2022
Imaging the effect of ketamine on synaptic density (SV2A) in the living brain
Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain. Molecular Psychiatry 2022, 27: 2273-2281. PMID: 35165397, PMCID: PMC9133063, DOI: 10.1038/s41380-022-01465-2.Peer-Reviewed Original ResearchConceptsKetamine's therapeutic effectsMajor depressive disorderTherapeutic effectPositron emission tomographyPosttraumatic stress disorderHealthy controlsSynaptic connectionsSynaptic vesicle protein 2APost-synaptic mechanismsEffects of ketamineDiscovery of ketamineNon-human primatesAntidepressant effectsDepressive disorderSingle administrationSynaptic densityPsychiatric disordersDepression severityKetamineEmission tomographyTerminal densityLiving brainStress disorderRobust reductionDissociative symptoms
2014
Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal
Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O’Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-18036. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.Peer-Reviewed Original ResearchConceptsGABAA receptor levelsAlcohol withdrawalTobacco smokingReceptor levelsGABAA receptorsAlcohol-dependent smokersGABAA receptor availabilityMo of abstinenceProlonged alcohol withdrawalGABAA receptor systemCombination of alcoholNicotine blocksComorbid alcoholSustained elevationAlcohol abstinenceNicotine dependenceRobust elevationReceptor availabilityNicotine consumptionSmokingReceptor systemFirst weekNonhuman primatesControl levelsWithdrawalEvaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys
Gallezot J, Esterlis I, Bois F, Zheng M, Lin S, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse 2014, 68: 556-564. PMID: 25043426, PMCID: PMC4224280, DOI: 10.1002/syn.21767.Peer-Reviewed Original ResearchConceptsSynaptic acetylcholine concentrationPositron emission tomographyAcetylcholine concentrationRhesus monkeysInfusion of physostigmineSynaptic acetylcholine levelsDose-dependent reductionNicotinic acetylcholine receptorsAcetylcholine levelsBolus injectionAcetylcholine receptorsAcetylcholine dynamicsNew radioligandEmission tomographyArterial input functionAcetylcholinesterase inhibitorsRadioligandThalamusPhysostigmineDonepezilΑ4β2Promising tracerBaselineMonkeysShort scan duration
2010
Decreased Beta2*‐nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates
Cosgrove KP, Kloczynski T, Bois F, Pittman B, Tamagnan G, Seibyl JP, Krystal JH, Staley JK. Decreased Beta2*‐nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates. Synapse 2010, 64: 729-732. PMID: 20340174, PMCID: PMC2904861, DOI: 10.1002/syn.20795.Peer-Reviewed Original ResearchConceptsChronic ethanol consumptionEthanol consumptionAlcohol consumptionNicotinic acetylcholine receptor availabilityAverage daily ethanol consumptionChronic ethanol exposureDaily ethanol consumptionEthanol-induced changesNicotinic acetylcholine receptorsSelf-administer ethanolIA-85380H withdrawalEthanol exposureReceptor availabilityAcetylcholine receptorsParietal cortexMale animalsTotal gramsBaselinePercent decreasePersistent changesWithdrawalMidbrainCortexAnimals
1989
Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys
Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.Peer-Reviewed Original ResearchConceptsOpiate withdrawal syndromeInjection of naloxoneWithdrawal syndromeTreatment periodNaloxone injectionNaloxone administrationWithdrawal responsePhysical dependenceDays of methadoneAntagonist exposureMethadone treatmentDaily injectionsLack of incrementReceptor mechanismsDrug combinationsNaloxoneRhesus monkeysSyndromeDay 16MethadoneSame monkeysManagement of situationsInjectionAdministrationDaysThe effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey
Krystal J, Woods S, Levesque M, Heninger C, Heninger G. The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey. Life Sciences 1989, 45: 1657-1663. PMID: 2511388, DOI: 10.1016/0024-3205(89)90275-0.Peer-Reviewed Original ResearchConceptsGrowth hormonePlasma MHPGChair-adapted rhesus monkeysRespiratory rateRhesus monkeysSignificant dose-dependent increaseEffects of inhalationDose-dependent increaseCarbon dioxide inhalationNorepinephrine metabolitePlasma levelsPlasma hormonesMHPGBehavioral activationInhalationHormoneProlactinShort durationCortisolMonkeysMinutesPeak changes