1999
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics
Rothman D, Sibson N, Hyder F, Shen J, Behar K, Shulman R. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 1165-1177. PMID: 10466144, PMCID: PMC1692640, DOI: 10.1098/rstb.1999.0472.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGlutamate-glutamine cycleNerve terminalsNeurotransmitter cycleGlucose metabolismBlood oxygenation level-dependent magnetic resonance imagingLevel-dependent magnetic resonance imagingBrain glucose oxidationCortical glucose metabolismMagnetic resonance spectroscopy studyCortex of ratsMagnetic resonance imagingFunctional imaging studiesSpecific neuronal activityOxidative glucose metabolismGlial cellsNeuronal activityResonance imagingImaging studiesHuman cortexBrain functionBrain activityRatsCortexGlucose oxidationGlutamate
1998
Changes in N-acetylaspartate and myo-inositol detected in the cerebral cortex of hamsters with Creutzfeldt-Jakob disease
Behar K, Boucher R, Fritch W, Manuelidis L. Changes in N-acetylaspartate and myo-inositol detected in the cerebral cortex of hamsters with Creutzfeldt-Jakob disease. Magnetic Resonance Imaging 1998, 16: 963-968. PMID: 9814779, DOI: 10.1016/s0730-725x(98)00109-x.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseAge-matched controlsCerebral cortexHuman Creutzfeldt-Jakob diseaseMagnetic resonance spectroscopy studySyrian hamster brainHIV dementiaPathogenetic pathwaysCortical levelN-acetylaspartateTerminal diseaseAlzheimer's diseaseMyo-inositolDiseaseNeurodegenerative diseasesHamster brainMetabolite levelsSignificant decreaseHamstersDementiaCortexSignificant changesLate changesWeight metabolitesDays