2016
Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence
Hillmer AT, Kloczynski T, Sandiego CM, Pittman B, Anderson JM, Labaree D, Gao H, Huang Y, Deluliis G, O'Malley SS, Carson RE, Cosgrove KP. Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence. Alcohol Clinical And Experimental Research 2016, 40: 698-705. PMID: 26971694, PMCID: PMC4983773, DOI: 10.1111/acer.12997.Peer-Reviewed Original ResearchConceptsGABAA receptor availabilityPositron emission tomographyAlcohol abstinenceAlcohol withdrawalNicotine abstinenceReceptor availabilityTobacco smokingNonhuman primatesContinued nicotine useNicotine replacement therapyWeeks of abstinenceSelf-administer alcoholAdolescent male rhesus macaquesDays of abstinenceSignificant group effectMale rhesus macaquesNicotine cessationNicotine exposureReplacement therapyNicotine useAlcohol dependenceEmission tomographyDrug abstinenceSmokingNicotine
1999
Naltrexone pretreatment decreases the reinforcing effectiveness of ethanol and saccharin but not PCP or food under concurrent progressive-ratio schedules in rhesus monkeys
Rodefer J, Campbell U, Cosgrove K, Carroll M. Naltrexone pretreatment decreases the reinforcing effectiveness of ethanol and saccharin but not PCP or food under concurrent progressive-ratio schedules in rhesus monkeys. Psychopharmacology 1999, 141: 436-446. PMID: 10090652, DOI: 10.1007/s002130050854.Peer-Reviewed Original ResearchConceptsConcurrent progressive-ratio schedulesProgressive ratio scheduleNaltrexone dosesNaltrexone pretreatmentRhesus monkeysDoses of naltrexoneFood-maintained respondingEffectiveness of drugsSaccharin-maintained respondingNaltrexone antagonismSignificant linear trendEthanol consumptionBaseline levelsNaltrexoneBreak point valuesDosesNon-drug reinforcersEffectiveness of ethanolSelective changesEthanol-maintained respondingDoseMonkeysSaccharin