2010
Probing GABA Receptor Function in Schizophrenia with Iomazenil
Ahn K, Gil R, Seibyl J, Sewell RA, D'Souza DC. Probing GABA Receptor Function in Schizophrenia with Iomazenil. Neuropsychopharmacology 2010, 36: 677-683. PMID: 21068719, PMCID: PMC3055690, DOI: 10.1038/npp.2010.198.Peer-Reviewed Original ResearchConceptsSchizophrenia patientsHealthy controlsGABA deficitHealthy subjectsBrief Psychiatric Rating ScaleGABA-deficit hypothesisPlacebo-controlled studyChronic schizophrenia patientsPathophysiology of schizophreniaPsychiatric Rating ScalePartial inverse agonistDissociative Symptoms ScaleGABA receptor functionPerceptual alterationsPsychotomimetic effectsPsychotic symptomsIomazenilBenzodiazepine receptorsPatientsSymptom ScalePharmacological inductionReceptor functionInverse agonistRating ScaleBrain imaging
2004
White matter hyperintensities in subjects with bipolar disorder
AHN KH, LYOO IK, LEE HK, SONG IC, OH JS, HWANG J, KWON J, KIM MJ, KIM M, RENSHAW PF. White matter hyperintensities in subjects with bipolar disorder. Psychiatry And Clinical Neurosciences 2004, 58: 516-521. PMID: 15482583, DOI: 10.1111/j.1440-1819.2004.01294.x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesBipolar disorderMatter hyperintensitiesComparison subjectsSubcortical white matter hyperintensitiesSeverity of WMHSevere white matter hyperintensitiesDeep white matter hyperintensitiesRating ScaleStructured Clinical InterviewStatistical Manual IVHealthy comparison subjectsInversion recovery imagesHigh prevalenceBipolar patientsBipolar subjectsGreater prevalenceClinical InterviewMagnetic resonance imagesMagnetic resonance scannerPrevalenceRecovery imagesDivergent reportsDisordersBrain magnetic resonance images