Featured Publications
Drinking Goals and Attainment in a Naltrexone Trial of Young Adult Heavy Drinkers
DeMartini KS, Foster DW, Corbin WR, Fucito LM, Romano D, Leeman RF, Kranzler HR, O’Malley S. Drinking Goals and Attainment in a Naltrexone Trial of Young Adult Heavy Drinkers. Journal Of Consulting And Clinical Psychology 2018, 86: 765-774. PMID: 30138015, PMCID: PMC6435339, DOI: 10.1037/ccp0000323.Peer-Reviewed Original ResearchConceptsTreatment outcomesAdult heavy drinkersYoung adult heavy drinkersHeavy drinkersDrinking goalEnd of treatmentPeak drinkingBetter treatment outcomesAlcohol use disorderImpact treatment outcomesTypical drinkingYoung adult drinkersEfficacy trialsUse disordersBrief counselingGoal settingIntervention effectsGoal-setting exercisesAdult drinkersDrinkersOutcomesDrinkingTreatmentImportant targetMidtreatment
2022
Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation
Waddell JT, Corbin WR, MacKinnon DP, Leeman RF, DeMartini KS, Fucito LM, Kranzler HR, O’Malley S. Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation. Alcohol Clinical And Experimental Research 2022, 46: 477-491. PMID: 35076087, PMCID: PMC9679805, DOI: 10.1111/acer.14780.Peer-Reviewed Original ResearchConceptsMedication dosageYoung adultsLight drinkingSubjective responsesSubjective effectsHeavy drinkingPlacebo-controlled studyEffect sizePerson effectsEffective treatmentNaltrexoneDrinking daysNaltrexone efficacySmall effect sizesDrinking levelsCravingDrinkingAdultsLaboratory-based studiesPillsMomentary assessmentEfficacyTreatment conditionsDrinking environmentsDaily diary data
2021
Reward drinking and naltrexone treatment response among young adult heavy drinkers
Roos CR, Bold KW, Witkiewitz K, Leeman RF, DeMartini KS, Fucito LM, Corbin WR, Mann K, Kranzler HR, O'Malley SS. Reward drinking and naltrexone treatment response among young adult heavy drinkers. Addiction 2021, 116: 2360-2371. PMID: 33620746, PMCID: PMC8328878, DOI: 10.1111/add.15453.Peer-Reviewed Original Research
2016
Urgency traits moderate daily relations between affect and drinking to intoxication among young adults
Bold KW, Fucito LM, DeMartini KS, Leeman RF, Kranzler HR, Corbin WR, O’Malley S. Urgency traits moderate daily relations between affect and drinking to intoxication among young adults. Drug And Alcohol Dependence 2016, 170: 59-65. PMID: 27875802, PMCID: PMC5183550, DOI: 10.1016/j.drugalcdep.2016.10.035.Peer-Reviewed Original ResearchConceptsYoung adultsHeavy drinkingEffectiveness of naltrexoneBlood alcohol concentrationHeavy drinking young adultsBrief motivational interventionNaltrexone treatmentClinical trialsHazardous drinkingNaltrexoneSecondary analysisPlaceboTargeted interventionsAge 18Alcohol useIntoxicationLow urgencyAdultsMotivational interventionDrinkingTrait urgencyOddsInterventionCurrent studyRiskDaily Relations Among Affect, Urge, Targeted Naltrexone, and Alcohol Use in Young Adults
Bold KW, Fucito LM, Corbin WR, DeMartini KS, Leeman RF, Kranzler HR, O’Malley S. Daily Relations Among Affect, Urge, Targeted Naltrexone, and Alcohol Use in Young Adults. Experimental And Clinical Psychopharmacology 2016, 24: 367-375. PMID: 27690505, PMCID: PMC5111359, DOI: 10.1037/pha0000090.Peer-Reviewed Original ResearchConceptsYoung adultsDouble-blind clinical trialHeavy drinkingSerious public health problemDose of medicationPublic health problemAlcohol-related interventionsTargeted naltrexoneNaltrexone groupOpioid antagonistRisk factorsClinical trialsFamily historyNaltrexone effectsGreater oddsAlcohol consumptionHealth problemsAlcohol dependenceSecondary analysisPlaceboNaltrexoneNaltrexone's abilityAdultsMedicationsDrinkingLongitudinal Findings From a Randomized Clinical Trial of Naltrexone for Young Adult Heavy Drinkers
DeMartini KS, Gueorguieva R, Leeman RF, Corbin WR, Fucito LM, Kranzler HR, O’Malley S. Longitudinal Findings From a Randomized Clinical Trial of Naltrexone for Young Adult Heavy Drinkers. Journal Of Consulting And Clinical Psychology 2016, 84: 185-190. PMID: 26654213, PMCID: PMC4941818, DOI: 10.1037/ccp0000053.Peer-Reviewed Original ResearchConceptsPercent days abstinentFirst placebo-controlled trialPercent days heavy drinkingHeavy drinkingPlacebo-controlled trialLong-term outcomesHeavy drinking daysYoung adults ages 18Adults ages 18Naltrexone conditionActive medicationPlacebo groupPharmacotherapy trialsAdult heavy drinkersYoung adult heavy drinkersNonsignificant decreaseSignificant benefitsYear posttreatmentDays abstinentDrinking daysMost outcomesSingle interventionHeavy drinkersTreatment improvementAge 18
2015
Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety.
O'Malley SS, Corbin WR, Leeman RF, DeMartini KS, Fucito LM, Ikomi J, Romano DM, Wu R, Toll BA, Sher KJ, Gueorguieva R, Kranzler HR. Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety. The Journal Of Clinical Psychiatry 2015, 76: e207-13. PMID: 25742208, PMCID: PMC4442987, DOI: 10.4088/jcp.13m08934.Peer-Reviewed Original ResearchConceptsHeavy drinking daysBlood alcohol concentrationPercent days abstinentDrinking daysNumber of drinksYoung adultsDays abstinentPercent heavy drinking daysOutpatient research centerSafety of naltrexonePlacebo-controlled studySerious adverse eventsRisk-benefit ratioPercentage of daysAdverse eventsSecondary outcomesPrimary outcomeFrequency of drinkingOpioid antagonistAdult heavy drinkersAlcohol drinkingClinical trialsEvaluable samplesYoung adult heavy drinkersTreatment period
2014
A New Look at Risk-Taking: Using a Translational Approach to Examine Risk-Taking Behavior on the Balloon Analogue Risk Task
DeMartini KS, Leeman RF, Corbin WR, Toll BA, Fucito LM, Lejuez CW, O’Malley S. A New Look at Risk-Taking: Using a Translational Approach to Examine Risk-Taking Behavior on the Balloon Analogue Risk Task. Experimental And Clinical Psychopharmacology 2014, 22: 444-452. PMID: 25069012, PMCID: PMC4392709, DOI: 10.1037/a0037421.Peer-Reviewed Original Research