2020
Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity
Preller KH, Duerler P, Burt JB, Ji JL, Adkinson B, Stämpfli P, Seifritz E, Repovš G, Krystal JH, Murray JD, Anticevic A, Vollenweider FX. Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity. Biological Psychiatry 2020, 88: 197-207. PMID: 32111343, DOI: 10.1016/j.biopsych.2019.12.027.Peer-Reviewed Original ResearchConceptsFunctional connectivityBaseline connectivityResting-state functional connectivityGlobal functional connectivityBrain-wide connectivityHealthy human participantsPersonalized medicine approachPeak effectUse of psilocybinMechanism of actionSerotonin 2ATime-dependent mannerCrossover studyPredictive markerPsychedelic treatmentMedicine approachReceptor systemSensory regionsClinical contextTime pointsAssociative regionsDifferent test daysAdministrationTest dayTime-dependent changes
2007
Psychiatric safety of ketamine in psychopharmacology research
Perry EB, Cramer JA, Cho HS, Petrakis IL, Karper LP, Genovese A, O’Donnell E, Krystal JH, D’Souza D. Psychiatric safety of ketamine in psychopharmacology research. Psychopharmacology 2007, 192: 253-260. PMID: 17458544, DOI: 10.1007/s00213-007-0706-2.Peer-Reviewed Original ResearchConceptsSubanesthetic dosesHealthy human subjectsKetamine administrationClinical research programHuman subjectsTest sessionsPsychotic spectrum disordersPsychiatric safetyResidual sequelaePlacebo infusionIntravenous infusionKetamine effectsPsychopharmacology studiesResultsFour hundredAdverse reactionsObjectiveTo reportHealthy subjectsStudy participationClinical investigationHealthy humansSide effectsKetamineInfusionDosesAdministration
1997
Lack of behavioral effects of monoamine depletion in healthy subjects
Salomon R, Miller H, Krystal J, Heninger G, Charney D. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry 1997, 41: 58-64. PMID: 8988796, DOI: 10.1016/0006-3223(95)00670-2.Peer-Reviewed Original ResearchConceptsAmino acid drinkHealthy subjectsAcid drinkTryptophan-free amino acid drinkBehavioral effectsTyrosine hydroxylase inhibitorTest sessionsMonoamine depletionMonoamine hypothesisPara-tyrosineCombined administrationAlpha-methylHydroxylase inhibitorDrinksSubjectsSessionsAMPTCatecholaminesAdministration
1994
ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERS
Karper L, Bennett A, Erdos J, Krystal J. ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERS. Journal Of Offender Rehabilitation 1994, 21: 203-222. DOI: 10.1300/j076v21n03_13.Peer-Reviewed Original ResearchPsychiatric patientsCombination of medicationsUse of antipsychoticsTreatment of aggressionAdult psychiatric patientsMethod of administrationPsychiatric manifestationsPsychopharmacologic treatmentAppropriate medicationNeurologic conditionsAggressive patientsPatientsMedicationsDiagnostic assessmentAntipsychoticsTreatmentBenzodiazepinesRelevant literatureCliniciansAdministration
1993
Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder
Yehuda R, Southwick SM, Krystal JH, Bremner D, Charney DS, Mason JW. Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. American Journal Of Psychiatry 1993, 150: 83-86. PMID: 8417586, DOI: 10.1176/ajp.150.1.83.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderDexamethasone administrationDexamethasone levelsLow-dose dexamethasone suppression testEnhanced negative feedback sensitivityStress disorderBaseline blood samplesDexamethasone suppression testNegative feedback sensitivityMale patientsHPA abnormalitiesSuppression testMajor depressionBlood samplesLow doseDiagnostic criteriaNormal subjectsPTSD patientsPatientsDexamethasoneCortisolGreater suppressionFeedback sensitivityEnhanced suppressionAdministration
1991
Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration
Rasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.Peer-Reviewed Original ResearchConceptsAcid administrationKynurenic acidSubcutaneous administrationPeripheral excitatory amino acid receptorsExcitatory amino acid antagonist kynurenic acidExcitatory amino acid receptorsAntagonist kynurenic acidExcitatory amino acidsAmino acid receptorsLocus coeruleus neuronsMorphine-dependent ratsBlood-brain barrierSingle-unit recordingsMorphine withdrawalCoeruleus neuronsAntagonist treatmentAbstinence symptomsOpiate withdrawalUnit recordingsAnesthetized animalsAcid receptorsBehavioral signsAdministrationDifferential effectsWithdrawal
1989
Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys
Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.Peer-Reviewed Original ResearchConceptsOpiate withdrawal syndromeInjection of naloxoneWithdrawal syndromeTreatment periodNaloxone injectionNaloxone administrationWithdrawal responsePhysical dependenceDays of methadoneAntagonist exposureMethadone treatmentDaily injectionsLack of incrementReceptor mechanismsDrug combinationsNaloxoneRhesus monkeysSyndromeDay 16MethadoneSame monkeysManagement of situationsInjectionAdministrationDays
1983
A preliminary description of acute physical dependence on morphine in the vervet monkey
Krystal JH, Redmond DE. A preliminary description of acute physical dependence on morphine in the vervet monkey. Pharmacology Biochemistry And Behavior 1983, 18: 289-291. PMID: 6682230, DOI: 10.1016/0091-3057(83)90379-9.Peer-Reviewed Original ResearchConceptsAcute physical dependencePhysical dependencePrevious animal studiesDevelopment of dependenceIntravenous morphineOpioid withdrawalOpiate dependencyNaloxone administrationNonhuman primate subjectsSyndrome characteristicsAnimal studiesMorphinePrimate subjectsVervet monkeysHoursMonkeysOpioidsPrimate speciesAdministration