1992
Noradrenergic neuronal dysregulation in panic disorder: the effects of intravenous yohimbine and clonidine in panic disorder patients
Charney DS, Woods SW, Krystal JH, Nagy LM, Heninger GR. Noradrenergic neuronal dysregulation in panic disorder: the effects of intravenous yohimbine and clonidine in panic disorder patients. Acta Psychiatrica Scandinavica 1992, 86: 273-282. PMID: 1333719, DOI: 10.1111/j.1600-0447.1992.tb03266.x.Peer-Reviewed Original ResearchConceptsPanic disorder patientsDisorder patientsPanic disorderIntravenous yohimbineHealthy subjectsYohimbine-induced panic attacksClonidine-induced decreaseYohimbine-induced increasesGrowth hormone responseNeuronal dysregulationCardiovascular effectsPlasma MHPGPatientsPlasma 3Hormone responseNeuronal functionPanic attacksClonidineHuman dataDisordersYohimbineHuman anxietySubgroupsFear statesFunctional regulation
1989
Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects
Woods S, Krystal J, Heninger G, Charney D. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. Life Sciences 1989, 45: 233-242. PMID: 2503670, DOI: 10.1016/0024-3205(89)90255-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlprazolamAnxietyCarbon DioxideClonidineFemaleHumansMalePulseReference ValuesTidal VolumeConceptsHealthy human subjectsClonidine 2 mcg/Pulse rateEffects of alprazolamAnxiety-like effectsHuman subjectsRatings of anxietyOral alprazolamHypotensive effectVentilatory responseMcg/Noradrenergic systemBenzodiazepine receptorsAnxiolytic propertiesNeurobiologic mechanismsClonidineNew drugsAlprazolamAnxiety ratingsSubjective anxietyDrugsAnxietyNormal functioningNeural systemsUseful model system
1984
Multiple Mechanisms of withdrawal from Opioid Drugs
Redmond DE, Krystal JH. Multiple Mechanisms of withdrawal from Opioid Drugs. Annual Review Of Neuroscience 1984, 7: 443-478. PMID: 6324646, DOI: 10.1146/annurev.ne.07.030184.002303.Peer-Reviewed Original ResearchAcetylcholineAdenine NucleotidesAnimalsBenzodiazepinesCalciumCalmodulinClonidineConditioning, PsychologicalCyclic GMPDopamineDrug ToleranceEnkephalinsFearGamma-Aminobutyric AcidHumansMethadoneNaloxoneNarcotic AntagonistsNarcoticsNeuronsNorepinephrineProtein ConformationReceptors, OpioidSerotoninSubstance Withdrawal Syndrome