2007
Glutamatergic and GABAergic Neurotransmitter Cycling and Energy Metabolism in Rat Cerebral Cortex during Postnatal Development
Chowdhury G, Patel AB, Mason GF, Rothman DL, Behar KL. Glutamatergic and GABAergic Neurotransmitter Cycling and Energy Metabolism in Rat Cerebral Cortex during Postnatal Development. Cerebrovascular And Brain Metabolism Reviews 2007, 27: 1895-1907. PMID: 17440492, DOI: 10.1038/sj.jcbfm.9600490.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAlgorithmsAmino AcidsAnimalsBlood GlucoseBrain ChemistryCerebral CortexCitric Acid CycleData Interpretation, StatisticalEnergy MetabolismGamma-Aminobutyric AcidGlucoseGlutamic AcidKineticsMagnetic Resonance SpectroscopyMaleNeurogliaNeuronsNeurotransmitter AgentsRatsRats, Sprague-DawleyConceptsNeurotransmitter cyclingThree-compartment metabolic modelEnergy metabolismRat cerebral cortexUrethane-anesthetized ratsPostnatal day 10Gamma-aminobutyric acidGABA neuronsTCA cycle fluxCerebral cortexAdult cortexPostnatal developmentDay 10Oxidative energy metabolismCycle fluxIndividual neuronsAcid levelsContribution of glutamatergicGrowth spurtNeuronsTricarboxylic acid cycle fluxAmino acid levelsTotal cyclingTime courseCortex
2001
In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle flux
1997
Homocarnosine and the measurement of neuronal pH in patients with epilepsy
Rothman D, Behar K, Prichard J, Petroff O. Homocarnosine and the measurement of neuronal pH in patients with epilepsy. Magnetic Resonance In Medicine 1997, 38: 924-929. PMID: 9402193, DOI: 10.1002/mrm.1910380611.Peer-Reviewed Original Research
1995
Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain
Petroff O, Rothman D, Behar K, Mattson R. Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain. Epilepsia 1995, 36: 457-464. PMID: 7614922, DOI: 10.1111/j.1528-1157.1995.tb00486.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidGABA levelsMumol/Antiepileptic drugsOccipital GABA levelsEffective antiepileptic drugEffects of vigabatrinStandard medicationStandard doseΓ-aminobutyric acidHealthy subjectsEpileptic patientsVigabatrinPatientsGABA transaminaseHuman cerebrumNoninvasive measurementHuman brainBrainGlutamateInitial observationsMedicationsCerebrumLevelsDose
1994
Measurement of GABA following GABA‐transaminase inhibition by gabaculine: A 1H and 31P NMR spectroscopic study of rat brain in vivo
Behar K, Boehm D. Measurement of GABA following GABA‐transaminase inhibition by gabaculine: A 1H and 31P NMR spectroscopic study of rat brain in vivo. Magnetic Resonance In Medicine 1994, 31: 660-667. PMID: 7914662, DOI: 10.1002/mrm.1910310612.Peer-Reviewed Original ResearchMeSH Keywords4-Aminobutyrate TransaminaseAnimalsAspartic AcidBrainBrain ChemistryCreatineCyclohexanecarboxylic AcidsGamma-Aminobutyric AcidGlutamatesGlutamic AcidHydrogenHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopyMaleNucleotidesPhosphatesPhosphocreatinePhosphorusRatsRats, Sprague-Dawley
1993
Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain
Behar K, Ogino T. Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain. Magnetic Resonance In Medicine 1993, 30: 38-44. PMID: 8371672, DOI: 10.1002/mrm.1910300107.Peer-Reviewed Original Research
1992
NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain
Mason G, Rothman D, Behar K, Shulman R. NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 434-447. PMID: 1349022, DOI: 10.1038/jcbfm.1992.61.Peer-Reviewed Original ResearchNMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain
Mason G, Behar K, Rothman D, Shulman R. NMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 448-455. PMID: 1569138, DOI: 10.1038/jcbfm.1992.62.Peer-Reviewed Original Research
1991
Assignment of resonances in the 1H spectrum of rat brain by two‐dimensional shift correlated and j‐resolved NMR spectroscopy
Behar K, Ogino T. Assignment of resonances in the 1H spectrum of rat brain by two‐dimensional shift correlated and j‐resolved NMR spectroscopy. Magnetic Resonance In Medicine 1991, 17: 285-303. PMID: 1676483, DOI: 10.1002/mrm.1910170202.Peer-Reviewed Original Research
1985
Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies.
Petroff O, Prichard J, Behar K, Rothman D, Alger J, Shulman R. Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies. Neurology 1985, 35: 1681-8. PMID: 2933595, DOI: 10.1212/wnl.35.12.1681.Peer-Reviewed Original Research