2014
Amodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity
Carnell S, Benson L, Pantazatos SP, Hirsch J, Geliebter A. Amodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity. Obesity 2014, 22: 2370-2378. PMID: 25098957, PMCID: PMC4224976, DOI: 10.1002/oby.20859.Peer-Reviewed Original ResearchConceptsFunctional connectivityObese individualsFood cuesEffect of obesityLow-ED foodsWhole-brain activationGreater functional connectivityLean womenDifferential neural responsesObesogenic environmentMidbrainExcessive foodVTABrain activationNeural responsesObeseFMRI scanningObesityPutamenCerebellumActivationResponseCue modalityIndividualsWomen
2013
Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment
Pantazatos SP, Talati A, Schneier FR, Hirsch J. Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment. Neuropsychopharmacology 2013, 39: 425-434. PMID: 24084831, PMCID: PMC3870777, DOI: 10.1038/npp.2013.211.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderFunctional connectivityAnxiety disordersFace perceptionTemporal poleFunctional magnetic resonance imaging studyPanic disorderSpecific anxiety disordersIndependent replication sampleHippocampal functional connectivityMagnetic resonance imaging studyFace processingPerceptual tasksResonance imaging studyBrain activationSAD diagnosisReplication sampleHIGH-SADSAD samplesSimilar tasksDisorder-specific biomarkersFC featuresSymptom severityAnterior temporalPerceptionSleep restriction increases the neuronal response to unhealthy food in normal-weight individuals
St-Onge M, Wolfe S, Sy M, Shechter A, Hirsch J. Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals. International Journal Of Obesity 2013, 38: 411-416. PMID: 23779051, PMCID: PMC3883872, DOI: 10.1038/ijo.2013.114.Peer-Reviewed Original ResearchMeSH KeywordsAdultAppetiteBrainBrain MappingCuesEatingFastingFemaleFoodHumansHungerMagnetic Resonance ImagingMalePhotic StimulationRewardSleep DeprivationConceptsFunctional magnetic resonance imagingFood stimuliRight insulaUnhealthy foodsUnhealthy food stimuliNormal-weight individualsMiddle temporal gyrusLevel-dependent activityInferior parietal lobuleSuperior frontal gyrusInsula activityFrontal gyrusGreater activationNeural mechanismsTemporal gyrusParietal lobuleFood intakeOrbitofrontal cortexRestricted sleepSame stimuliNeuronal responsesSleep restrictionNeural systemsBrain rewardShort sleep durationDynamic Coupling Between the Lateral Occipital-Cortex, Default-Mode, and Frontoparietal Networks During Bistable Perception
Karten A, Pantazatos SP, Khalil D, Zhang X, Hirsch J. Dynamic Coupling Between the Lateral Occipital-Cortex, Default-Mode, and Frontoparietal Networks During Bistable Perception. Brain Connectivity 2013, 3: 286-293. PMID: 23510237, PMCID: PMC3685318, DOI: 10.1089/brain.2012.0119.Peer-Reviewed Original Research
2012
Frontal–Occipital Connectivity During Visual Search
Pantazatos SP, Yanagihara TK, Zhang X, Meitzler T, Hirsch J. Frontal–Occipital Connectivity During Visual Search. Brain Connectivity 2012, 2: 164-175. PMID: 22708993, PMCID: PMC3621345, DOI: 10.1089/brain.2012.0072.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFrontal LobeHumansMaleNeural PathwaysOccipital LobePhotic StimulationVisual PerceptionConceptsLateral occipital cortexVisual searchVisual regionsPrefrontal cortexCategory-selective visual regionsFunctional magnetic resonance imagingVentromedial prefrontal cortexSimilar neural mechanismsVisual search processDynamic causal modelingMedial prefrontal cortexComplex natural scenesMultiple task-related componentsSpatial independent component analysisTask-related componentsVisual imageryPsychophysiological interactionNeural mechanismsSearch taskObject categoriesComplex search tasksCausal modelingConnectivity findingsFrontal regionsFunctional connectivityNeural systems for speech and song in autism
Lai G, Pantazatos SP, Schneider H, Hirsch J. Neural systems for speech and song in autism. Brain 2012, 135: 961-975. PMID: 22298195, PMCID: PMC3286324, DOI: 10.1093/brain/awr335.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgingAnisotropyAttentionAutistic DisorderBrainChildDiffusion Tensor ImagingFemaleFunctional LateralityHead MovementsHumansImage Processing, Computer-AssistedInterview, PsychologicalLanguageMagnetic Resonance ImagingMaleMusicNerve NetNeural PathwaysNeuropsychological TestsPhotic StimulationRecruitment, NeurophysiologicalSpeechYoung AdultConceptsInferior frontal gyrusLeft inferior frontal gyrusFrontal gyrusAutistic childrenNeural systemsArcuate fasciculusFunctional magnetic resonanceSuperior temporal gyrusAge-matched control childrenLeft arcuate fasciculusPassive auditory stimulationMusic abilityLanguage disabilitySong conditionTemporal gyrusSpeech stimulationAuditory stimulationAutismFunctional connectivityNeural organizationBrain regionsSpeechControl childrenGyrusAutistic
2011
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder
Schneier FR, Pomplun M, Sy M, Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research 2011, 194: 271-278. PMID: 22047726, PMCID: PMC3230304, DOI: 10.1016/j.pscychresns.2011.08.006.Peer-Reviewed Original ResearchConceptsParoxetine treatmentInferior parietal lobuleGeneralized social anxiety disorderNeural responsesPosterior cingulateParietal lobuleAnxiety disordersGSAD patientsEye contactMiddle occipital cortexMiddle frontal gyrusFunctional magnetic resonanceSymptomatic improvementHealthy comparison participantsOccipital cortexSocial anxiety disorderSymptom reductionAnterior cingulatePatientsUnmedicated adultsParahippocampal cortexNeural circuitrySupramarginal gyrusFrontal gyrusCingulate
2010
Self-face enhances processing of immediately preceding invisible faces
Pannese A, Hirsch J. Self-face enhances processing of immediately preceding invisible faces. Neuropsychologia 2010, 49: 564-573. PMID: 21168427, DOI: 10.1016/j.neuropsychologia.2010.12.019.Peer-Reviewed Original ResearchAdaptation, PhysiologicalAdultBrainCalibrationCuesData Interpretation, StatisticalDiscrimination, PsychologicalFaceFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetOxygenParietal LobePerceptual MaskingPhotic StimulationPsychomotor PerformanceReaction TimeRecognition, PsychologySex CharacteristicsVisual PerceptionYoung Adult
2009
Neural Mechanisms of Grief Regulation
Freed PJ, Yanagihara TK, Hirsch J, Mann JJ. Neural Mechanisms of Grief Regulation. Biological Psychiatry 2009, 66: 33-40. PMID: 19249748, PMCID: PMC2782609, DOI: 10.1016/j.biopsych.2009.01.019.Peer-Reviewed Original Research
2008
Comparison of contrast-response functions from multifocal visual-evoked potentials (mfVEPs) and functional MRI responses
Park JC, Zhang X, Ferrera J, Hirsch J, Hood DC. Comparison of contrast-response functions from multifocal visual-evoked potentials (mfVEPs) and functional MRI responses. Journal Of Vision 2008, 8: 8-8. PMID: 19146350, PMCID: PMC2987574, DOI: 10.1167/8.10.8.Peer-Reviewed Original ResearchConceptsBOLD fMRI responsesMultifocal visual-evoked potentialsContrast response functionsVisual-evoked potentialsFMRI responsesNeural activityFunctional MRI responsesBOLD fMRI signalMonocular mfVEPRetinotopic mapMRI responseV1 areaPattern stimuliBOLD responseFMRI signalsSame stimuliSubjectsResponseV1MfVEPStimuliMfVEPsCortexThe dynamics of deductive reasoning: An fMRI investigation
Rodriguez-Moreno D, Hirsch J. The dynamics of deductive reasoning: An fMRI investigation. Neuropsychologia 2008, 47: 949-961. PMID: 18835284, DOI: 10.1016/j.neuropsychologia.2008.08.030.Peer-Reviewed Original ResearchConceptsDeductive reasoningReasoning processParietal regionsEvent-related fMRISupramodal networkPrevious imaging studiesNeural correlatesFMRI investigationOccipital complexLanguage areasBilateral caudate nucleusInformation processingReasoningSecond premiseImaging studiesTraditional focusCaudate nucleusSubstantive differencesFMRISubsequent conclusionsTime courseScientific investigationPhilosophical discussionCorrelatesTime pointsNeural Integration of Top-Down Spatial and Feature-Based Information in Visual Search
Egner T, Monti JM, Trittschuh EH, Wieneke CA, Hirsch J, Mesulam M. Neural Integration of Top-Down Spatial and Feature-Based Information in Visual Search. Journal Of Neuroscience 2008, 28: 6141-6151. PMID: 18550756, PMCID: PMC6670545, DOI: 10.1523/jneurosci.1262-08.2008.Peer-Reviewed Original ResearchConceptsCue informationVisual searchActivation gainVisual search targetBlood oxygenation level-dependent (BOLD) responseSpatial cue informationLevel-dependent responsesSearch onsetDown biasingSpatial expectancyOculomotor planningIntraparietal sulcusSearch targetSalience mapBOLD responseSearch templateCingulate regionsNeural integrationTarget featuresHuman brainTarget locationSearch performanceA multiplicative model for spatial interaction in the human visual cortex
Zhang X, Park JC, Salant J, Thomas S, Hirsch J, Hood DC. A multiplicative model for spatial interaction in the human visual cortex. Journal Of Vision 2008, 8: 4-4. PMID: 18831627, PMCID: PMC2987578, DOI: 10.1167/8.8.4.Peer-Reviewed Original ResearchLeptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli
Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli. Journal Of Clinical Investigation 2008, 118: 2583-2591. PMID: 18568078, PMCID: PMC2430499, DOI: 10.1172/jci35055.Peer-Reviewed Original ResearchConceptsMiddle frontal gyrusNeural activityFood cuesFrontal gyrusFood-related visual cuesWeight lossFood intakeWeight loss-induced changesVisual food cuesVisual food stimuliMiddle temporal gyrusRelative leptin deficiencyWeight-reduced stateDaily subcutaneous injectionsBody weight maintenanceCognitive controlFood stimuliTemporal gyrusVisual cuesLeptin deficiencyObese subjectsWeight maintenanceLingual gyrusClinical managementFunctional MRI
2007
Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters
Egner T, Etkin A, Gale S, Hirsch J. Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters. Cerebral Cortex 2007, 18: 1475-1484. PMID: 17940084, DOI: 10.1093/cercor/bhm179.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingConflict, PsychologicalEmotionsFemaleHumansMaleNerve NetNeural PathwaysPhotic StimulationConceptsTask-relevant stimuliEmotional distractersTask-irrelevant emotional stimuliAnterior cingulateSensory cortexTask-irrelevant stimuliLateral prefrontal cortexDorsal anterior cingulateFunctional magnetic resonanceRostral anterior cingulateCognitive controlConflict monitoringEmotional stimuliStimulus representationsAmygdalar responsesEmotional controlEnhanced processingResolve ConflictsEmotional conflictNeuroanatomical networksPrefrontal cortexDistractersResolution of conflictsBiasing mechanismHuman brainBrain Activity Associated With Stimulation Therapy of the Visual Borderzone in Hemianopic Stroke Patients
Marshall RS, Ferrera JJ, Barnes A, Xian Zhang, O'Brien KA, Chmayssani M, Hirsch J, Lazar RM. Brain Activity Associated With Stimulation Therapy of the Visual Borderzone in Hemianopic Stroke Patients. Neurorehabilitation And Neural Repair 2007, 22: 136-144. PMID: 17698955, DOI: 10.1177/1545968307305522.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdultAgedAttentionBrainBrain MappingCerebrovascular CirculationFemaleFunctional LateralityHemianopsiaHumansMagnetic Resonance ImagingMaleMiddle AgedNeuronal PlasticityPhotic StimulationPhysical Therapy ModalitiesStrokeTreatment OutcomeVisual PathwaysVisual PerceptionConceptsVisual restoration therapyRestoration therapyHemianopic patientsAnterior cingulateHemianopic stroke patientsHigher-order visual areasBilateral anterior cingulateBilateral basal gangliaHome-based treatment programDorsolateral frontal cortexBlood oxygen level-dependent activityBrain activityFunctional magnetic resonance imagingMagnetic resonance imagingBrain Activity AssociatedCondition interactionLevel-dependent activityStroke patientsBasal gangliaBrain injuryStimulation therapyFrontal cortexMiddle temporal regionsRepetitive stimulationVisual therapyNeural Dynamics of Rejection Sensitivity
Kross E, Egner T, Ochsner K, Hirsch J, Downey G. Neural Dynamics of Rejection Sensitivity. Journal Of Cognitive Neuroscience 2007, 19: 945-956. PMID: 17536965, DOI: 10.1162/jocn.2007.19.6.945.Peer-Reviewed Original ResearchConceptsRejection sensitivityCognitive controlRS individualsDorsal frontal regionsFunctional magnetic resonanceThemes of rejectionRejection stimuliAffective stimuliEmotional appraisalEmotional processingNegative valenceIndividual differencesPrefrontal structuresNeural dynamicsDistress ratingsFrontal regionsRepresentational paintingsBrain regionsR participantsStimuliPositive imageDifferential recruitmentIndividual responsesParticipantsInterest level
2006
A Neural Representation of Categorization Uncertainty in the Human Brain
Grinband J, Hirsch J, Ferrera VP. A Neural Representation of Categorization Uncertainty in the Human Brain. Neuron 2006, 49: 757-763. PMID: 16504950, DOI: 10.1016/j.neuron.2006.01.032.Peer-Reviewed Original ResearchConceptsCategorization uncertaintyEvent-related functional MRIFundamental cognitive functionFrontoparietal attention networkMedial frontal gyrusStimulus categorizationNeural representationParietal eye fieldsVisual objectsCategorical boundariesAnterior insulaFrontal gyrusCortical substratesAttention networkCognitive functionVentral striatumFunctional MRIPsychophysical functionsEye fieldBrain regionsHuman brainDorsomedial thalamusDiscrete categoriesInsulaThalamic network
2005
Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information
Egner T, Hirsch J. Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information. Nature Neuroscience 2005, 8: 1784-1790. PMID: 16286928, DOI: 10.1038/nn1594.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBehaviorBrain MappingCerebral CortexCerebrovascular CirculationCognitionConflict, PsychologicalDecision MakingFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysNeuropsychological TestsPattern Recognition, VisualPhotic StimulationPrefrontal CortexReaction TimeVisual CortexVolitionConceptsTask-relevant informationCognitive control mechanismsTask-irrelevant informationCognitive controlTask-relevant stimulus informationCognitive control systemConflict resolutionDorsolateral prefrontal cortexHuman visual cortexAttentional biasingFace processingPerceptual processingFace stimuliStroop taskNeural representationStimulus informationResponse tendenciesOccurrence of conflictsHigh conflictPrefrontal cortexProminent modelsCortical responsesTrial levelCortical amplificationVisual cortexWhere Memory Meets Attention: Neural Substrates of Negative Priming
Egner T, Hirsch J. Where Memory Meets Attention: Neural Substrates of Negative Priming. Journal Of Cognitive Neuroscience 2005, 17: 1774-1784. PMID: 16269113, DOI: 10.1162/089892905774589226.Peer-Reviewed Original ResearchConceptsEpisodic retrievalNegative primingStimulus featuresColor-naming Stroop taskRight dorsolateral prefrontal cortexEpisodic memory retrievalSelective attention performanceMemory retrieval functionsEvent-related fMRICurrent target stimulusSelective attention systemNegative priming effectDorsolateral prefrontal cortexStroop taskAttention systemDistractor stimuliMemory retrievalAttention performanceNeurophysiological predictionsTarget stimuliStimulus informationNeural substratesNeural responsesTheoretical accountsPriming effect