1991
Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats
Taylor J, Lewis V, Elsworth J, Pivirotto P, Roth R, Redmond D. Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats. Psychopharmacology 1991, 103: 407-414. PMID: 2057541, DOI: 10.1007/bf02244297.Peer-Reviewed Original ResearchConceptsChronic morphine administrationTail-flick latencyMorphine treatmentMorphine administrationMorphine withdrawalNoradrenergic activityAlpha 2 antagonist yohimbineAlpha-2 adrenergic receptorsTail-flick analgesiaChronic drug treatmentNaloxone-precipitated withdrawalDose-dependent mannerAdrenergic hyperactivityOpioid administrationOpioid analgesiaFlick latencyNeuronal hyperactivityMorphine pelletsWithdrawal signsAbnormal postureNoradrenergic systemPenile erectionSaline controlsDrug treatmentAnalgesia
1986
Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain
Elsworth J, Redmond D, Roth R. Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain. Biochemical Pharmacology 1986, 35: 3415-3417. PMID: 3768031, DOI: 10.1016/0006-2952(86)90447-8.Peer-Reviewed Original Research
1982
Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates
Elsworth J, Redmond D, Roth R. Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates. Brain Research 1982, 235: 115-124. PMID: 7188317, DOI: 10.1016/0006-8993(82)90200-1.Peer-Reviewed Original ResearchConceptsConcentration of MHPGBrain areasNorepinephrine metabolismMHPG concentrationsCisternal CSFBrain norepinephrine metabolismFree MHPG concentrationsCentral noradrenergic activityNoradrenergic activityOccipital cortexFree MHPGMHPGBrain regionsCSFSignificant correlationUseful indexVervet monkeysMetabolismPlasmaCortex