2021
Bidirectional Connectivity Between Broca's Area and Wernicke's Area During Interactive Verbal Communication
Ono Y, Zhang X, Noah JA, Dravida S, Hirsch J. Bidirectional Connectivity Between Broca's Area and Wernicke's Area During Interactive Verbal Communication. Brain Connectivity 2021, 12: 210-222. PMID: 34128394, PMCID: PMC9058861, DOI: 10.1089/brain.2020.0790.Peer-Reviewed Original ResearchConceptsWernicke's areaNeural mechanismsBroca's areaDirectional connectivityHealthy adult participantsHemodynamic responseBidirectional connectivityFunctional connectivityNeural modulationBrainNeuronal informationSpeech areasNeural activityAdult participantsBrocaContrast findingsHuman brainImpact statementNeural dynamicsBrain modelFindingsWernicke'sSocial functionGranger causality analysisVerbal condition
2018
A cross-brain neural mechanism for human-to-human verbal communication
Hirsch J, Noah J, Zhang X, Dravida S, Ono Y. A cross-brain neural mechanism for human-to-human verbal communication. Social Cognitive And Affective Neuroscience 2018, 13: 907-920. PMID: 30137601, PMCID: PMC6137318, DOI: 10.1093/scan/nsy070.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusInteractive brain hypothesisNeural mechanismsSocial interactionBrain hypothesisCanonical language areasHuman verbal communicationNon-interactive conditionDynamic social interactionsObject NamingSocial cuesInterpersonal informationBrain substratesDescription taskTemporal gyrusBroca's areaLanguage areasWernicke's areaNeural activitySubcentral areaVerbal communicationNatural settingsTheoretical frameworkGeneral theoretical frameworkDeoxyhemoglobin signal
2017
Neural correlates of conflict between gestures and words: A domain-specific role for a temporal-parietal complex
Noah JA, Dravida S, Zhang X, Yahil S, Hirsch J. Neural correlates of conflict between gestures and words: A domain-specific role for a temporal-parietal complex. PLOS ONE 2017, 12: e0173525. PMID: 28278240, PMCID: PMC5344449, DOI: 10.1371/journal.pone.0173525.Peer-Reviewed Original ResearchConceptsTemporal-parietal junctionDorsolateral prefrontal cortexRight temporal-parietal junctionRight dorsolateral prefrontal cortexLeft dorsolateral prefrontal cortexSuperior temporal gyrusColor taskConflict taskIncongruent trialsSocial cuesGesture tasksSupramarginal gyrusBehavioral interference effectDomain-general mechanismsUnderlying neural processesReceptive language areasHuman social behaviorAuditory association cortexDomain-specific rolesFrontal eye fieldConflict processing mechanismCongruent trialsGestural cuesNeural correlatesNeural processes
2014
Negative Blood Oxygen Level Dependent Signals During Speech Comprehension
Moreno D, Schiff ND, Hirsch J. Negative Blood Oxygen Level Dependent Signals During Speech Comprehension. Brain Connectivity 2014, 5: 232-244. PMID: 25412406, PMCID: PMC4432885, DOI: 10.1089/brain.2014.0272.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependent (BOLD) signalSpeech conditionsLevel-dependent signalBOLD signalSpeech comprehensionResting baselineNatural speechComprehension of speechCanonical language areasLanguage-related tasksNatural speech conditionNegative BOLD responseReceptive languageLanguage tasksPassive listeningComprehension studiesFrontoparietal regionsLanguage areasSame stimuliBOLD responseComprehensionBrain regionsSame speechBrief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study
Karten A, Hirsch J. Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study. Journal Of Autism And Developmental Disorders 2014, 45: 1905-1914. PMID: 25526952, PMCID: PMC4441908, DOI: 10.1007/s10803-014-2344-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNegative BOLD responseASD participantsReceptive languageLanguage disabilitySpectrum disorderNeural deactivationInhibitory processesFunctional connectivityFunctional magnetic resonance imagingBlood oxygen level-dependent (BOLD) responseSuperior temporal gyrusFunctional MRI studyLevel-dependent responsesNeural mechanismsPassive listeningTemporal gyrusBOLD responseControl participantsParticipantsLanguageMagnetic resonance imagingExcitatory processesMRI studiesConnectivity
2012
Neural systems for speech and song in autism
Lai G, Pantazatos SP, Schneider H, Hirsch J. Neural systems for speech and song in autism. Brain 2012, 135: 961-975. PMID: 22298195, PMCID: PMC3286324, DOI: 10.1093/brain/awr335.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgingAnisotropyAttentionAutistic DisorderBrainChildDiffusion Tensor ImagingFemaleFunctional LateralityHead MovementsHumansImage Processing, Computer-AssistedInterview, PsychologicalLanguageMagnetic Resonance ImagingMaleMusicNerve NetNeural PathwaysNeuropsychological TestsPhotic StimulationRecruitment, NeurophysiologicalSpeechYoung AdultConceptsInferior frontal gyrusLeft inferior frontal gyrusFrontal gyrusAutistic childrenNeural systemsArcuate fasciculusFunctional magnetic resonanceSuperior temporal gyrusAge-matched control childrenLeft arcuate fasciculusPassive auditory stimulationMusic abilityLanguage disabilitySong conditionTemporal gyrusSpeech stimulationAuditory stimulationAutismFunctional connectivityNeural organizationBrain regionsSpeechControl childrenGyrusAutistic
2006
Functional Neuroimaging Applications for Assessment and Rehabilitation Planning in Patients With Disorders of Consciousness
Giacino JT, Hirsch J, Schiff N, Laureys S. Functional Neuroimaging Applications for Assessment and Rehabilitation Planning in Patients With Disorders of Consciousness. Archives Of Physical Medicine And Rehabilitation 2006, 87: 67-76. PMID: 17140882, DOI: 10.1016/j.apmr.2006.07.272.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessHigher-order association corticesStudy of patientsRestoration of functionPrimary cortical areasFunctional magnetic resonanceFunctional neuroimaging techniquesFunctional neuroimaging protocolsPotential clinical applicationsPathophysiologic mechanismsPattern of activationPatient characterizationPositron emission tomography activation studyDifferential diagnosisPrognostic assessmentDisconnection syndromeCortical areasAssociation cortexLarge-scale cortical networksPatientsNeuroimaging protocolVegetative stateNeuroimaging techniquesConscious stateCortical networks
2005
fMRI reveals large-scale network activation in minimally conscious patients
Schiff N, Rodriguez-Moreno D, Kamal A, Kim K, Giacino J, Plum F, Hirsch J. fMRI reveals large-scale network activation in minimally conscious patients. Neurology 2005, 64: 514-523. PMID: 15699384, DOI: 10.1212/01.wnl.0000150883.10285.44.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAttentionAuditory CortexAwarenessCerebral HemorrhageCraniocerebral TraumaEncephalomalaciaFixation, OcularHumansLanguageMagnetic Resonance ImagingMalePersistent Vegetative StatePhysical StimulationSomatosensory CortexTemporal LobeTouchVerbal BehaviorWounds, NonpenetratingConceptsCognitive functionCortical activityLanguage-related tasksResidual cognitive functionMiddle temporal gyrusTactile stimulationMeaningless stimuliActive cortical networkConscious stateLanguage stimulationNeurobiological correlatesLanguage functionTemporal gyrusBehavioral evidenceMCS patientsCortical systemsLinguistic contentAuditory stimulationCortical networksLanguage processingCerebral networksNetwork activationCortical responsesCommunication abilityFMRI mapsFunctional neuroimaging during altered states of consciousness: how and what do we measure?
Hirsch J. Functional neuroimaging during altered states of consciousness: how and what do we measure? Progress In Brain Research 2005, 150: 25-590. PMID: 16186013, DOI: 10.1016/s0079-6123(05)50003-7.Peer-Reviewed Original ResearchConceptsCognitive processesFunctional neuroimagingDisorders of consciousnessPassive stimulationLanguage-related tasksFunctional magnetic resonanceSpecific traumatic eventStudy of consciousnessFunctional brain activityAltered statesAffective systemsCognitive systemNeural processesTraumatic eventsNeurocognitive healthBrain activitySensory-motor functionParadigm selectionMotor systemVolitional tasksCortical functionExperimental manipulationTaskBrain injuryTemporal sequence
2000
An Integrated Functional Magnetic Resonance Imaging Procedure for Preoperative Mapping of Cortical Areas Associated with Tactile, Motor, Language, and Visual Functions
Hirsch J, Ruge M, Kim K, Correa D, Victor J, Relkin N, Labar D, Krol G, Bilsky M, Souweidane M, DeAngelis L, Gutin P. An Integrated Functional Magnetic Resonance Imaging Procedure for Preoperative Mapping of Cortical Areas Associated with Tactile, Motor, Language, and Visual Functions. Neurosurgery 2000, 47: 711. PMID: 10981759, DOI: 10.1097/00006123-200009000-00037.Peer-Reviewed Original ResearchConceptsIntraoperative electrophysiological measurementsVisual field examinationVisual functionHealthy volunteersCentral sulcusVisual cortexFMRI mapsWernicke's areaFunctional magnetic resonance imaging (fMRI) taskDirect cortical stimulationFunctional magnetic resonance imaging (fMRI) procedureBroca's areaField examinationElectrophysiological measurementsSurgical patientsSurgical riskCortical stimulationPreoperative mappingSurgical routeWada testCortical areasElectrophysiological proceduresMagnetic resonance imaging (MRI) proceduresMultiple critical functionsPreoperative map
1999
Concordance between Functional Magnetic Resonance Imaging and Intraoperative Language Mapping
Ruge M, Victor J, Hosain S, Correa D, Relkin N, Tabar V, Brennan C, Gutin P, Hirsch J. Concordance between Functional Magnetic Resonance Imaging and Intraoperative Language Mapping. Stereotactic And Functional Neurosurgery 1999, 72: 95-102. PMID: 10853058, DOI: 10.1159/000029706.Peer-Reviewed Original ResearchConceptsDirect cortical stimulationIntraoperative electrophysiologyCortical stimulationSensorimotor cortexIntraoperative language mappingFunctional magnetic resonance imagingMagnetic resonance imagingSSEP recordingsLocalization of functionMotor cortexIntraoperative localizationPreoperative toolResonance imagingLanguage mappingCortexWernicke's areaElectrophysiologyFMRIPresent studyStimulationSensorimotor mappingConcordancePatientsBroca
1997
Distinct cortical areas associated with native and second languages
Kim K, Relkin N, Lee K, Hirsch J. Distinct cortical areas associated with native and second languages. Nature 1997, 388: 171-174. PMID: 9217156, DOI: 10.1038/40623.Peer-Reviewed Original ResearchConceptsSecond languageFunctional magnetic resonance imagingMultiple language functionsLanguage-specific regionsCortical areasEssential human capacitiesFrontal cortical areasLanguage acquisitionNative languageBilingual subjectsMultiple languagesDistinct cortical areasLanguageLanguage functionBroca's areaCortical representationHuman capacityHuman brainHuman cortexAcquisition stageSeparation of activitiesMagnetic resonance imagingResonance imagingFundamental questionsAdulthood