2020
Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study)
Oldham MA, Lin I, Hawkins KA, Li F, Yuh DD, Lee HB. Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study). International Journal Of Geriatric Psychiatry 2020, 36: 452-460. PMID: 33022808, PMCID: PMC9326959, DOI: 10.1002/gps.5443.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac Surgical ProceduresCognitionCoronary Artery BypassDepressionFemaleHumansNeuropsychological TestsProspective StudiesConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryBypass graft surgeryCABG surgeryGraft surgeryCDR-SBProspective observational cohort studyOlder ageOne monthHamilton Depression Rating ScaleClinical Dementia Rating SumHeart Surgery studyObservational cohort studyDepression Rating ScaleSemi-structured clinical interviewTotal study sampleHopkins Verbal Learning TestPostoperative deliriumPreoperative depressionWord Fluency TestCohort studyVerbal Learning TestNeuropsychiatric outcomesTertiary careFunctional outcome
2018
The effect of age and smoking on the hippocampus and memory in late middle age
Hawkins KA, Emadi N, Pearlson GD, Taylor B, Khadka S, King D, Blank K. The effect of age and smoking on the hippocampus and memory in late middle age. Hippocampus 2018, 28: 846-849. PMID: 30070068, DOI: 10.1002/hipo.23014.Peer-Reviewed Original ResearchConceptsSmoking historyHippocampal volumeHeavy smoking historyVascular risk factorsMiddle-aged subjectsMRI brain scanningAPOE e4 genotypeEffect of ageHeavy smokingHippocampal atrophyAlcohol historyRisk factorsE4 genotypeBrain scanningAPOE e4Neuropsychological assessment batteryHippocampus atrophyFemale subjectsGlobal cognitionMemory disordersData extractionMemory declineAssessment BatteryAgeSmokingCognition among individuals along a spectrum of increased risk for Parkinson’s disease
Chahine LM, Urbe L, Caspell-Garcia C, Aarsland D, Alcalay R, Barone P, Burn D, Espay AJ, Hamilton JL, Hawkins KA, Lasch S, Leverenz JB, Litvan I, Richard I, Siderowf A, Coffey CS, Simuni T, Weintraub D, Initiative T. Cognition among individuals along a spectrum of increased risk for Parkinson’s disease. PLOS ONE 2018, 13: e0201964. PMID: 30125297, PMCID: PMC6101368, DOI: 10.1371/journal.pone.0201964.Peer-Reviewed Original ResearchConceptsParkinson's diseaseIdiopathic REM sleep behavior disorderParkinson's Progression Markers Initiative (PPMI) studyDe novo Parkinson's diseaseREM sleep behavior disorderDopamine transporterNon-motor symptomsNovo Parkinson's diseaseSleep behavior disorderNon-motor featuresSymbol Digit Modalities TestBaseline neuropsychological performanceMontreal Cognitive AssessmentFuture neurodegenerationLewy bodiesInclusion criteriaSpectrum of riskMutation carriersInitiative studyCohortBehavior disorderCognitive functionCognitive test scoresModalities TestNeuropsychological performanceGuanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial
Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.Peer-Reviewed Original ResearchConceptsDose of guanfacineQuality of lifeZ-scoreCognitive functionPrefrontal cognitive dysfunctionCommon adverse eventsPrimary outcome measureRandomized clinical trialsGlobal functionOlder participantsHealthy older participantsPrefrontal cognitive functionDry mouthAdverse eventsAgonist guanfacineClinical trialsGuanfacine treatmentCognitive dysfunctionMean changeOutcome measuresPlaceboGuanfacineOlder individualsWeeksDose
2015
Cognitive and functional status predictors of delirium and delirium severity after coronary artery bypass graft surgery: an interim analysis of the Neuropsychiatric Outcomes After Heart Surgery study
Oldham MA, Hawkins KA, Yuh DD, Dewar ML, Darr UM, Lysyy T, Lee HB. Cognitive and functional status predictors of delirium and delirium severity after coronary artery bypass graft surgery: an interim analysis of the Neuropsychiatric Outcomes After Heart Surgery study. International Psychogeriatrics 2015, 27: 1929-1938. PMID: 26423721, PMCID: PMC9310349, DOI: 10.1017/s1041610215001477.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentHeart Surgery studyConfusion Assessment MethodPost-operative deliriumDelirium severityLawton IADL scoresIADL scoresNeuropsychiatric outcomesDelirium IndexSurgery StudyCoronary artery bypass graft surgeryArtery bypass graft surgeryPost-operative day 2Clinical Dementia Rating ScaleMCI-NCElective CABG surgeryBypass graft surgeryObservational cohort studyDementia Rating ScaleCABG surgeryGraft surgeryCohort studyFunctional statusFunctional impairmentCDR sumCognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings
Chahine M, Weintraub D, Hawkins KA, Siderowf A, Eberly S, Oakes D, Seibyl J, Stern MB, Marek K, Jennings D, Investigators T. Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings. Movement Disorders 2015, 31: 86-94. PMID: 26293177, PMCID: PMC4827252, DOI: 10.1002/mds.26373.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnxietyAttentionCocaineCognition DisordersCohort StudiesExecutive FunctionFemaleHumansLanguageMaleMemoryMiddle AgedNeurogenic BowelNeuropsychological TestsOlfaction DisordersParkinson DiseaseProtein BindingRadiopharmaceuticalsSelf ReportSeverity of Illness IndexStatistics, NonparametricSurveys and QuestionnairesTomography, Emission-Computed, Single-PhotonVisual PerceptionConceptsExecutive function/Global cognitionRelative impairmentSpecific cognitive domainsSpeed/attentionGlobal cognitive abilityNeuropsychological test batteryLower global cognitionFunction/Cognitive abilitiesCognitive domainsCognitive profileVisuospatial abilitiesLanguage domainsCognitive testingTest batteryCognitionNormative scoresMemoryLower mean scoresHealthy adultsNon-motor featuresIndividualsStudy findingsNon-motor symptomsRBANS Norms based on the Relationship of Age, Gender, Education, and WRAT-3 Reading to Performance within an Older African American Sample
Andreotti C, Hawkins KA. RBANS Norms based on the Relationship of Age, Gender, Education, and WRAT-3 Reading to Performance within an Older African American Sample. The Clinical Neuropsychologist 2015, 29: 442-465. PMID: 26035646, DOI: 10.1080/13854046.2015.1039589.Peer-Reviewed Original Research
2012
The course of cognitive functioning over six months in individuals at clinical high risk for psychosis
Barbato M, Colijn MA, Keefe RS, Perkins DO, Woods SW, Hawkins KA, Christensen BK, Addington J. The course of cognitive functioning over six months in individuals at clinical high risk for psychosis. Psychiatry Research 2012, 206: 195-199. PMID: 23159196, PMCID: PMC3600156, DOI: 10.1016/j.psychres.2012.10.013.Peer-Reviewed Original ResearchConceptsClinical high riskCHR individualsComprehensive cognitive test batteryCognitive test batteryCognitive impairmentFuture longitudinal researchCognitive functioningCognitive performanceCognitive testsTest batteryLongitudinal researchCognitionPoor performanceLongitudinal changesPsychosisIndividualsParticipantsImpairmentBaseline participantsFunctioningPerformanceBatteriesResearchProdromeDefault mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regionsTraditional neuropsychological correlates and reliability of the Automated Neuropsychological Assessment Metrics-4 battery for Parkinson’s disease
Hawkins KA, Jennings D, Vincent AS, Gilliland K, West A, Marek K. Traditional neuropsychological correlates and reliability of the Automated Neuropsychological Assessment Metrics-4 battery for Parkinson’s disease. Parkinsonism & Related Disorders 2012, 18: 864-870. PMID: 22609082, DOI: 10.1016/j.parkreldis.2012.04.021.Peer-Reviewed Original Research
2010
Neuropsychology of the Prodrome to Psychosis in the NAPLS Consortium: Relationship to Family History and Conversion to Psychosis
Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF, Woods SW, Bearden CE, Christensen BK, Hawkins K, Heaton R, Keefe RS, Heinssen R, Cornblatt BA. Neuropsychology of the Prodrome to Psychosis in the NAPLS Consortium: Relationship to Family History and Conversion to Psychosis. JAMA Psychiatry 2010, 67: 578-588. PMID: 20530007, PMCID: PMC3332118, DOI: 10.1001/archgenpsychiatry.2010.66.Peer-Reviewed Original ResearchConceptsFamily historyCHR individualsNeuropsychological functioningCHR syndromeNorth American Prodrome Longitudinal StudyClinical high-risk individualsHigh-risk groupFirst-episode schizophreniaBaseline neuropsychological evaluationHigh-risk individualsSecond-degree relativesHigh-risk statusLongitudinal studyGlobal neuropsychological functioningWorse verbal memoryPrediction of psychosisCHR assessmentSyndrome criteriaProspective evaluationClinical criteriaModerate severityNeurocognitive composite scorePsychosis onsetNormal controlsSubsequent psychosis
2009
The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis
Wisdom NM, Callahan JL, Hawkins KA. The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis. Neurobiology Of Aging 2009, 32: 63-74. PMID: 19285755, DOI: 10.1016/j.neurobiolaging.2009.02.003.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsApolipoproteins ECognitionDatabases, FactualHumansNeuropsychological TestsPublication BiasZygoteConceptsGlobal cognitive abilityEpisodic memoryCognitive abilitiesApoE allele 4Previous meta-analytic findingsMeta-analytic findingsPossible moderating variablesHealthy adultsPerceptual speedExecutive functioningCognitive functioningNeurocognitive functionNeurocognitive examinationModerating variableCurrent studyMemoryFunctioningSmall effectAdultsMeasuresPrevious examinationsAbilityParticipantsCurrent literatureAllele 4
2008
Neuropsychological course in the prodrome and first episode of psychosis: Findings from the PRIME North America Double Blind Treatment Study
Hawkins KA, Keefe RS, Christensen BK, Addington J, Woods SW, Callahan J, Zipursky RB, Perkins DO, Tohen M, Breier A, McGlashan TH. Neuropsychological course in the prodrome and first episode of psychosis: Findings from the PRIME North America Double Blind Treatment Study. Schizophrenia Research 2008, 105: 1-9. PMID: 18774696, DOI: 10.1016/j.schres.2008.07.008.Peer-Reviewed Original ResearchConceptsNeuropsychological courseDouble-blind treatment studyNeuropsychological StatusPlacebo-assigned subjectsPutative prodromal stateDouble-blind trialFrank psychotic episodeEarly convertersOlanzapine treatmentNeuropsychological deficienciesFrank psychosisMedication studiesFirst episodePsychotic episodeProdromal stateHigh riskBlind trialNeuropsychological declineTreatment studiesPsychotic conditionsPsychosisLate convertersOlanzapineProdromeInitial assessmentSelf-Reported Distress After Cognitive Testing in Patients With Alzheimer's Disease
Lai JM, Hawkins KA, Gross CP, Karlawish JH. Self-Reported Distress After Cognitive Testing in Patients With Alzheimer's Disease. The Journals Of Gerontology Series A 2008, 63: 855-859. PMID: 18772474, PMCID: PMC2733161, DOI: 10.1093/gerona/63.8.855.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseFemaleHumansLogistic ModelsMaleNeuropsychological TestsPrevalenceRisk FactorsStress, PsychologicalConceptsSelf-reported distressCognitive testingDepressive symptomsDisease experienceSpecific patient factorsModerate AD patientsMultivariate logistic regressionCognitive performanceMore distressDemographic factorsTest performanceAlzheimer's disease (AD) experienceIntact patientsMultivariable analysisPatient factorsPatient awarenessAD patientsLevel of distressModerate ADPredictors of distressDementia severityPatientsAlzheimer's diseaseBivariate analysisLogistic regression
2007
Aripiprazole in the treatment of the psychosis prodrome
Woods SW, Tully EM, Walsh BC, Hawkins KA, Callahan JL, Cohen SJ, Mathalon DH, Miller TJ, McGlashan TH. Aripiprazole in the treatment of the psychosis prodrome. The British Journal Of Psychiatry. Supplement 2007, 191: s96-s101. PMID: 18055946, DOI: 10.1192/bjp.191.51.s96.Peer-Reviewed Original ResearchConceptsPsychosis prodromeMixed-effects repeated-measures analysisShort-term efficacySymptom total scoreSingle-site trialRepeated-measures analysisAripiprazole treatmentAdverse eventsFinal visitSafety profilePromising efficacyProdromal phasePsychotic disordersScale scoreBaseline levelsWeight gainFirst weekProdromeTotal scoreAripiprazoleTreatmentNeuropsychological measuresPreliminary evidenceWeeksEfficacyExtracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population
Hoffman RE, Woods SW, Hawkins KA, Pittman B, Tohen M, Preda A, Breier A, Glist J, Addington J, Perkins DO, McGlashan TH. Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. The British Journal Of Psychiatry 2007, 191: 355-356. PMID: 17906248, DOI: 10.1192/bjp.bp.106.031195.Peer-Reviewed Original ResearchMeSH KeywordsDelusionsDisease ProgressionHumansNeuropsychological TestsNoisePredictive Value of TestsRisk FactorsSchizophreniaSchizophrenic PsychologySpeech PerceptionConceptsSchizophrenia spectrum disordersTime-dependent Cox regression analysisCox regression analysisMedication-free intervalOlanzapine treatmentPlacebo groupPharmacological treatmentProdromal symptomsRisk factorsProdromal populationSpeech illusionsDisordersRegression analysisYear 2TreatmentSignificant interactionYear 1Symptoms
2004
Replacement of the Faces Subtest by Visual Reproductions Within Wechsler Memory Scale – Third Edition (WMS-III) Visual Memory Indexes: Implications for Discrepancy Analysis
Hawkins KA, Tulsky DS. Replacement of the Faces Subtest by Visual Reproductions Within Wechsler Memory Scale – Third Edition (WMS-III) Visual Memory Indexes: Implications for Discrepancy Analysis. Journal Of Clinical And Experimental Neuropsychology 2004, 26: 498-510. PMID: 15512937, DOI: 10.1080/13803390490496632.Peer-Reviewed Original ResearchNeuropsychological status of subjects at high risk for a first episode of psychosis
Hawkins KA, Addington J, Keefe RS, Christensen B, Perkins DO, Zipurksy R, Woods SW, Miller TJ, Marquez E, Breier A, McGlashan TH. Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophrenia Research 2004, 67: 115-122. PMID: 14984870, DOI: 10.1016/j.schres.2003.08.007.Peer-Reviewed Original ResearchConceptsFirst episodeFirst psychotic episodeLevel of impairmentSchizophrenia prodromePsychotic episodeHigh riskMulti-site studyProdromal interventionPopulation normsNeuropsychological examNeuropsychological StatusNeuropsychological functioningNormal intelligenceEpisodesSchizophrenia samplePsychosisSubjectsRiskStatusProdromeSchizophreniaImpairmentSeverityAlternative Forms of the Rey Auditory Verbal Learning Test: A Review
Hawkins KA, Dean D, Pearlson GD. Alternative Forms of the Rey Auditory Verbal Learning Test: A Review. Behavioural Neurology 2004, 15: 99-107. PMID: 15706053, PMCID: PMC5488610, DOI: 10.1155/2004/940191.Peer-Reviewed Original Research
2003
Transcranial Magnetic Stimulation of Left Temporoparietal Cortex and Medication-Resistant Auditory Hallucinations
Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, Krystal JH. Transcranial Magnetic Stimulation of Left Temporoparietal Cortex and Medication-Resistant Auditory Hallucinations. JAMA Psychiatry 2003, 60: 49-56. PMID: 12511172, DOI: 10.1001/archpsyc.60.1.49.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationMedication-resistant auditory hallucinationsTranscranial magnetic stimulationLeft temporoparietal cortexAuditory hallucinationsSham stimulationMagnetic stimulationTemporoparietal cortexOpen-label trialMotor thresholdAntipsychotic medicationSustained reductionBrain areasSchizoaffective disorderCortical activationPossible treatmentNeuropsychological impairmentNeuropsychological assessmentPatientsAdditional studiesCortexStimulationTrialsHallucinationsTreatment effects