2022
Post-traumatic Stress Disorder
Merians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderStress disorderCognitive processing therapyCognitive behavioral therapyEye movement desensitizationEvidence-based psychotherapiesTraumatic eventsBehavioral therapyNegative alterationsFirst-line pharmacologic treatmentStructured interviewsFirst-line treatmentNonpsychiatric settingsLarge bodyPharmacologic treatmentReuptake inhibitorsCognitionDisordersArousalTherapeutic interventionsMoodPsychotherapyAvoidanceTherapyInterventionTechnology and Mental Health: State of the Art for Assessment and Treatment
Harvey PD, Depp CA, Rizzo AA, Strauss GP, Spelber D, Carpenter LL, Kalin NH, Krystal JH, McDonald WM, Nemeroff CB, Rodriguez CI, Widge AS, Torous J. Technology and Mental Health: State of the Art for Assessment and Treatment. American Journal Of Psychiatry 2022, 179: 897-914. PMID: 36200275, DOI: 10.1176/appi.ajp.21121254.Peer-Reviewed Original ResearchConceptsHigh-quality evidenceEcological momentary assessmentTechnology-based interventionsMental health applicationsClinical trialsTreatment strategiesCognitive trainingFunctional capacityDrug AdministrationSystematic reviewVirtual reality approachMomentary assessmentU.S. FoodMental healthFunctional skillsTechnology-based assessmentInterventionTechnology-based approachesTreatmentAssessmentHealth applicationsPhysiological parametersReality approachReviewEmotionsThe Stress and Resilience Town Hall: A systems response to support the health workforce during COVID-19 and beyond
Tebes JK, Awad MN, Connors EH, Fineberg SK, Gordon DM, Jordan A, Kravitz R, Li L, Ponce AN, Prabhu M, Rubman S, Silva MA, Steinfeld M, Tate DC, Xu K, Krystal JH. The Stress and Resilience Town Hall: A systems response to support the health workforce during COVID-19 and beyond. General Hospital Psychiatry 2022, 77: 80-87. PMID: 35569322, PMCID: PMC9033303, DOI: 10.1016/j.genhosppsych.2022.04.009.Peer-Reviewed Original ResearchConceptsHealthcare workersHealth systemHealth workforceCOVID-19 pandemicHealth workforce needsMean attendancePost-traumatic stressCOVID-19Traumatic stressorsTypes of stressorsSustainable interventionsRigorous qualitative methodsInterventionPandemicSpecific stressorsStressorsWorkforce needsHospitalWorkers
2017
Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS?
Taylor JJ, Krystal JH, D'Souza DC, Gerrard JL, Corlett PR. Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS? Schizophrenia Research 2017, 195: 455-462. PMID: 28969932, PMCID: PMC8141945, DOI: 10.1016/j.schres.2017.09.020.Peer-Reviewed Original ResearchConceptsDeep brain stimulationTranscranial magnetic stimulationAuditory hallucinationsBrain stimulationCombination of TMSTreatment-refractory schizophreniaAberrant neural networksRelevant neural networksNon-invasive formNeuromodulatory interventionsMagnetic stimulationPsychiatric disordersSymptom clusteringTherapeutic interventionsClinical decisionInvasive formNeurophysiological dataCausal evidencePsychiatric constructsStimulationNetwork modulationInterventionNeural networkSafety concernsInvestigational probes
2016
Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study
Gerin MI, Fichtenholtz H, Roy A, Walsh CJ, Krystal JH, Southwick S, Hampson M. Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study. Frontiers In Psychiatry 2016, 7: 111. PMID: 27445868, PMCID: PMC4914513, DOI: 10.3389/fpsyt.2016.00111.Peer-Reviewed Original ResearchPost-traumatic stress disorderChronic post-traumatic stress disorderResting-state functional connectivity patternsReal-time functional magnetic resonanceStudy of efficacyReal-time fMRI neurofeedbackWar veteransFunctional connectivity patternsFunctional magnetic resonanceClinical improvementAvailable treatmentsTrauma scriptsSymptom reductionMeaningful improvementsNovel interventionsNF trainingStress disorderBrain connectivityNeurofeedback interventionAmygdala activityFMRI neurofeedbackCombat veteransInterventionVeteransFeasibility study
2008
Practitioner Review: Adolescent alcohol use disorders: assessment and treatment issues
Perepletchikova F, Krystal JH, Kaufman J. Practitioner Review: Adolescent alcohol use disorders: assessment and treatment issues. Journal Of Child Psychology And Psychiatry 2008, 49: 1131-1154. PMID: 19017028, PMCID: PMC4113213, DOI: 10.1111/j.1469-7610.2008.01934.x.Peer-Reviewed Original ResearchConceptsAdolescent alcohol use disordersAlcohol use disorderUse disordersMultidimensional Family TherapyCognitive behavioral therapyBurgeoning of researchSubstance use disordersPaucity of researchBehavioral therapyTrauma experiencesFamily therapyEmpirical supportPharmacological interventionsClinical interventionsIntervention strategiesFirm treatment recommendationsAppropriate clinical interventionsTreatment issuesAdolescentsTranslational research approachDisordersNovel intervention strategiesRandomized studyInterventionSignificant morbidity
2005
Temporoparietal Transcranial Magnetic Stimulation for Auditory Hallucinations: Safety, Efficacy and Moderators in a Fifty Patient Sample
Hoffman RE, Gueorguieva R, Hawkins KA, Varanko M, Boutros NN, Wu YT, Carroll K, Krystal JH. Temporoparietal Transcranial Magnetic Stimulation for Auditory Hallucinations: Safety, Efficacy and Moderators in a Fifty Patient Sample. Biological Psychiatry 2005, 58: 97-104. PMID: 15936729, DOI: 10.1016/j.biopsych.2005.03.041.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationTranscranial magnetic stimulationAuditory hallucinationsSham stimulationMagnetic stimulationTemporoparietal repetitive transcranial magnetic stimulationClinical Global Impression ScaleGlobal Impression ScaleRight-handed patientsMotor thresholdImpression ScaleRTMS effectsNew patientsNeurocognitive impairmentHallucination frequencySchizoaffective disorderPatient samplesSignificant distressPatientsChange scoresHallucinationsPreliminary reportStimulationNeurobiological factorsIntervention
2003
Toward early pharmacological posttraumatic stress intervention
Morgan CA, Krystal JH, Southwick SM. Toward early pharmacological posttraumatic stress intervention. Biological Psychiatry 2003, 53: 834-843. PMID: 12725976, DOI: 10.1016/s0006-3223(03)00116-1.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderExtreme psychological traumaStress-related symptomsIntrusive memoriesPsychological processingExtreme arousalTrauma survivorsPsychological traumaStress disorderStress interventionsAcute aftermathExtreme stressPharmacologic interventionsAdaptive roleEffective pharmacologic interventionsPotential pharmacologic interventionsInterventionTransient symptomsImmediate aftermathArousalEmpirical dataEarly symptomsMemorySymptomsTrauma