Tryptophan Depletion in Patients With Obsessive-Compulsive Disorder Who Respond to Serotonin Reuptake Inhibitors
Barr LC, Goodman WK, McDougle CJ, Delgado PL, Heninger GR, Charney DS, Price LH. Tryptophan Depletion in Patients With Obsessive-Compulsive Disorder Who Respond to Serotonin Reuptake Inhibitors. JAMA Psychiatry 1994, 51: 309-317. PMID: 8161291, DOI: 10.1001/archpsyc.1994.03950040053007.Peer-Reviewed Original ResearchConceptsShort-term tryptophan depletionSerotonin reuptake inhibitorsTryptophan depletionReuptake inhibitorsObsessive-compulsive disorderFree plasma tryptophan levelsPlacebo-controlled cross-over designLow tryptophan dietPlasma tryptophan levelsAmino acid drinkCross-over designDepression ratingsDepressive symptomsSymptom reductionAcid drinkTryptophan levelsDSM-IIIPatientsNext morningCompulsive symptomsSymptomsDisordersDietInhibitorsDrinks