2018
Functional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation
Galgano J, Pantazatos S, Allen K, Yanagihara T, Hirsch J. Functional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation. Brain Research 2018, 1707: 184-189. PMID: 30500402, PMCID: PMC7434632, DOI: 10.1016/j.brainres.2018.11.040.Peer-Reviewed Original ResearchConceptsPeriaqueductal gray regionPsychophysiological interaction analysisFunctional connectivityDiffusion tensor imaging (DTI) analysisTrend-level evidenceNeural mechanismsBilateral auditory corticesGreater functional connectivityAmygdala couplingWhole-brain resultsDorsomedial prefrontal cortexLimbic systemMotor areaAmygdala clustersAuditory cortexLaryngeal musculatureHealthy adultsPrefrontal cortexNeuroimaging studiesNeural activityVoice disordersStructural connectivityGray regionCortexMovement paradigm
2014
Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study
Karten A, Hirsch J. Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study. Journal Of Autism And Developmental Disorders 2014, 45: 1905-1914. PMID: 25526952, PMCID: PMC4441908, DOI: 10.1007/s10803-014-2344-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNegative BOLD responseASD participantsReceptive languageLanguage disabilitySpectrum disorderNeural deactivationInhibitory processesFunctional connectivityFunctional magnetic resonance imagingBlood oxygen level-dependent (BOLD) responseSuperior temporal gyrusFunctional MRI studyLevel-dependent responsesNeural mechanismsPassive listeningTemporal gyrusBOLD responseControl participantsParticipantsLanguageMagnetic resonance imagingExcitatory processesMRI studiesConnectivity
2013
Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment
Pantazatos SP, Talati A, Schneier FR, Hirsch J. Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment. Neuropsychopharmacology 2013, 39: 425-434. PMID: 24084831, PMCID: PMC3870777, DOI: 10.1038/npp.2013.211.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderFunctional connectivityAnxiety disordersFace perceptionTemporal poleFunctional magnetic resonance imaging studyPanic disorderSpecific anxiety disordersIndependent replication sampleHippocampal functional connectivityMagnetic resonance imaging studyFace processingPerceptual tasksResonance imaging studyBrain activationSAD diagnosisReplication sampleHIGH-SADSAD samplesSimilar tasksDisorder-specific biomarkersFC featuresSymptom severityAnterior temporalPerceptionShared space, separate processes: Neural activation patterns for auditory description and visual object naming in healthy adults
Hamberger MJ, Habeck CG, Pantazatos SP, Williams AC, Hirsch J. Shared space, separate processes: Neural activation patterns for auditory description and visual object naming in healthy adults. Human Brain Mapping 2013, 35: 2507-2520. PMID: 23918095, PMCID: PMC4091775, DOI: 10.1002/hbm.22345.Peer-Reviewed Original ResearchConceptsVisual namingVisual objectsAuditory descriptionActivation patternsPosterior temporal activationNeural activation patternsCommon neural substrateTask-related differencesTask-specific regionsPosterior temporal regionsAnterior temporal cortexTypes of tasksCortical stimulation studiesTemporo-parietal regionsTemporal lobe epilepsy patientsHealthy adultsCognitive scientistsStandard univariate analysisNeural processesNeural substratesFunctional neuroimagingCerebral organizationTask specificityTemporal cortexLeft posterior
2012
Frontal–Occipital Connectivity During Visual Search
Pantazatos SP, Yanagihara TK, Zhang X, Meitzler T, Hirsch J. Frontal–Occipital Connectivity During Visual Search. Brain Connectivity 2012, 2: 164-175. PMID: 22708993, PMCID: PMC3621345, DOI: 10.1089/brain.2012.0072.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFrontal LobeHumansMaleNeural PathwaysOccipital LobePhotic StimulationVisual PerceptionConceptsLateral occipital cortexVisual searchVisual regionsPrefrontal cortexCategory-selective visual regionsFunctional magnetic resonance imagingVentromedial prefrontal cortexSimilar neural mechanismsVisual search processDynamic causal modelingMedial prefrontal cortexComplex natural scenesMultiple task-related componentsSpatial independent component analysisTask-related componentsVisual imageryPsychophysiological interactionNeural mechanismsSearch taskObject categoriesComplex search tasksCausal modelingConnectivity findingsFrontal regionsFunctional connectivityConceptual representations of perceptual knowledge
Smith EE, Myers N, Sethi U, Pantazatos S, Yanagihara T, Hirsch J. Conceptual representations of perceptual knowledge. Cognitive Neuropsychology 2012, 29: 237-248. PMID: 22994286, PMCID: PMC3516296, DOI: 10.1080/02643294.2012.706218.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusFunctional magnetic resonance imagingFusiform gyrusPerceptual propertiesPerceptual knowledgeLeft inferior frontal gyrusLeft fusiform gyrusMiddle temporal gyrusPerceptual processingAmodal processesModality-specific mannerSemantic memoryBehavioral performanceFrontal gyrusThompson-SchillConceptual representationKan et alVerbal statementsGyrusParticipantsProcessingMagnetic resonance imagingRepresentationBarsalouMemoryCortical functional connectivity decodes subconscious, task-irrelevant threat-related emotion processing
Pantazatos SP, Talati A, Pavlidis P, Hirsch J. Cortical functional connectivity decodes subconscious, task-irrelevant threat-related emotion processing. NeuroImage 2012, 61: 1355-1363. PMID: 22484206, PMCID: PMC3393600, DOI: 10.1016/j.neuroimage.2012.03.051.Peer-Reviewed Original ResearchConceptsFunctional connectivityAffective stimuliCortical-subcortical functional connectivityFearful face processingFear-related stimuliAmygdala functional connectivityMiddle temporal gyrusCortical structuresKey limbic regionsFace processingEmotion processingFear conditionFear processingSubconscious processingAngular gyrusTemporal gyrusCortical functional connectivityRight amygdalaLimbic regionsFC featuresStimuliGyrusProcessingTraining dataPrecuneusNeural systems for speech and song in autism
Lai G, Pantazatos SP, Schneider H, Hirsch J. Neural systems for speech and song in autism. Brain 2012, 135: 961-975. PMID: 22298195, PMCID: PMC3286324, DOI: 10.1093/brain/awr335.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgingAnisotropyAttentionAutistic DisorderBrainChildDiffusion Tensor ImagingFemaleFunctional LateralityHead MovementsHumansImage Processing, Computer-AssistedInterview, PsychologicalLanguageMagnetic Resonance ImagingMaleMusicNerve NetNeural PathwaysNeuropsychological TestsPhotic StimulationRecruitment, NeurophysiologicalSpeechYoung AdultConceptsInferior frontal gyrusLeft inferior frontal gyrusFrontal gyrusAutistic childrenNeural systemsArcuate fasciculusFunctional magnetic resonanceSuperior temporal gyrusAge-matched control childrenLeft arcuate fasciculusPassive auditory stimulationMusic abilityLanguage disabilitySong conditionTemporal gyrusSpeech stimulationAuditory stimulationAutismFunctional connectivityNeural organizationBrain regionsSpeechControl childrenGyrusAutistic
2011
Distinct but overlapping neural networks subserve depression and insecure attachment
Galynker II, Yaseen ZS, Katz C, Zhang X, Jennings-Donovan G, Dashnaw S, Hirsch J, Mayberg H, Cohen LJ, Winston A. Distinct but overlapping neural networks subserve depression and insecure attachment. Social Cognitive And Affective Neuroscience 2011, 7: 896-908. PMID: 22037687, PMCID: PMC3501706, DOI: 10.1093/scan/nsr074.Peer-Reviewed Original ResearchConceptsSub-cortical activityBeck Depression InventoryEffect of depressionLevel-dependent responsesSub-cortical componentsCortico-striatoCortical effectsDepression scoresThalamic circuitsDepression InventoryCortical encodingDepressionFMRI scanningBrain activityNeural mechanismsPsychotherapeutic outcomeInsecure attachmentScoresSame circuitryFemale strangerMultiple linear regressionLater attachmentLinear regressionPatientsAttachment insecuritySelective Reduction in Neural Responses to High Calorie Foods Following Gastric Bypass Surgery
Ochner CN, Kwok Y, Conceição E, Pantazatos SP, Puma LM, Carnell S, Teixeira J, Hirsch J, Geliebter A. Selective Reduction in Neural Responses to High Calorie Foods Following Gastric Bypass Surgery. Annals Of Surgery 2011, 253: 502-507. PMID: 21169809, PMCID: PMC3128512, DOI: 10.1097/sla.0b013e318203a289.Peer-Reviewed Original ResearchConceptsRYGB surgeryHigh-calorie foodsPostsurgical reductionFood cuesCaloric intakeLow-calorie food cuesCommon bariatric proceduresPost-RYGB surgeryGastric bypass surgeryBrain activationNeural activationVerbal rating scaleCaloric densityNeural responsesMesolimbic reward pathwayFunctional magnetic resonance imagingMagnetic resonance imagingMechanism of actionMalabsorptive mechanismsBariatric proceduresGastric bypassBypass surgeryFemale patientsGut peptidesPostbariatric surgery
2009
Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze
Schneier FR, Kent JM, Star A, Hirsch J. Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze. Psychiatry Research 2009, 173: 248-250. PMID: 19628377, PMCID: PMC2745296, DOI: 10.1016/j.pscychresns.2008.06.004.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderEye gazeAnxiety disordersPathophysiology of SADSubmissive behaviorFunctional magnetic resonance imagingDirect eye gazeAverted gazeDirect gazeNeural responsesPrefrontal cortexSAD subjectsAnterior cingulateNeural circuitryNeural activityBrain regionsGazeMagnetic resonance imagingHealthy volunteersResonance imagingDisordersInsulaCingulateFearSignificant differences
2008
Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring
Ferrera V, Grinband J, Teichert T, Pestilli F, Dashnaw S, Hirsch J. Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring. Journal Of Visualized Experiments 2008, 992. PMID: 19066528, PMCID: PMC2731772, DOI: 10.3791/992.Peer-Reviewed Original ResearchMeSH KeywordsBrainDecision MakingEye MovementsHumansMagnetic Resonance ImagingNeural PathwaysReinforcement, PsychologyConceptsHeart rateFMRI signalsAutonomic pathwaysFunctional brain imagingSimple perceptual tasksNeural circuitsFunctional imagingBrain imagingNeural activityPerceptual tasksUse of reinforcersAversive reinforcementSignal changesHead movementsReinforcer deliveryImagingPhysiological monitoringReinforcersAirpuffBrainA neurology of belief
Sacks O, Hirsch J. A neurology of belief. Annals Of Neurology 2008, 63: 129-130. PMID: 18306392, DOI: 10.1002/ana.21378.Peer-Reviewed Original Research
2007
Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters
Egner T, Etkin A, Gale S, Hirsch J. Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters. Cerebral Cortex 2007, 18: 1475-1484. PMID: 17940084, DOI: 10.1093/cercor/bhm179.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingConflict, PsychologicalEmotionsFemaleHumansMaleNerve NetNeural PathwaysPhotic StimulationConceptsTask-relevant stimuliEmotional distractersTask-irrelevant emotional stimuliAnterior cingulateSensory cortexTask-irrelevant stimuliLateral prefrontal cortexDorsal anterior cingulateFunctional magnetic resonanceRostral anterior cingulateCognitive controlConflict monitoringEmotional stimuliStimulus representationsAmygdalar responsesEmotional controlEnhanced processingResolve ConflictsEmotional conflictNeuroanatomical networksPrefrontal cortexDistractersResolution of conflictsBiasing mechanismHuman brain
2006
Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala
Etkin A, Egner T, Peraza DM, Kandel ER, Hirsch J. Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala. Neuron 2006, 51: 871-882. PMID: 16982430, DOI: 10.1016/j.neuron.2006.07.029.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexAnterior cingulate cortexFunctional magnetic resonance imagingCingulate cortexEmotional conflictAmygdalar activityRostral cingulate cortexMagnetic resonance imagingDorsolateral prefrontal cortexRostral cingulateResonance imagingPrefrontal cortexModulating activityCortexConflict taskSalient stimuliNeural activityNeural mechanismsMental functioningActivationConflictActivityAmygdalaNeocortical Connectivity during Episodic Memory Formation
Summerfield C, Greene M, Wager T, Egner T, Hirsch J, Mangels J. Neocortical Connectivity during Episodic Memory Formation. PLOS Biology 2006, 4: e128. PMID: 16605307, PMCID: PMC1436028, DOI: 10.1371/journal.pbio.0040128.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMemoryNeocortexNeural PathwaysConceptsEpisodic encodingPerceptual informationEpisodic memory tracesLeft dorsolateral prefrontal cortexNew episodic memoriesEpisodic memory formationFunctional magnetic resonanceDorsolateral prefrontal cortexExtrastriate visual cortexEpisodic memoryMemory tracesBrain mechanismsSensory representationsVisual stimuliPrefrontal cortexConnectivity analysisMemory formationVisual cortexNeocortical connectivityEncodingHemodynamic signalsCortexReliable predictorMemorySelective response
2005
Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information
Egner T, Hirsch J. Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information. Nature Neuroscience 2005, 8: 1784-1790. PMID: 16286928, DOI: 10.1038/nn1594.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBehaviorBrain MappingCerebral CortexCerebrovascular CirculationCognitionConflict, PsychologicalDecision MakingFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysNeuropsychological TestsPattern Recognition, VisualPhotic StimulationPrefrontal CortexReaction TimeVisual CortexVolitionConceptsTask-relevant informationCognitive control mechanismsTask-irrelevant informationCognitive controlTask-relevant stimulus informationCognitive control systemConflict resolutionDorsolateral prefrontal cortexHuman visual cortexAttentional biasingFace processingPerceptual processingFace stimuliStroop taskNeural representationStimulus informationResponse tendenciesOccurrence of conflictsHigh conflictPrefrontal cortexProminent modelsCortical responsesTrial levelCortical amplificationVisual cortex