2021
Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans
Na PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.Peer-Reviewed Original ResearchConceptsNew-onset suicidal ideationChronic suicidal ideationPolygenic risk scoresSuicidal ideationProspective cohort studyPolygenic riskRisk of SIHigher baseline levelsHigh polygenic riskModifiable psychosocial factorsSocial supportDispositional optimismCohort studyProspective cohortUS veteransSymptomatic courseRisk scorePsychosocial factorsGenome-wide association studiesBaseline levelsU.S. veteransSuicidal thoughtsPsychosocial moderatorsStudy periodLarge genome-wide association studiesPrevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic
Nichter B, Hill ML, Na PJ, Kline AC, Norman SB, Krystal JH, Southwick SM, Pietrzak RH. Prevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2021, 78: 1218-1227. PMID: 34431973, PMCID: PMC8387942, DOI: 10.1001/jamapsychiatry.2021.2332.Peer-Reviewed Original ResearchConceptsUS military veteransCOVID-19 infectionCohort studySuicidal behaviorPast-year suicide ideationRisk factorsMilitary veteransPopulation-based prospective cohort studyCOVID-19 pandemicSuicide ideationSuicide attemptsProspective cohort studyLifetime posttraumatic stress disorderStrong risk factorCOVID-19 public health emergencyLow social supportPosttraumatic stress disorderPublic health emergencyAlcohol use disorder severityUS veteransNational HealthMAIN OUTCOMESuicide attempt historyVeterans StudyCOVID-19-related variablesMental health impact of the COVID-19 pandemic in U.S. military veterans: a population-based, prospective cohort study
Hill ML, Nichter B, Na PJ, Norman SB, Morland LA, Krystal JH, Pietrzak RH. Mental health impact of the COVID-19 pandemic in U.S. military veterans: a population-based, prospective cohort study. Psychological Medicine 2021, 53: 945-956. PMID: 34120667, PMCID: PMC8245339, DOI: 10.1017/s0033291721002361.Peer-Reviewed Original ResearchConceptsPositive screenPsychiatric distressU.S. military veteran populationMiddle-aged veteransProspective cohort studyProspective cohort surveyMajor depressive disorderMilitary veteran populationMental health problemsMental health impactU.S. military veteransCohort studyDepressive disorderNational HealthPsychiatric symptomsVeteran populationCohort surveyHealth problemsU.S. veteransVeterans StudyClinical implicationsCoronavirus diseaseProtective factorsMeaningful preMental health
2019
Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study
Mota NP, Cook JM, Smith NB, Tsai J, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study. Journal Of Psychiatric Research 2019, 119: 23-31. PMID: 31546045, DOI: 10.1016/j.jpsychires.2019.09.005.Peer-Reviewed Original ResearchConceptsPTSD symptom courseSymptom courseU.S. military veteransLatent growth mixture modelingProspective cohort studyMilitary veteransLifetime psychiatric historyMental health treatmentPhysical health difficultiesLifetime traumatic eventsTrauma-exposed veteransProtective psychosocial characteristicsCohort studyProspective cohortModerate symptomsModifiable correlatesNational HealthSymptomatic coursePsychiatric historyHealth treatmentU.S. veteransVeterans StudyPsychosocial characteristicsHigher symptomsHealth difficulties
2016
Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study
Isaacs K, Mota NP, Tsai J, Harpaz-Rotem I, Cook JM, Kirwin PD, Krystal JH, Southwick SM, Pietrzak RH. Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study. Journal Of Psychiatric Research 2016, 84: 301-309. PMID: 27814502, DOI: 10.1016/j.jpsychires.2016.10.017.Peer-Reviewed Original ResearchConceptsU.S. military veteransTrauma-exposed veteransPsychological resilienceTrauma exposureMilitary veteransResilient groupTrauma-related psychological symptomsDistressed groupHigh trauma exposureCurrent psychological distressLifetime trauma exposurePhysical health difficultiesSense of purposeProspective cohort studyDispositional gratitudePosttraumatic stressTraumatic eventsEmotional stabilityPsychological distressCurrent distressLifetime traumaAnxiety disordersDistress symptomsHealth difficultiesPsychological symptomsThe burden of hostility in U.S. Veterans: Results from the National Health and Resilience in Veterans Study
Sippel LM, Mota NP, Kachadourian LK, Krystal JH, Southwick SM, Harpaz-Rotem I, Pietrzak RH. The burden of hostility in U.S. Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry Research 2016, 243: 421-430. PMID: 27450745, DOI: 10.1016/j.psychres.2016.06.040.Peer-Reviewed Original ResearchConceptsS. veteransLongitudinal courseNational HealthProtective correlatesVeterans StudyProspective cohort studyPopulation-based evaluationPopulation-based dataAggressive urgesMajority of veteransPhysical health consequencesProtective psychosocial characteristicsCohort studySymptomatic courseAlcohol misuseU.S. veteransPsychosocial characteristicsHealth consequencesTreatment effortsPsychological distressVeteransTwo-year periodPrevalenceRiskSocial connectedness
2012
Mild Worry Symptoms Predict Decline in Learning and Memory in Healthy Older Adults: A 2-Year Prospective Cohort Study
Pietrzak RH, Maruff P, Woodward M, Fredrickson J, Fredrickson A, Krystal JH, Southwick SM, Darby D. Mild Worry Symptoms Predict Decline in Learning and Memory in Healthy Older Adults: A 2-Year Prospective Cohort Study. American Journal Of Geriatric Psychiatry 2012, 20: 266-275. PMID: 22354117, PMCID: PMC3285262, DOI: 10.1097/jgp.0b013e3182107e24.Peer-Reviewed Original ResearchConceptsWorry symptomsOlder adultsCommunity-dwelling older adultsCognitive functionAge-related cognitive changesHealthy Older AdultsImportance of anxietyEarly cognitive declineDepressive symptomsAssociate learningCognitive agingVisual learningCognitive changesProspective cohort studyCognitive declineDepression symptomsEarly dementiaCohort studyObservational prospective cohort studyMemoryMild levelsLearningWorryAdultsTheoretical model
2010
A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship
Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship. JAMA Psychiatry 2010, 67: 557-565. PMID: 20368500, PMCID: PMC4036806, DOI: 10.1001/archgenpsychiatry.2010.41.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesDepressionDepressive DisorderDepressive Disorder, MajorFemaleGenotypeHealth StatusHumansInternship and ResidencyLife Change EventsMaleMedicinePolymorphism, Single NucleotidePrevalenceProspective StudiesRisk FactorsSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalStudents, MedicalSurveys and QuestionnairesConceptsDepressive symptomsPHQ-9 depression scoresProspective cohort studyPrevalence of depressionPatient Health QuestionnaireProportion of participantsMedical internsMedical internshipGreater increasePHQ-9 criteriaCohort studyHealth QuestionnaireMood symptomsGeneral populationDepression scoresUS hospitalsSymptomsSerotonin transporter protein geneGenetic polymorphismsDepressionGenetic factorsLife stressMarked increaseRecent reportsResidency programs