2011
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder
Schneier FR, Pomplun M, Sy M, Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research 2011, 194: 271-278. PMID: 22047726, PMCID: PMC3230304, DOI: 10.1016/j.pscychresns.2011.08.006.Peer-Reviewed Original ResearchConceptsParoxetine treatmentInferior parietal lobuleGeneralized social anxiety disorderNeural responsesPosterior cingulateParietal lobuleAnxiety disordersGSAD patientsEye contactMiddle occipital cortexMiddle frontal gyrusFunctional magnetic resonanceSymptomatic improvementHealthy comparison participantsOccipital cortexSocial anxiety disorderSymptom reductionAnterior cingulatePatientsUnmedicated adultsParahippocampal cortexNeural circuitrySupramarginal gyrusFrontal gyrusCingulateDistinct but overlapping neural networks subserve depression and insecure attachment
Galynker II, Yaseen ZS, Katz C, Zhang X, Jennings-Donovan G, Dashnaw S, Hirsch J, Mayberg H, Cohen LJ, Winston A. Distinct but overlapping neural networks subserve depression and insecure attachment. Social Cognitive And Affective Neuroscience 2011, 7: 896-908. PMID: 22037687, PMCID: PMC3501706, DOI: 10.1093/scan/nsr074.Peer-Reviewed Original ResearchConceptsSub-cortical activityBeck Depression InventoryEffect of depressionLevel-dependent responsesSub-cortical componentsCortico-striatoCortical effectsDepression scoresThalamic circuitsDepression InventoryCortical encodingDepressionFMRI scanningBrain activityNeural mechanismsPsychotherapeutic outcomeInsecure attachmentScoresSame circuitryFemale strangerMultiple linear regressionLater attachmentLinear regressionPatientsAttachment insecurityBrain tissue volume changes following weight gain in adults with anorexia nervosa
Roberto CA, Mayer LE, Brickman AM, Barnes A, Muraskin J, Yeung L, Steffener J, Sy M, Hirsch J, Stern Y, Walsh BT. Brain tissue volume changes following weight gain in adults with anorexia nervosa. International Journal Of Eating Disorders 2011, 44: 406-411. PMID: 21661001, PMCID: PMC3816503, DOI: 10.1002/eat.20840.Peer-Reviewed Original ResearchConceptsShort-term weight restorationWeight restorationGray matterAnorexia nervosaCerebrospinal fluidWhite matterBrain tissue volume changesWM volumeBrain volume deficitsUnderweight patientsAdult patientsControl womenTissue volume changesBrain volumeVolume deficitsPatientsAdult womenWeight gainSignificant increaseNervosaBody massWomenDeficitsLow levelsRestoration
2010
Analysis of clamping versus cutting of T3 sympathetic nerve for severe palmar hyperhidrosis
Yanagihara TK, Ibrahimiye A, Harris C, Hirsch J, Gorenstein LA. Analysis of clamping versus cutting of T3 sympathetic nerve for severe palmar hyperhidrosis. Journal Of Thoracic And Cardiovascular Surgery 2010, 140: 984-989. PMID: 20951250, PMCID: PMC2964926, DOI: 10.1016/j.jtcvs.2010.08.014.Peer-Reviewed Original ResearchConceptsEndoscopic thoracic sympathectomyPalmar hyperhidrosisSympathetic chainQuality of lifeThoracic sympathectomySevere palmar hyperhidrosisT3 sympathectomySympathetic nervesChief complaintPatient satisfactionExcessive sweatingPatientsSympathectomyT3 levelsHyperhidrosisSymptomsHigh rateSeverityClamping techniqueClampingNerveSurgerySweatingThighComplaintsA network approach to assessing cognition in disorders of consciousness(e–Pub ahead of print)(CME)
Rodriguez Moreno D, Schiff N, Giacino J, Kalmar K, Hirsch J. A network approach to assessing cognition in disorders of consciousness(e–Pub ahead of print)(CME). Neurology 2010, 75: 1871-1878. PMID: 20980667, PMCID: PMC2995384, DOI: 10.1212/wnl.0b013e3181feb259.Peer-Reviewed Original ResearchMeSH KeywordsAdultAwarenessBrainCognitionConsciousness DisordersFemaleGlasgow Coma ScaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPattern Recognition, VisualPersistent Vegetative StatePoint-of-Care SystemsQuadriplegiaSensitivity and SpecificityVerbal BehaviorYoung AdultConceptsDisorders of consciousnessVegetative stateComa Recovery ScaleHigh-level cognitionObject-naming taskPicture-naming taskLanguage-related regionsElicit brain activationEMCS patientsVS patientsHealthy subjectsDiagnostic criteriaPatientsVolitional processesRecovery ScaleBrain activationLanguage networkFMRI studyMotor responseOvert behaviorConscious stateNeural systemsBehavioral assessmentCognitionPartial preservation
2009
Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa
Mayer L, Klein DA, Black E, Attia E, Shen W, Mao X, Shungu DC, Punyanita M, Gallagher D, Wang J, Heymsfield SB, Hirsch J, Ginsberg HN, Walsh BT. Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa. American Journal Of Clinical Nutrition 2009, 90: 1132-1137. PMID: 19793856, PMCID: PMC2762154, DOI: 10.3945/ajcn.2009.27820.Peer-Reviewed Original ResearchConceptsAdipose tissue distributionAcute weight restorationControl subjectsWeight maintenanceWeight restorationAdipose tissueAnorexia nervosaTissue distributionControl womenVisceral adipose tissue distributionLong-term weight maintenanceAdult womenWhole-body magnetic resonanceHealthy control subjectsFemale control subjectsHealthy control womenIntermuscular adipose tissueCentral adiposity phenotypeHospital dischargeNormal weightBody compositionNormalization of weightBody image distortionPatientsTime points11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls
Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE. 11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls. Journal Of Nuclear Medicine 2009, 50: 382-389. PMID: 19223416, PMCID: PMC3629294, DOI: 10.2967/jnumed.108.054866.Peer-Reviewed Original ResearchConceptsBeta-cell massType 1 diabetesInsulin secretionVMAT2 bindingRenal cortexLong-Standing Type 1 DiabetesType 2 vesicular monoamine transporterFunctional binding capacityBinding capacityVesicular monoamine transporterInsulin secretion measurementsHealthy controlsHigh nonspecific bindingHealthy subjectsPatientsPreclinical experimentsControl valuesHuman pancreasDiabetesPancreasSecretion measurementsMonoamine transportersReference tissueCortexVMAT2Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold?
Giacino JT, Schnakers C, Rodriguez-Moreno D, Kalmar K, Schiff N, Hirsch J. Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold? Progress In Brain Research 2009, 177: 33-48. PMID: 19818893, DOI: 10.1016/s0079-6123(09)17704-x.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMedication side effectsSevere brain injuryAssessment of patientsBehavioral assessmentCurrent diagnostic criteriaFunctional neuroimaging findingsBrain injuryInvoluntary movementsNeuroimaging findingsMotor impairmentDiagnostic criteriaSide effectsBehavioral assessment techniquesNeurophysiologic markersVegetative stateConscious stateGold standardBehavioral assessment methodsFunctional neuroimagingPatientsDisordersIndirect evidenceBehavioral markersMarkers
2006
Functional Neuroimaging Applications for Assessment and Rehabilitation Planning in Patients With Disorders of Consciousness
Giacino JT, Hirsch J, Schiff N, Laureys S. Functional Neuroimaging Applications for Assessment and Rehabilitation Planning in Patients With Disorders of Consciousness. Archives Of Physical Medicine And Rehabilitation 2006, 87: 67-76. PMID: 17140882, DOI: 10.1016/j.apmr.2006.07.272.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessHigher-order association corticesStudy of patientsRestoration of functionPrimary cortical areasFunctional magnetic resonanceFunctional neuroimaging techniquesFunctional neuroimaging protocolsPotential clinical applicationsPathophysiologic mechanismsPattern of activationPatient characterizationPositron emission tomography activation studyDifferential diagnosisPrognostic assessmentDisconnection syndromeCortical areasAssociation cortexLarge-scale cortical networksPatientsNeuroimaging protocolVegetative stateNeuroimaging techniquesConscious stateCortical networksCortical reorganization following intradigital tendon transfer
Viswanathan V, Chmayssani M, Adams DJ, Hirsch J. Cortical reorganization following intradigital tendon transfer. Neuroreport 2006, 17: 1669-1673. PMID: 17047451, DOI: 10.1097/01.wnr.0000239953.60695.08.Peer-Reviewed Original ResearchFacial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis
McClelland S, Garcia RE, Peraza DM, Shih TT, Hirsch LJ, Hirsch J, Goodman RR. Facial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis. Epilepsia 2006, 47: 1337-1342. PMID: 16922878, DOI: 10.1111/j.1528-1167.2006.00557.x.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisAnteromedial temporal lobectomyTemporal lobe epilepsyTLE onsetTemporal sclerosisTemporal lobectomyRight amygdalaEarly-onset patientsLate-onset patientsEarly-onset groupLate-onset groupAmygdalar damageAge 6 yearsFER impairmentPostsurgical populationLobe epilepsyLeft-hemisphere language dominancePreoperative MRIPatientsFrightened expressionImpaired facial emotion recognitionLobectomySclerosisAmygdalaOnsetStructure-function relationships in the human visual system using DTI, fMRI and visual field testing: pre- and post-operative assessments in patients with anterior visual pathway compression.
Rosiene J, Liu X, Imielinska C, Ferrera J, Bruce J, Hirsch J, D'Ambrosio A. Structure-function relationships in the human visual system using DTI, fMRI and visual field testing: pre- and post-operative assessments in patients with anterior visual pathway compression. 2006, 119: 464-6. PMID: 16404100.Peer-Reviewed Original ResearchConceptsAnterior visual pathway compressionVisual pathway compressionDiffusion tensor imagingFunctional MRIVisual lossVisual recoveryFunctional visual deficitsLarge pituitary lesionsPostoperative visual recoveryProgressive visual lossSignificant visual lossVisual field testingPost-operative assessmentWhite matter projectionsDTI dataVisual field mappingSurgical resectionOptic chiasmPituitary lesionsOptic radiationVisual deficitsFunctional visionPatientsBrain structuresTensor imaging
2004
Hypoperfusion without stroke alters motor activation in the opposite hemisphere
Krakauer JW, Radoeva PD, Zarahn E, Wydra J, Lazar RM, Hirsch J, Marshall RS. Hypoperfusion without stroke alters motor activation in the opposite hemisphere. Annals Of Neurology 2004, 56: 796-802. PMID: 15562431, DOI: 10.1002/ana.20286.Peer-Reviewed Original ResearchConceptsIpsilateral activationMiddle cerebral artery diseaseCerebral artery diseaseLarge vessel diseaseAge-matched controlsMotor-related areasNormal motor performanceFunctional magnetic resonanceHemodynamic compromiseVasomotor reactivityArtery diseaseHemispheric hypoperfusionCortical reorganizationInternal carotidHand contralateralPatientsMotor activationMotor tasksMotor performanceHypoperfusionHemispheric activationUnique activationDiseaseActivationMagnetic resonance
2000
Visual Function and Brain Organization in Non-decussating Retinal–Fugal Fibre Syndrome
Victor J, Apkarian P, Hirsch J, Conte M, Packard M, Relkin N, Kim K, Shapley R. Visual Function and Brain Organization in Non-decussating Retinal–Fugal Fibre Syndrome. Cerebral Cortex 2000, 10: 2-22. PMID: 10639391, DOI: 10.1093/cercor/10.1.2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrain MappingContrast SensitivityElectroencephalographyFemaleFunctional LateralityHumansInfantMagnetic Resonance ImagingMotion PerceptionNeuronal PlasticityOptic ChiasmOptic Nerve DiseasesPhotic StimulationRetinaSyndromeTwins, DizygoticVisual CortexVisual PathwaysVisual PerceptionConceptsVisual functionIpsilateral primary visual cortexExtensive bilateral activationMagnetic resonance imaging studyNormal visual behaviorPrimary visual cortexResonance imaging studyFunctional magnetic resonance imaging studyPrestriate areasVisual namingOcular instabilityRetinal projectionsStriate cortexBilateral activationVisual cortexVisual pathwayImaging studiesContrast sensitivityContralateral representationElectrophysiological investigationsEye mapSimple visual stimuliFunctional neuroimagingPatientsBrain organization
1999
Concordance between Functional Magnetic Resonance Imaging and Intraoperative Language Mapping
Ruge M, Victor J, Hosain S, Correa D, Relkin N, Tabar V, Brennan C, Gutin P, Hirsch J. Concordance between Functional Magnetic Resonance Imaging and Intraoperative Language Mapping. Stereotactic And Functional Neurosurgery 1999, 72: 95-102. PMID: 10853058, DOI: 10.1159/000029706.Peer-Reviewed Original ResearchConceptsDirect cortical stimulationIntraoperative electrophysiologyCortical stimulationSensorimotor cortexIntraoperative language mappingFunctional magnetic resonance imagingMagnetic resonance imagingSSEP recordingsLocalization of functionMotor cortexIntraoperative localizationPreoperative toolResonance imagingLanguage mappingCortexWernicke's areaElectrophysiologyFMRIPresent studyStimulationSensorimotor mappingConcordancePatientsBroca
1991
Assessment of potential contrast sensitivity Part 1: Preoperative prediction of contrast sensitivity following intraocular lens implantation
Morris M, Klett Z, Gieser S, Couch J, Hirsch J. Assessment of potential contrast sensitivity Part 1: Preoperative prediction of contrast sensitivity following intraocular lens implantation. Journal Of Cataract & Refractive Surgery 1991, 17: 37-44. PMID: 2005557, DOI: 10.1016/s0886-3350(13)80982-0.Peer-Reviewed Original ResearchConceptsPostoperative contrast sensitivity functionPreoperative visual acuityContrast sensitivity functionPreoperative visual acuity of 20/200Contrast sensitivityMild to moderate cataractsVisual acuity of 20/200Postoperative contrast sensitivityAcuity of 20/200Intraocular lens implantationModerate cataractLens implantationVisual acuityCataract patientsLens opacitiesPostoperative complicationsPreoperative measurementsPreoperative predictionCataractPatientsEyesAcuityComplicationsAssessment of contrast sensitivity Part II: The relationship between objective lens opacity and laser interferometric contrast sensitivity in the cataract patient
Klett Z, Morris M, Gieser S, Couch J, Hirsch J. Assessment of contrast sensitivity Part II: The relationship between objective lens opacity and laser interferometric contrast sensitivity in the cataract patient. Journal Of Cataract & Refractive Surgery 1991, 17: 45-57. PMID: 2005558, DOI: 10.1016/s0886-3350(13)80983-2.Peer-Reviewed Original ResearchConceptsLens opacitiesContrast sensitivityRetinal functionLaser interferometric measurementMeasure retinal functionPreoperative lens opacitiesRetinal contrast sensitivityOpacity lensmeterCataract densityCataract populationCataract patientsCataract typeImmature cataractCataractPatientsInverse linear relationshipOpacitySensitivityLensmeterCorrelation coefficient
1988
Assessment of retinal function in cataract patients by a combination of laser interferometry and conventional display methods to measure contrast sensitivity.
Jankelovits E, Lichtenstein S, Groll S, Remijan P, Hirsch J. Assessment of retinal function in cataract patients by a combination of laser interferometry and conventional display methods to measure contrast sensitivity. Applied Optics 1988, 27: 1057-63. PMID: 20531519, DOI: 10.1364/ao.27.001057.Peer-Reviewed Original ResearchMeasure retinal functionRetinal functionCompare contrast sensitivity functionLoss of visual functionMeasures of retinal functionAssessment of retinal functionMeasuring contrast sensitivityCataract patientsNormal eyesVisual functionCataractContrast sensitivityContrast sensitivity functionEye's opticsEyesContrast thresholdsConventional display methodContrast transfer functionLaser interferometryPatientsEvaluation of Corrected Loss Variance as a Visual Field Index
Liao P, Gollamudi S, Hirsch J. Evaluation of Corrected Loss Variance as a Visual Field Index. Ophthalmologica 1988, 197: 136-143. PMID: 3231420, DOI: 10.1159/000309934.Peer-Reviewed Original ResearchConceptsCorrected loss varianceVisual field indicesLoss varianceField indicesClinical diagnosis of glaucomaDiagnosed glaucoma patientsGlaucoma suspect groupGlaucoma-suspect patientsOctopus visual fieldDiagnosis of glaucomaGroup of patientsVisual fieldGlaucoma groupGlaucoma patientsField lossStudy groupPatientsClinical diagnosisControl groupGlaucomaGroup