2015
Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings
Geliebter A, Benson L, Pantazatos SP, Hirsch J, Carnell S. Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings. Appetite 2015, 96: 195-202. PMID: 26275334, PMCID: PMC4684801, DOI: 10.1016/j.appet.2015.08.009.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexHigh-calorie food cuesNon-BE groupFood cuesNeural responsesPsychophysiologic interactionsOrbitofrontal cortexFunctional connectivityGreater functional connectivityRegional brain activationAnterior cingulate activationHigh energy density foodsAnterior cingulate cortexLow-ED foodsAuditory cuesFMRI scanningActivation differencesBrain activationCingulate activationMore activationSupramarginal gyrusNeuroimaging studiesBE groupObese individualsCingulate cortex
2014
Amodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity
Carnell S, Benson L, Pantazatos SP, Hirsch J, Geliebter A. Amodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity. Obesity 2014, 22: 2370-2378. PMID: 25098957, PMCID: PMC4224976, DOI: 10.1002/oby.20859.Peer-Reviewed Original ResearchConceptsFunctional connectivityObese individualsFood cuesEffect of obesityLow-ED foodsWhole-brain activationGreater functional connectivityLean womenDifferential neural responsesObesogenic environmentMidbrainExcessive foodVTABrain activationNeural responsesObeseFMRI scanningObesityPutamenCerebellumActivationResponseCue modalityIndividualsWomen
2013
Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans
Hinkle W, Cordell M, Leibel R, Rosenbaum M, Hirsch J. Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans. PLOS ONE 2013, 8: e59114. PMID: 23555620, PMCID: PMC3605420, DOI: 10.1371/journal.pone.0059114.Peer-Reviewed Original ResearchConceptsLeptin repletionRight hypothalamusFunctional connectivityFood cuesWeight lossGreater weight lossOrbital frontal cortexDorsal anterior cingulatePsychophysiological interaction analysisPlacebo injectionsObese subjectsObese populationLeptin injectionObese humansWeight maintenanceFrontal cortexAnterior cingulateHypothalamusFrontal poleInteroceptive systemPatient subjectsVisual areasDorsal ACCFood stimuliRepletion
2010
Energy intake in weight-reduced humans
Rosenbaum M, Kissileff HR, Mayer LE, Hirsch J, Leibel RL. Energy intake in weight-reduced humans. Brain Research 2010, 1350: 95-102. PMID: 20595050, PMCID: PMC2926239, DOI: 10.1016/j.brainres.2010.05.062.Peer-Reviewed Original ResearchConceptsEnergy intakeWeight lossSustained weight lossSuccessful weight reductionAdipocyte-derived hormoneBody weight maintenanceEnergy expenditureBody composition changesBody energy storesWeight maintenanceBody fatnessBody weightNeuronal signalingIntakeWeight reductionBasis of weightEnergy storesMultiple changesLeptinWeightHormoneResponse
2005
Responsivity to food stimuli in obese and lean binge eaters using functional MRI
Geliebter A, Ladell T, Logan M, Schweider T, Sharafi M, Hirsch J. Responsivity to food stimuli in obese and lean binge eaters using functional MRI. Appetite 2005, 46: 31-35. PMID: 16364498, DOI: 10.1016/j.appet.2005.09.002.Peer-Reviewed Original ResearchConceptsObese binge eatersBinge eatersAuditory stimuliFood stimuliNon-food stimuliRandom effects group analysisVentral premotor cortexRight premotor areaNon-binge eatersBinge foodsRight-handed womanFMRI scannerConcurrent motorFunctional neuroimagingFunctional MRIPremotor cortexPremotor areasBrain areasStimuliMotor behaviorEatersType foodsIndividual subjectsGroup analysisBinge