Changes in N-acetylaspartate and myo-inositol detected in the cerebral cortex of hamsters with Creutzfeldt-Jakob disease
Behar K, Boucher R, Fritch W, Manuelidis L. Changes in N-acetylaspartate and myo-inositol detected in the cerebral cortex of hamsters with Creutzfeldt-Jakob disease. Magnetic Resonance Imaging 1998, 16: 963-968. PMID: 9814779, DOI: 10.1016/s0730-725x(98)00109-x.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseAge-matched controlsCerebral cortexHuman Creutzfeldt-Jakob diseaseMagnetic resonance spectroscopy studySyrian hamster brainHIV dementiaPathogenetic pathwaysCortical levelN-acetylaspartateTerminal diseaseAlzheimer's diseaseMyo-inositolDiseaseNeurodegenerative diseasesHamster brainMetabolite levelsSignificant decreaseHamstersDementiaCortexSignificant changesLate changesWeight metabolitesDays