathearn L, Potenza M, Mayes L, Rutherford H. Neural correlates of altered emotional responsivity to infant stimuli in mothers who use substances. Journal Of Psychiatric Research 2024, 171: 126-133. PMID: 38277872, PMCID: PMC10922955, DOI: 10.1016/j.jpsychires.2024.01.024.Peer-Reviewed Original ResearchConceptsResponses to infant stimuliInfant stimuliMaternal behaviorAffective processesBrain regionsPsychological processesEmotional responsesFunctional magnetic resonance imagingPotential neural targetsInfant emotional expressionsMaternal emotional responsivenessSubstance-use statusAssociated with difficultiesSocial-emotional developmentInfant social-emotional developmentMaternal substance useInfant facesCognitive processesImprove child outcomesEmotional expressionEmotional intensityNeural targetsSubstance useGroups of mothersChild outcomesrTMS effects on urges and severity of tobacco use disorder operate independently of a retrieval-extinction component and involve frontal-striatal pathways
Li S, Ma X, Chen H, Wang M, Zheng Y, Yang B, Ni H, Potenza M, Dong G. rTMS effects on urges and severity of tobacco use disorder operate independently of a retrieval-extinction component and involve frontal-striatal pathways. Journal Of Affective Disorders 2024, 349: 21-31. PMID: 38190858, DOI: 10.1016/j.jad.2024.01.048.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexRepetitive transcranial magnetic stimulationSmoking cravingFunctional connectivityTobacco use disorderBrain regionsRetrieval-extinction procedureLeft dorsolateral prefrontal cortexSimilar neural correlatesFrontal-striatal pathwaysStandard repetitive transcranial magnetic stimulationUse disordersMedial frontal gyrusIncreased functional connectivitySham repetitive transcranial magnetic stimulationExecutive controlSmoking cuesNeural correlatesTranscranial magnetic stimulationBrain responsesFrontal gyrusGreater activationLess activationSmoking urgesBilateral insula
2023
Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential agePotential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions
Mestre-Bach G, Potenza M. Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions. Nutrients 2023, 15: 827. PMID: 36839185, PMCID: PMC9962023, DOI: 10.3390/nu15040827.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInternet gaming disorderGambling disorderVentral striatumBehavioral addictionsBinge Eating DisorderReward processingEating DisordersGaming disorderReward systemTreatment implicationsBrain regionsBrain changesTreatment-related changesAddictionDisordersBingePotential biological markersPossible biomarkersBiological markersMore evidenceSpecific roleProcessingInterventionImplicationsCircuitry
2022
Neuromodulation treatments of problematic use of the Internet
Xu L, Geng X, Zhang J, Guo X, Potenza M, Zhang J. Neuromodulation treatments of problematic use of the Internet. Current Opinion In Behavioral Sciences 2022, 48: 101215. DOI: 10.1016/j.cobeha.2022.101215.Peer-Reviewed Original ResearchProblematic useBrain circuitsTranscranial direct current stimulationDorsolateral prefrontal cortexDirect current stimulationRepetitive transcranial magnetic stimulationExecutive controlNegative emotionsStimulus contextTranscranial magnetic stimulationAddictive behaviorsPrefrontal cortexCurrent stimulationAddiction severityBrain regionsMagnetic stimulationNeuromodulation treatmentsInvasive stimulationEmotionsCausal relationshipCravingFunctioningRigorous experimentsAddictionCortex
2019
How Spirituality May Mitigate Against Stress and Related Mental Disorders: a Review and Preliminary Neurobiological Evidence
McClintock C, Worhunsky P, Balodis I, Sinha R, Miller L, Potenza M. How Spirituality May Mitigate Against Stress and Related Mental Disorders: a Review and Preliminary Neurobiological Evidence. Current Behavioral Neuroscience Reports 2019, 6: 253-262. DOI: 10.1007/s40473-019-00195-0.Peer-Reviewed Original ResearchBrain mechanismsStress processingSelf-referential processingFunctional magnetic resonance imaging (fMRI) dataPotential brain mechanismsSpecific brain mechanismsImportant resilience factorMental disordersPreliminary fMRI dataStress-related psychopathologyMechanisms of psychopathologyDefault mode networkStress-related mental disordersCognitive processingNeurobiological evidenceNeural mechanismsNeural responsesNeuroscientific researchResilience factorsMagnetic resonance imaging dataNeural circuitryFMRI dataStress responsivityBrain regionsAcute stress
2018
Neurocognitive Mechanisms in Compulsive Sexual Behavior Disorder
Kowalewska E, Grubbs J, Potenza M, Gola M, Draps M, Kraus S. Neurocognitive Mechanisms in Compulsive Sexual Behavior Disorder. Current Sexual Health Reports 2018, 10: 255-264. DOI: 10.1007/s11930-018-0176-z.Peer-Reviewed Original ResearchCompulsive sexual behavior disorderCompulsive sexual behaviorSexual behavior disorderBrain regionsBehavior disorderReviewThe current reviewKey brain regionsNeurocognitive mechanismsSexual behaviorRecent FindingsTo dateImpulse control disordersNeurobiological mechanismsBehavioral addictionsGaming addictionNeuroscience researchTemporal cortexAltered functioningImpulse dyscontrolPrevious researchFuture researchAddictionICD-11World Health OrganizationNucleus accumbensDisorders
2014
Biological Underpinning of Behavioural Addictions and Management Implications
Yau Y, Leeman R, Potenza M. Biological Underpinning of Behavioural Addictions and Management Implications. 2014, 1411-1442. DOI: 10.1007/978-88-470-5322-9_71.ChaptersBehavioral addictionsCue-induced cravingNon-substance addictionVideo game playPresent chapter reviewsMaladaptive engagementNeurocircuitry levelImpaired inhibitionFrontal areasBrain regionsMultiple domainsNeurochemical levelsBiological underpinningsMesolimbic dopaminergic pathwayAddictionGenetic overlapArea of researchChapter reviewsHistory evidenceInternet useDopaminergic pathwaysPsychopathologyCravingGamblingEatingGeneralized fMRI Activation Detection Via Bayesian Magnitude Change Point Model
Lian Z, Lv J, Xing J, Li X, Jiang X, Zhu D, Xu J, Potenza M, Liu T, Zhang J. Generalized fMRI Activation Detection Via Bayesian Magnitude Change Point Model. 2014, 21-24. DOI: 10.1109/isbi.2014.6867799.Peer-Reviewed Original ResearchActivation patternsBrain activation patternsTask-based fMRI datasetsBrain mapping fieldDifferent brain regionsActivation detection methodsTemporal activation patternsGeneral linear modelFMRI signalsFMRI datasetsBrain regionsTask periodPopulation of subjectsGeneralized activationCortical landmarksSpatial activationChange-point modelMapping fieldPoint model