Can Depression be Diagnosed by Response to Mother's Face? A Personalized Attachment-Based Paradigm for Diagnostic fMRI
Zhang X, Yaseen ZS, Galynker II, Hirsch J, Winston A. Can Depression be Diagnosed by Response to Mother's Face? A Personalized Attachment-Based Paradigm for Diagnostic fMRI. PLOS ONE 2011, 6: e27253. PMID: 22180777, PMCID: PMC3236742, DOI: 10.1371/journal.pone.0027253.Peer-Reviewed Original ResearchConceptsBDI-II scoresFunctional magnetic resonance imagingBeck Depression Inventory-IIMagnetic resonance imagingResonance imagingInventory-IIBeck Depression Inventory-II scoresMINI psychiatric interviewII scoreDepression diagnosisPsychiatric interviewBA 32Paracingulate gyrusDepressed subjectsActivity patternsClinical diagnosisBrain reactivitySensitivity 85.7Diagnostic algorithmFemale subjectsDepressionSpecificity 92.8FMRI imagingScoresBrain activityDistinct but overlapping neural networks subserve depression and insecure attachment
Galynker II, Yaseen ZS, Katz C, Zhang X, Jennings-Donovan G, Dashnaw S, Hirsch J, Mayberg H, Cohen LJ, Winston A. Distinct but overlapping neural networks subserve depression and insecure attachment. Social Cognitive And Affective Neuroscience 2011, 7: 896-908. PMID: 22037687, PMCID: PMC3501706, DOI: 10.1093/scan/nsr074.Peer-Reviewed Original ResearchConceptsSub-cortical activityBeck Depression InventoryEffect of depressionLevel-dependent responsesSub-cortical componentsCortico-striatoCortical effectsDepression scoresThalamic circuitsDepression InventoryCortical encodingDepressionFMRI scanningBrain activityNeural mechanismsPsychotherapeutic outcomeInsecure attachmentScoresSame circuitryFemale strangerMultiple linear regressionLater attachmentLinear regressionPatientsAttachment insecurity