1997
Addition of desipramine to serotonin reuptake inhibitors in treatment- resistant obsessive-compulsive disorder
Barr LC, Goodman WK, Anand A, McDougle CJ, Price LH. Addition of desipramine to serotonin reuptake inhibitors in treatment- resistant obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 1293-1295. PMID: 9286191, DOI: 10.1176/ajp.154.9.1293.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsReuptake inhibitorsObsessive-compulsive disorderObsessive-compulsive symptomsTreatment-resistant obsessive-compulsive disorderDouble-blind studyNorepinephrine reuptake inhibitorsReuptake of norepinephrineSerotonin reuptake inhibitorsAddition of desipraminePlacebo groupSuperior efficacyDepressive symptomsDesipramineSymptomsSignificant differencesPatientsTreatmentInhibitorsDisordersPlaceboNorepinephrineClomipramineReuptakeWeeks
1994
Tryptophan Depletion in Patients With Obsessive-Compulsive Disorder Who Respond to Serotonin Reuptake Inhibitors
Barr LC, Goodman WK, McDougle CJ, Delgado PL, Heninger GR, Charney DS, Price LH. Tryptophan Depletion in Patients With Obsessive-Compulsive Disorder Who Respond to Serotonin Reuptake Inhibitors. JAMA Psychiatry 1994, 51: 309-317. PMID: 8161291, DOI: 10.1001/archpsyc.1994.03950040053007.Peer-Reviewed Original ResearchConceptsShort-term tryptophan depletionSerotonin reuptake inhibitorsTryptophan depletionReuptake inhibitorsObsessive-compulsive disorderFree plasma tryptophan levelsPlacebo-controlled cross-over designLow tryptophan dietPlasma tryptophan levelsAmino acid drinkCross-over designDepression ratingsDepressive symptomsSymptom reductionAcid drinkTryptophan levelsDSM-IIIPatientsNext morningCompulsive symptomsSymptomsDisordersDietInhibitorsDrinks