2014
Negative Blood Oxygen Level Dependent Signals During Speech Comprehension
Moreno D, Schiff ND, Hirsch J. Negative Blood Oxygen Level Dependent Signals During Speech Comprehension. Brain Connectivity 2014, 5: 232-244. PMID: 25412406, PMCID: PMC4432885, DOI: 10.1089/brain.2014.0272.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependent (BOLD) signalSpeech conditionsLevel-dependent signalBOLD signalSpeech comprehensionResting baselineNatural speechComprehension of speechCanonical language areasLanguage-related tasksNatural speech conditionNegative BOLD responseReceptive languageLanguage tasksPassive listeningComprehension studiesFrontoparietal regionsLanguage areasSame stimuliBOLD responseComprehensionBrain regionsSame speech
2009
Reperfusion normalizes motor activation patterns in large‐vessel disease
Chmayssani M, Lazar RM, Hirsch J, Marshall RS. Reperfusion normalizes motor activation patterns in large‐vessel disease. Annals Of Neurology 2009, 65: 203-208. PMID: 19259970, PMCID: PMC2653600, DOI: 10.1002/ana.21554.Peer-Reviewed Original ResearchConceptsMotor activation patternsVasomotor reactivityActivation patternsInterest analysisIpsilateral motor activationLarge vessel diseaseNormal neurological functionHealthy control subjectsHigh-grade stenosisBlood oxygen level-dependent (BOLD) signalNormal blood flowDynamic functional reorganizationLevel-dependent signalFunctional magnetic resonanceRepeated-measures analysisHemodynamic failureHemodynamic impairmentRevascularization proceduresIpsilateral hemisphereNeurological functionControl subjectsClinical consequencesBlood flowFunctional reorganizationSpontaneous resolution
1999
Brain Mapping in Sedated Infants and Young Children with Passive-Functional Magnetic Resonance Imaging
Souweidane M, Kim K, McDowall R, Ruge M, Lis E, Krol G, Hirsch J. Brain Mapping in Sedated Infants and Young Children with Passive-Functional Magnetic Resonance Imaging. Pediatric Neurosurgery 1999, 30: 86-92. PMID: 10325564, DOI: 10.1159/000028768.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingSedated childrenResonance imagingBrain mappingDiagnostic MRI scanYoung childrenLevel-dependent signalEarly developmental statusPediatric patientsPatient complianceMRI scansSedated infantsCortical regionsPatient interactionsFMRI techniquesFrequent needFMRI procedureLanguage functionChildrenInfantsDevelopmental statusPassive stimuliImagingStandard techniques