2020
Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study)
Oldham MA, Lin I, Hawkins KA, Li F, Yuh DD, Lee HB. Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study). International Journal Of Geriatric Psychiatry 2020, 36: 452-460. PMID: 33022808, PMCID: PMC9326959, DOI: 10.1002/gps.5443.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryBypass graft surgeryCABG surgeryGraft surgeryCDR-SBProspective observational cohort studyOlder ageOne monthHamilton Depression Rating ScaleClinical Dementia Rating SumHeart Surgery studyObservational cohort studyDepression Rating ScaleSemi-structured clinical interviewTotal study sampleHopkins Verbal Learning TestPostoperative deliriumPreoperative depressionWord Fluency TestCohort studyVerbal Learning TestNeuropsychiatric outcomesTertiary careFunctional outcomeNeuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease
Weintraub D, Caspell‐Garcia C, Simuni T, Cho HR, Coffey CS, Aarsland D, Alcalay RN, Barrett MJ, Chahine LM, Eberling J, Espay AJ, Hamilton J, Hawkins KA, Leverenz J, Litvan I, Richard I, Rosenthal LS, Siderowf A, York M, Initiative P. Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease. Annals Of Clinical And Translational Neurology 2020, 7: 449-461. PMID: 32285645, PMCID: PMC7187707, DOI: 10.1002/acn3.51022.Peer-Reviewed Original ResearchConceptsParkinson's disease participantsNeuropsychiatric symptomsParkinson's diseaseHealthy controlsCognitive impairmentMedication useYear 5Anticholinergic medication useCross-sectional prevalenceParkinson's disease patientsHypnotic useDisease patientsNeuropsychiatric featuresDisease onsetAnnual visitsSymptomsDisorder subtypesAbsolute prevalenceDiseaseTime pointsPrevalenceBaselineImpairmentParticipantsOnset
2018
Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study
Oldham MA, Hawkins KA, Lin IH, Deng Y, Hao Q, Scoutt LM, Yuh DD, Lee HB. Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study. American Journal Of Geriatric Psychiatry 2018, 27: 476-486. PMID: 30709616, PMCID: PMC6443412, DOI: 10.1016/j.jagp.2018.12.025.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMild cognitive impairmentCerebrovascular diseaseCognitive impairmentRisk factorsCoronary artery bypass graft surgeryStenosis severityProspective observational cohort studyArtery bypass graft surgeryBilateral middle cerebral arteriesTertiary care academic hospitalHeart Surgery studyPreoperative cognitive assessmentUndergoing CABG surgeryBypass graft surgeryConfusion Assessment MethodRisk of deliriumDelirium risk factorsObservational cohort studyPostoperative day 2Clinical Dementia RatingDepression InterviewPreoperative depressionStructured HamiltonStudy psychiatristCognition among individuals along a spectrum of increased risk for Parkinson’s disease
Chahine LM, Urbe L, Caspell-Garcia C, Aarsland D, Alcalay R, Barone P, Burn D, Espay AJ, Hamilton JL, Hawkins KA, Lasch S, Leverenz JB, Litvan I, Richard I, Siderowf A, Coffey CS, Simuni T, Weintraub D, Initiative T. Cognition among individuals along a spectrum of increased risk for Parkinson’s disease. PLOS ONE 2018, 13: e0201964. PMID: 30125297, PMCID: PMC6101368, DOI: 10.1371/journal.pone.0201964.Peer-Reviewed Original ResearchConceptsParkinson's diseaseIdiopathic REM sleep behavior disorderParkinson's Progression Markers Initiative (PPMI) studyDe novo Parkinson's diseaseREM sleep behavior disorderDopamine transporterNon-motor symptomsNovo Parkinson's diseaseSleep behavior disorderNon-motor featuresSymbol Digit Modalities TestBaseline neuropsychological performanceMontreal Cognitive AssessmentFuture neurodegenerationLewy bodiesInclusion criteriaSpectrum of riskMutation carriersInitiative studyCohortBehavior disorderCognitive functionCognitive test scoresModalities TestNeuropsychological performanceGuanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial
Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.Peer-Reviewed Original ResearchConceptsDose of guanfacineQuality of lifeZ-scoreCognitive functionPrefrontal cognitive dysfunctionCommon adverse eventsPrimary outcome measureRandomized clinical trialsGlobal functionOlder participantsHealthy older participantsPrefrontal cognitive functionDry mouthAdverse eventsAgonist guanfacineClinical trialsGuanfacine treatmentCognitive dysfunctionMean changeOutcome measuresPlaceboGuanfacineOlder individualsWeeksDose
2017
Cognition and the course of prodromal Parkinson's disease
Weintraub D, Chahine LM, Hawkins KA, Siderowf A, Eberly S, Oakes D, Seibyl J, Stern MB, Marek K, Jennings D, Investigators T. Cognition and the course of prodromal Parkinson's disease. Movement Disorders 2017, 32: 1640-1645. PMID: 29063713, PMCID: PMC5722226, DOI: 10.1002/mds.27189.Peer-Reviewed Original ResearchConceptsSpeed/attentionCognitive declineProdromal participantsBaseline neuropsychological test performanceExecutive function/Role of cognitionNeuropsychological test performanceFuture cognitive declineBaseline cognitive scoresCognitive domainsGlobal cognitionBaseline cognitionCognitive scoresCognitionTest performanceFuture declinePD-convertersDopamine systemHyposmic individualsProdromal PDLongitudinal changesFunction/ParticipantsDopamine transporter bindingIndividualsMultiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease
Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D, Initiative T. Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease. PLOS ONE 2017, 12: e0175674. PMID: 28520803, PMCID: PMC5435130, DOI: 10.1371/journal.pone.0175674.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCognitive DysfunctionDiffusion Tensor ImagingDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseasePolymorphism, Single NucleotideTau ProteinsTomography, Emission-Computed, Single-PhotonConceptsParkinson's diseaseCognitive impairmentDe novo Parkinson's diseaseDopamine transporter single-photon emissionLongitudinal mixed-effects modelsNovo Parkinson's diseaseYears of diseaseIdiopathic Parkinson's diseaseMovement Disorders CenterSingle nucleotide polymorphismsStructural magnetic resonance imagingClinical trial designLongitudinal structural MRIMagnetic resonance imagingSingle photon emissionDevelopment of treatmentsDiffusion tensor imagingBiomarker predictorsPlaque pathologyAmyloid pathologyDopamine deficiencyDopaminergic deficitUnivariate analysisBiomarker changesDisorders Center
2015
Cognitive and functional status predictors of delirium and delirium severity after coronary artery bypass graft surgery: an interim analysis of the Neuropsychiatric Outcomes After Heart Surgery study
Oldham MA, Hawkins KA, Yuh DD, Dewar ML, Darr UM, Lysyy T, Lee HB. Cognitive and functional status predictors of delirium and delirium severity after coronary artery bypass graft surgery: an interim analysis of the Neuropsychiatric Outcomes After Heart Surgery study. International Psychogeriatrics 2015, 27: 1929-1938. PMID: 26423721, PMCID: PMC9310349, DOI: 10.1017/s1041610215001477.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentHeart Surgery studyConfusion Assessment MethodPost-operative deliriumDelirium severityLawton IADL scoresIADL scoresNeuropsychiatric outcomesDelirium IndexSurgery StudyCoronary artery bypass graft surgeryArtery bypass graft surgeryPost-operative day 2Clinical Dementia Rating ScaleMCI-NCElective CABG surgeryBypass graft surgeryObservational cohort studyDementia Rating ScaleCABG surgeryGraft surgeryCohort studyFunctional statusFunctional impairmentCDR sumCognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings
Chahine M, Weintraub D, Hawkins KA, Siderowf A, Eberly S, Oakes D, Seibyl J, Stern MB, Marek K, Jennings D, Investigators T. Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings. Movement Disorders 2015, 31: 86-94. PMID: 26293177, PMCID: PMC4827252, DOI: 10.1002/mds.26373.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnxietyAttentionCocaineCognition DisordersCohort StudiesExecutive FunctionFemaleHumansLanguageMaleMemoryMiddle AgedNeurogenic BowelNeuropsychological TestsOlfaction DisordersParkinson DiseaseProtein BindingRadiopharmaceuticalsSelf ReportSeverity of Illness IndexStatistics, NonparametricSurveys and QuestionnairesTomography, Emission-Computed, Single-PhotonVisual PerceptionConceptsExecutive function/Global cognitionRelative impairmentSpecific cognitive domainsSpeed/attentionGlobal cognitive abilityNeuropsychological test batteryLower global cognitionFunction/Cognitive abilitiesCognitive domainsCognitive profileVisuospatial abilitiesLanguage domainsCognitive testingTest batteryCognitionNormative scoresMemoryLower mean scoresHealthy adultsNon-motor featuresIndividualsStudy findingsNon-motor symptomsRBANS Norms based on the Relationship of Age, Gender, Education, and WRAT-3 Reading to Performance within an Older African American Sample
Andreotti C, Hawkins KA. RBANS Norms based on the Relationship of Age, Gender, Education, and WRAT-3 Reading to Performance within an Older African American Sample. The Clinical Neuropsychologist 2015, 29: 442-465. PMID: 26035646, DOI: 10.1080/13854046.2015.1039589.Peer-Reviewed Original ResearchCognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease
Weintraub D, Simuni T, Caspell‐Garcia C, Coffey C, Lasch S, Siderowf A, Aarsland D, Barone P, Burn D, Chahine M, Eberling J, Espay AJ, Foster ED, Leverenz JB, Litvan I, Richard I, Troyer MD, Hawkins KA, Initiative T. Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease. Movement Disorders 2015, 30: 919-927. PMID: 25737166, PMCID: PMC4855523, DOI: 10.1002/mds.26170.Peer-Reviewed Original ResearchConceptsParkinson's Progression Markers InitiativeNeuropsychiatric symptomsPD patientsHealthy controlsProgression Markers InitiativeParkinson's diseaseCognitive impairmentUntreated PD patientsDopamine replacement therapySignificant depressive symptomsGroup differencesSymptoms of depressionQuality of lifeMild cognitive impairmentUntreated patientsDisease courseReplacement therapyICD symptomsControl disordersDepressive symptomsGeneral populationPatientsMeeting criteriaMulti-site studyBiological predictors
2012
Traditional neuropsychological correlates and reliability of the Automated Neuropsychological Assessment Metrics-4 battery for Parkinson’s disease
Hawkins KA, Jennings D, Vincent AS, Gilliland K, West A, Marek K. Traditional neuropsychological correlates and reliability of the Automated Neuropsychological Assessment Metrics-4 battery for Parkinson’s disease. Parkinsonism & Related Disorders 2012, 18: 864-870. PMID: 22609082, DOI: 10.1016/j.parkreldis.2012.04.021.Peer-Reviewed Original ResearchImpaired olfaction and other prodromal features in the Parkinson At‐Risk Syndrome study
Siderowf A, Jennings D, Eberly S, Oakes D, Hawkins KA, Ascherio A, Stern MB, Marek K, Investigators T. Impaired olfaction and other prodromal features in the Parkinson At‐Risk Syndrome study. Movement Disorders 2012, 27: 406-412. PMID: 22237833, PMCID: PMC6342466, DOI: 10.1002/mds.24892.Peer-Reviewed Original ResearchConceptsNonmotor featuresProdromal featuresOlfactory testingRapid eye movement sleep behaviour disorder symptomsSyndrome StudyPennsylvania Smell Identification TestDopamine transporter imagingPercent of subjectsSmell Identification TestRisk of PDFuture neurodegenerationHyposmic subjectsOlfactory dysfunctionImpaired olfactionTransporter imagingMotor functionMotor featuresSmell testNeurological diagnosisUndiagnosed individualsHyposmiaScreening testSpecific markersDisorder symptomsFurther assessment
2011
Age and Gender but Not Common Chronic Illnesses Predict Odor Identification in Older African Americans
Hawkins KA, Pearlson GD. Age and Gender but Not Common Chronic Illnesses Predict Odor Identification in Older African Americans. American Journal Of Geriatric Psychiatry 2011, 19: 777-782. PMID: 21873833, DOI: 10.1097/jgp.0b013e3181f7d8e1.Peer-Reviewed Original ResearchConceptsBrief Smell Identification TestOlder African AmericansChronic illnessBSIT scoresHealthy older African AmericansCommon chronic illnessCommon chronic conditionsLoss of smellSmell Identification TestAfrican AmericansSpecific neurodegenerative diseasesThyroid disordersChronic conditionsLimited normative dataClinical utilityOlder subjectsAge 55Odor identificationNeurodegenerative diseasesGeneral communityEarly detectionMinority cohortGlobal cognitionDemographic predictorsIdentification TestMini-Mental State Exam Performance of Older African Americans: Effect of Age, Gender, Education, Hypertension, Diabetes, and the Inclusion of Serial 7s Subtraction Versus “World” Backward on Score
Hawkins KA, Cromer JR, Piotrowski AS, Pearlson GD. Mini-Mental State Exam Performance of Older African Americans: Effect of Age, Gender, Education, Hypertension, Diabetes, and the Inclusion of Serial 7s Subtraction Versus “World” Backward on Score. Archives Of Clinical Neuropsychology 2011, 26: 645-652. PMID: 21813555, DOI: 10.1093/arclin/acr054.Peer-Reviewed Original Research
2010
Incidence of tardive dyskinesia with atypical versus conventional antipsychotic medications: a prospective cohort study.
Woods SW, Morgenstern H, Saksa JR, Walsh BC, Sullivan MC, Money R, Hawkins KA, Gueorguieva RV, Glazer WM. Incidence of tardive dyskinesia with atypical versus conventional antipsychotic medications: a prospective cohort study. The Journal Of Clinical Psychiatry 2010, 71: 463-74. PMID: 20156410, PMCID: PMC3109728, DOI: 10.4088/jcp.07m03890yel.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmbulatory CareAntipsychotic AgentsCohort StudiesCommunity Mental Health CentersConnecticutDiagnostic and Statistical Manual of Mental DisordersDyskinesia, Drug-InducedFemaleHumansIncidenceLongitudinal StudiesMaleMental DisordersMiddle AgedPrevalenceProspective StudiesPsychiatric Status Rating ScalesRisk FactorsSeverity of Illness IndexConceptsProspective cohort studyConventional antipsychoticsTardive dyskinesiaAtypical antipsychoticsCohort studyPrevious prospective cohort studyCommunity mental health centerConventional antipsychotic medicationsMental health centersAntipsychotic medicationHealth centersBaseline evaluationAntipsychoticsNew diagnosisDyskinesiaClinical practicePsychiatric outpatientsRecent exposureIncidencePrevious visitPrevious studiesPrevalenceSubjectsCurrent studyMost previous studies
2008
Self-Reported Distress After Cognitive Testing in Patients With Alzheimer's Disease
Lai JM, Hawkins KA, Gross CP, Karlawish JH. Self-Reported Distress After Cognitive Testing in Patients With Alzheimer's Disease. The Journals Of Gerontology Series A 2008, 63: 855-859. PMID: 18772474, PMCID: PMC2733161, DOI: 10.1093/gerona/63.8.855.Peer-Reviewed Original ResearchConceptsSelf-reported distressCognitive testingDepressive symptomsDisease experienceSpecific patient factorsModerate AD patientsMultivariate logistic regressionCognitive performanceMore distressDemographic factorsTest performanceAlzheimer's disease (AD) experienceIntact patientsMultivariable analysisPatient factorsPatient awarenessAD patientsLevel of distressModerate ADPredictors of distressDementia severityPatientsAlzheimer's diseaseBivariate analysisLogistic regressionEveryday Decision-Making Ability in Older Persons With Cognitive Impairment
Lai JM, Gill TM, Cooney LM, Bradley EH, Hawkins KA, Karlawish JH. Everyday Decision-Making Ability in Older Persons With Cognitive Impairment. American Journal Of Geriatric Psychiatry 2008, 16: 693-696. PMID: 18669948, PMCID: PMC2730037, DOI: 10.1097/jgp.0b013e31816c7b54.Peer-Reviewed Original ResearchConceptsDecision-making abilityDecision-making capacityCognitive impairmentMacArthur Competency Assessment ToolExecutive functionMeasure of understandingOverall cognitionAssessment of capacityValid measureAlpha coefficientMedical treatment decisionsCronbach's alpha coefficientGood reliabilityImpairmentMeasuresACEDModerate correlationOlder personsCognitionAssessment toolPersonsAbilityReasoningCaregiversEveryday
2006
Light to Moderate Alcohol Consumption Is Associated With Better Cognitive Function Among Older Male Veterans Receiving Primary Care
Reid MC, Van Ness PH, Hawkins KA, Towle V, Concato J, Guo Z. Light to Moderate Alcohol Consumption Is Associated With Better Cognitive Function Among Older Male Veterans Receiving Primary Care. Journal Of Geriatric Psychiatry And Neurology 2006, 19: 98-105. PMID: 16690995, DOI: 10.1177/0891988706286513.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionOlder male veteransBetter cognitive functionCognitive functionFormer drinkersPrimary careMale veteransModerate drinkingAlcohol consumptionBetter cognitive performanceOlder personsVeterans Administration primary care clinicCognitive performancePrimary care clinicsHopkins Verbal Learning TestCare clinicsVerbal Learning TestMean ageCurrent drinkersMedical statusOlder menReference groupLifetime useLearning TestDrinkers
2002
Relationship between Alcohol Consumption and Folstein Mini-Mental Status Examination Scores among Older Cognitively Impaired Adults
Reid MC, Maciejewski PK, Hawkins KA, Bogardus ST. Relationship between Alcohol Consumption and Folstein Mini-Mental Status Examination Scores among Older Cognitively Impaired Adults. Journal Of Geriatric Psychiatry And Neurology 2002, 15: 31-37. PMID: 11936241, DOI: 10.1177/089198870201500107.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceAbuse/dependenceCognitive screenMMSE subscoresLower total MMSE scoresMMSE scoresDistinctive cognitive profileCognitive impairmentBrief cognitive screenAdverse cognitive outcomesTotal MMSE scoreAlcohol historyCognitive measuresCognitive domainsCognitive profileAlcohol consumptionMini - mental status examination testMini-Mental Status Examination scoreCognitive outcomesAlcohol abuse/dependence disordersImpaired adultsCurrent alcohol intakeMiddle-aged adultsSignificant alcohol historyComprehensive geriatric assessment