1997
Addition of desipramine to serotonin reuptake inhibitors in treatment- resistant obsessive-compulsive disorder
Barr LC, Goodman WK, Anand A, McDougle CJ, Price LH. Addition of desipramine to serotonin reuptake inhibitors in treatment- resistant obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 1293-1295. PMID: 9286191, DOI: 10.1176/ajp.154.9.1293.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsReuptake inhibitorsObsessive-compulsive disorderObsessive-compulsive symptomsTreatment-resistant obsessive-compulsive disorderDouble-blind studyNorepinephrine reuptake inhibitorsReuptake of norepinephrineSerotonin reuptake inhibitorsAddition of desipraminePlacebo groupSuperior efficacyDepressive symptomsDesipramineSymptomsSignificant differencesPatientsTreatmentInhibitorsDisordersPlaceboNorepinephrineClomipramineReuptakeWeeks
1995
Lack of efficacy of clozapine monotherapy in refractory obsessive- compulsive disorder
McDougle CJ, Barr LC, Goodman WK, Pelton GH, Aronson SC, Anand A, Price LH. Lack of efficacy of clozapine monotherapy in refractory obsessive- compulsive disorder. American Journal Of Psychiatry 1995, 152: 1812-1814. PMID: 8526253, DOI: 10.1176/ajp.152.12.1812.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderRefractory obsessive-compulsive disorderGlobal improvement itemObsessive-compulsive disorderClozapine monotherapyClinical Global Impression ScaleHamilton Depression Rating ScaleMost adult patientsGlobal Impression ScaleDepression Rating ScaleLack of efficacyYale-Brown Obsessive Compulsive ScaleCGI global improvement itemObsessive Compulsive ScaleAdult patientsImpression ScaleDepressive symptomsImprovement itemsMonotherapyRating ScaleCompulsive ScaleDisordersPatientsTrialsEfficacy