2011
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder
Schneier FR, Pomplun M, Sy M, Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research 2011, 194: 271-278. PMID: 22047726, PMCID: PMC3230304, DOI: 10.1016/j.pscychresns.2011.08.006.Peer-Reviewed Original ResearchConceptsParoxetine treatmentInferior parietal lobuleGeneralized social anxiety disorderNeural responsesPosterior cingulateParietal lobuleAnxiety disordersGSAD patientsEye contactMiddle occipital cortexMiddle frontal gyrusFunctional magnetic resonanceSymptomatic improvementHealthy comparison participantsOccipital cortexSocial anxiety disorderSymptom reductionAnterior cingulatePatientsUnmedicated adultsParahippocampal cortexNeural circuitrySupramarginal gyrusFrontal gyrusCingulateSpeech Stimulation during Functional MR Imaging as a Potential Indicator of Autism
Lai G, Schneider HD, Schwarzenberger JC, Hirsch J. Speech Stimulation during Functional MR Imaging as a Potential Indicator of Autism. Radiology 2011, 260: 521-30. PMID: 21628495, DOI: 10.1148/radiol.11101576.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusControl subjectsSpeech stimulationFunctional MR imagingFunctional MR imaging activationFunctional magnetic resonanceAutistic subjectsMR imagingPrimary auditory cortexWilcoxon rank sum testInstitutional review boardMagnetic resonanceSpread of activityTwo-sample t-testRank sum testUnivariate general linear model analysisProspective studyMR evaluationAuditory cortexGeneral linear model analysisControl groupObjective indicatorsTemporal gyrusInformed consentReview board
2008
Neural Integration of Top-Down Spatial and Feature-Based Information in Visual Search
Egner T, Monti JM, Trittschuh EH, Wieneke CA, Hirsch J, Mesulam M. Neural Integration of Top-Down Spatial and Feature-Based Information in Visual Search. Journal Of Neuroscience 2008, 28: 6141-6151. PMID: 18550756, PMCID: PMC6670545, DOI: 10.1523/jneurosci.1262-08.2008.Peer-Reviewed Original ResearchConceptsCue informationVisual searchActivation gainVisual search targetBlood oxygenation level-dependent (BOLD) responseSpatial cue informationLevel-dependent responsesSearch onsetDown biasingSpatial expectancyOculomotor planningIntraparietal sulcusSearch targetSalience mapBOLD responseSearch templateCingulate regionsNeural integrationTarget featuresHuman brainTarget locationSearch performance
2007
Repeated Exposure to Media Violence Is Associated with Diminished Response in an Inhibitory Frontolimbic Network
Kelly CR, Grinband J, Hirsch J. Repeated Exposure to Media Violence Is Associated with Diminished Response in an Inhibitory Frontolimbic Network. PLOS ONE 2007, 2: e1268. PMID: 18060062, PMCID: PMC2092389, DOI: 10.1371/journal.pone.0001268.Peer-Reviewed Original ResearchMeSH KeywordsAdultAggressionAmygdalaAnalysis of VarianceFemaleFrontal LobeHumansLimbic SystemMaleMass MediaViolenceConceptsFunctional magnetic resonance imagingRight lateral orbitofrontal cortexMagnetic resonance imagingLateral orbitofrontal cortexDiminished responsivenessDiminished responseShort-term exposureResonance imagingFrontolimbic networkOrbitofrontal cortexCortical networksNovel findingsExposureResponseCortex
2005
Where Memory Meets Attention: Neural Substrates of Negative Priming
Egner T, Hirsch J. Where Memory Meets Attention: Neural Substrates of Negative Priming. Journal Of Cognitive Neuroscience 2005, 17: 1774-1784. PMID: 16269113, DOI: 10.1162/089892905774589226.Peer-Reviewed Original ResearchConceptsEpisodic retrievalNegative primingStimulus featuresColor-naming Stroop taskRight dorsolateral prefrontal cortexEpisodic memory retrievalSelective attention performanceMemory retrieval functionsEvent-related fMRICurrent target stimulusSelective attention systemNegative priming effectDorsolateral prefrontal cortexStroop taskAttention systemDistractor stimuliMemory retrievalAttention performanceNeurophysiological predictionsTarget stimuliStimulus informationNeural substratesNeural responsesTheoretical accountsPriming effectThe neural correlates and functional integration of cognitive control in a Stroop task
Egner T, Hirsch J. The neural correlates and functional integration of cognitive control in a Stroop task. NeuroImage 2005, 24: 539-547. PMID: 15627596, DOI: 10.1016/j.neuroimage.2004.09.007.Peer-Reviewed Original ResearchConceptsCognitive controlConflict adaptationPsychophysiological interaction analysisStroop taskNeural correlatesFrontal gyrusPrefrontal cortexDistinct fronto-parietal networksEvent-related fMRI dataLow-conflict trialsHigh-conflict trialsFronto-parietal networkLateral prefrontal cortexMiddle frontal gyrusBilateral inferior frontalSuperior frontal gyrusContext-specific modulationInterference taskResponse conflictCognitive tasksConflict effectMotor processesInferior frontalNeural substratesTask performance
1997
Distinct cortical areas associated with native and second languages
Kim K, Relkin N, Lee K, Hirsch J. Distinct cortical areas associated with native and second languages. Nature 1997, 388: 171-174. PMID: 9217156, DOI: 10.1038/40623.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBrain MappingFemaleFrontal LobeHumansLanguageMagnetic Resonance ImagingMaleMultilingualismTemporal LobeConceptsSecond languageFunctional magnetic resonance imagingMultiple language functionsLanguage-specific regionsCortical areasEssential human capacitiesFrontal cortical areasLanguage acquisitionNative languageBilingual subjectsMultiple languagesDistinct cortical areasLanguageLanguage functionBroca's areaCortical representationHuman capacityHuman brainHuman cortexAcquisition stageSeparation of activitiesMagnetic resonance imagingResonance imagingFundamental questionsAdulthood