2017
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing
Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 2017, 550: 119-123. PMID: 28953873, PMCID: PMC5718149, DOI: 10.1038/nature24022.Peer-Reviewed Original ResearchAdipocytesAdipose TissueAgingAnimalsCaspase 1CatecholaminesGene Expression ProfilingGene Expression RegulationGrowth Differentiation Factor 3InflammasomesLipaseLipolysisMacrophagesMiceMonoamine OxidaseMonoamine Oxidase InhibitorsNLR Family, Pyrin Domain-Containing 3 ProteinNorepinephrineSterol Esterase
1986
Equol and other compounds from bovine urine as monoamine oxidase inhibitors
Dewar D, Glover V, Elsworth J, Sandler M. Equol and other compounds from bovine urine as monoamine oxidase inhibitors. Journal Of Neural Transmission 1986, 65: 147-150. PMID: 3009710, DOI: 10.1007/bf01256490.Peer-Reviewed Original ResearchAnimalsBenzopyransCattleChromansDietEquolIn Vitro TechniquesIsoflavonesLiverMonoamine Oxidase InhibitorsRatsReceptors, GABA-APurification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding
Elsworth J, Dewar D, Glover V, Goodwin B, Clow A, Sandler M. Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding. Journal Of Neural Transmission 1986, 67: 45-56. PMID: 3023548, DOI: 10.1007/bf01243358.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainChromatography, High Pressure LiquidChromatography, Thin LayerHumansIn Vitro TechniquesIsatinLiverMolecular WeightMonoamine Oxidase InhibitorsRadioligand AssayRatsReceptors, GABA-AConceptsRo-15 1788Benzodiazepine receptor antagonistBenzodiazepine receptor agonistsBenzodiazepine receptor bindingPeripheral benzodiazepine receptor ligandsBenzodiazepine receptor ligandsReceptor antagonistPeripheral receptorsReceptor agonistReceptor bindingEndogenous inhibitorMonoamine oxidaseReceptor ligandsRat liverMAO ATyramine oxidationHuman urineLow molecular weight fractionThin-layer chromatographyTribulinAgonistsAntagonistGABABenzodiazepinesLiver
1985
Tribulin: an endogenous monoamine oxidase inhibitor/benzodiazepine receptor ligand.
Sandler M, Glover V, Clow A, Elsworth J. Tribulin: an endogenous monoamine oxidase inhibitor/benzodiazepine receptor ligand. Progress In Clinical And Biological Research 1985, 192: 359-62. PMID: 3001762.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyHumansIsatinMonoamine Oxidase InhibitorsPanicReceptors, GABA-AStress, PsychologicalConceptsLactate-induced panic attacksBenzodiazepine receptor bindingBenzodiazepine receptor ligandsBenzodiazepine withdrawalBenzodiazepine receptorsLow molecular weight inhibitorsPanic attacksTribulin outputAnxiety disordersReceptor bindingMonoamine oxidaseReceptor ligandsAnimal brainsWeight inhibitorsHuman plasmaInhibitorsHuman urineTribulinMonoaminesBrainReceptorsUrine
1984
Ethanol and endogenous ligands in humans.
Sandler M, Glover V, Elsworth J, Clow A. Ethanol and endogenous ligands in humans. Psychopharmacology Bulletin 1984, 20: 485-6. PMID: 6089251.Peer-Reviewed Original Research
1978
Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’
Elsworth J, Glover V, Reynolds G, Sandler M, Lees A, Phuapradit P, Shaw K, Stern G, Kumar P. Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’. Psychopharmacology 1978, 57: 33-38. PMID: 96466, DOI: 10.1007/bf00426954.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood PlateletsCheeseFemaleHumansHypertensionIntestinal MucosaMaleMiddle AgedMonoamine Oxidase InhibitorsParkinson DiseasePhenethylaminesTime FactorsTyramineConceptsMonoamine oxidase B inhibitorsSelective monoamine oxidase B inhibitorNormal dietCheese effectB inhibitorHuman intestinal mucosaNormal human intestinal mucosaPressor responseOral tyraminePressor reactionDeprenyl administrationAdverse reactionsMonoamine oxidase AIntestinal mucosaOxidase AHuman plateletsPlatelet enzymeDeprenylComplete inhibitionVolunteersDietTyramineInhibitorsMucosaAdministration
1977
DEPRENYL IN PARKINSON'S DISEASE
Lees A, Kohout L, Shaw K, Stern G, Elsworth J, Sandler M, Youdim M. DEPRENYL IN PARKINSON'S DISEASE. The Lancet 1977, 310: 791-795. PMID: 71602, DOI: 10.1016/s0140-6736(77)90725-5.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDouble-blind crossover trialDoses of levodopaEarly morning akinesiaPeripheral decarboxylase inhibitorLevodopa-induced dyskinesiaTotal daily dosesMajority of patientsIdiopathic Parkinson's diseaseDose akinesiaUntreated patientsCrossover trialDosage reductionDaily dosesDecarboxylase inhibitorTherapeutic effectCheese effectLarge dosesPatientsLevodopaAlternate daysAkinesiaDeprenylDiseaseB inhibitor