2024
Human brain state dynamics are highly reproducible and associated with neural and behavioral features
Lee K, Ji J, Fonteneau C, Berkovitch L, Rahmati M, Pan L, Repovš G, Krystal J, Murray J, Anticevic A. Human brain state dynamics are highly reproducible and associated with neural and behavioral features. PLOS Biology 2024, 22: e3002808. PMID: 39316635, PMCID: PMC11421804, DOI: 10.1371/journal.pbio.3002808.Peer-Reviewed Original ResearchConceptsCo-activation patternsResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingBehavioral featuresNeural variationsMoment-to-moment changesSingle-subject levelBrain state dynamicsEmotion regulationHealthy young adultsBehavioral phenotypesCognitive functionSubstance useNeural activityNeuroimaging markersNeural featuresYoung adultsMagnetic resonance imagingCo-activationResonance imagingCo-variationNeuroimagingIndividualsEmotionsFunctional outcomes
2022
Arousal impacts distributed hubs modulating the integration of brain functional connectivity
Lee K, Horien C, O’Connor D, Garand-Sheridan B, Tokoglu F, Scheinost D, Lake EMR, Constable RT. Arousal impacts distributed hubs modulating the integration of brain functional connectivity. NeuroImage 2022, 258: 119364. PMID: 35690257, PMCID: PMC9341222, DOI: 10.1016/j.neuroimage.2022.119364.Peer-Reviewed Original Research
2021
An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation
Cross NE, Pomares FB, Nguyen A, Perrault AA, Jegou A, Uji M, Lee K, Razavipour F, Bin Ka’b Ali O, Aydin U, Benali H, Grova C, Dang-Vu TT. An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation. PLOS Biology 2021, 19: e3001232. PMID: 34735431, PMCID: PMC8568176, DOI: 10.1371/journal.pbio.3001232.Peer-Reviewed Original ResearchConceptsSleep-deprived stateSleep deprivationCortical networksFunctional magnetic resonance imaging (fMRI) scansLarge-scale cortical networksCognitive impairmentSleep-deprived brainNight of SDHomeostatic sleep pressureExecutive tasksCognitive performanceTask performanceCognitive changesRegular nightBrain activityCognitive functionCognitive deficitsNetwork integrationInformation processingSleep pressureCortical activityBidirectional effectsConnectivity changesInterindividual differencesNonrapid eye movement sleep
2019
Automatic classification and removal of structured physiological noise for resting state functional connectivity MRI analysis
Lee K, Khoo HM, Fourcade C, Gotman J, Grova C. Automatic classification and removal of structured physiological noise for resting state functional connectivity MRI analysis. Magnetic Resonance Imaging 2019, 58: 97-107. PMID: 30695721, DOI: 10.1016/j.mri.2019.01.019.Peer-Reviewed Original ResearchConceptsReal dataNumber of atomsSubject-specific thresholdFunctional connectivity MRI analysisState networksAutomatic removal methodSpatial priorsSet of voxelsBootstrap resamplingSparse dictionary learningStepwise regression procedureNoiseHub analysisRegression procedureInter-network communicationNew methodAtomsBand-pass filteringTemporal correlationFluctuationsPriorsSparsityDictionary learningNetworkWhole-brain signals
2018
Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy
Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C. Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy. NeuroImage Clinical 2018, 20: 71-84. PMID: 30094158, PMCID: PMC6070692, DOI: 10.1016/j.nicl.2018.06.029.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyLobe epilepsyState functional MRIDefault mode networkHealthy controlsBrain network hubsConnector hubsAbnormal hippocampusMotor networkHippocampal networkBrain regionsSalience networkFunctional MRIEpilepsyEpileptic subjectsMode networkLateralizationBrain networksDefault modeAbnormalitiesPathological disruptionHub reorganizationFunctional networksDisruption
2016
SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity
Lee K, Lina JM, Gotman J, Grova C. SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity. NeuroImage 2016, 134: 434-449. PMID: 27046111, DOI: 10.1016/j.neuroimage.2016.03.049.Peer-Reviewed Original Research
2015
Sparse SPM: Group Sparse-dictionary learning in SPM framework for resting-state functional connectivity MRI analysis
Lee YB, Lee J, Tak S, Lee K, Na DL, Seo SW, Jeong Y, Ye JC, Initiative T. Sparse SPM: Group Sparse-dictionary learning in SPM framework for resting-state functional connectivity MRI analysis. NeuroImage 2015, 125: 1032-1045. PMID: 26524138, DOI: 10.1016/j.neuroimage.2015.10.081.Peer-Reviewed Original ResearchConceptsSparse graph modelIndependency assumptionEstimation problemDesign matrixSparse dictionary learningSame temporal dynamicsGraph modelResting-state functional connectivity MRI analysesVariance assumptionLocal network structureSparse combinationTheoretical analysisFunctional connectivity MRI analysisGraph theoretical analysisLocal dynamicsSPM frameworkParameter mappingSummary statisticsDynamicsGlobal brain dynamicsBrain dynamicsGroup-level inferencesLocal connectivityAforementioned individualsStatistical parameter mapping
2010
A Data-Driven Sparse GLM for fMRI Analysis using Sparse Dictionary Learning with MDL Criterion
Lee K, Tak S, Ye JC. A Data-Driven Sparse GLM for fMRI Analysis using Sparse Dictionary Learning with MDL Criterion. IEEE Transactions On Medical Imaging 2010, 30: 1076-1089. PMID: 21138799, DOI: 10.1109/tmi.2010.2097275.Peer-Reviewed Original ResearchQuantification of CMRO2 without hypercapnia using simultaneous near-infrared spectroscopy and fMRI measurements
Tak S, Jang J, Lee K, Ye JC. Quantification of CMRO2 without hypercapnia using simultaneous near-infrared spectroscopy and fMRI measurements. Physics In Medicine And Biology 2010, 55: 3249-3269. PMID: 20479515, DOI: 10.1088/0031-9155/55/11/017.Peer-Reviewed Original ResearchConceptsCerebral blood flowPrimary motor cortexCerebral blood volumeFunctional MRIMotor cortexAverage cerebral blood flowBlood oxygenation level-dependent (BOLD) signalCerebral metabolic rateLevel-dependent signalNeurovascular couplingBlood flowBlood volumeBOLD changesFMRI measurementsHypercapniaCortexMain target regionMetabolic rateGroup averagesActivation mapsCMRO2Physiological componentsFinger