1999
Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys
Jentsch J, Taylor J, Redmond Jr D, Elsworth J, Youngren K, Roth R. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology 1999, 142: 78-84. PMID: 10102786, DOI: 10.1007/s002130050865.Peer-Reviewed Original ResearchConceptsFrontostriatal systemCognitive functionPrefrontal cortexObject retrieval taskRegulation of cognitionPrimate prefrontal cortexD4 dopamine receptorsNormal control monkeysDR antagonistsCognitive processesDetour taskCognitive deficitsPerformance impairmentBrain regionsCognitive dysfunctionRetrieval tasksFrontal cortexTaskCortexCortical dopaminergicDeficitsDopaminergic systemAntagonist reversalControl subjectsDopamine receptors
1996
Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate
Deutch A, Lewis D, Whitehead R, Elsworth J, Iadarola M, Redmond D, Roth R. Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate. Synapse 1996, 23: 182-191. PMID: 8807746, DOI: 10.1002/(sici)1098-2396(199607)23:3<182::aid-syn7>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsFos-LI neuronsExtrapyramidal side effectsEffective antipsychotic drugAntipsychotic drugsEntorhinal cortexSide effectsReceptor antagonistFos expressionD2 receptorsCaudate nucleusNucleus accumbensTemporal cortexFos-like immunoreactive neuronsExtra-pyramidal side effectsD2 dopamine receptor antagonistRat striatal complexC-fosD2 receptor antagonismDorsolateral caudate nucleusDopamine receptor antagonistEffect of administrationImmediate early gene c-fosD2 receptor antagonistEarly gene c-fosFos protein expression
1992
Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates
Innis R, Malison R, Al‐Tikriti M, Hoffer P, Sybirska E, Seibyl J, Zoghbi S, Baldwin R, Laruelle M, Smith E, Charney D, Heninger G, Elsworth J, Roth R. Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates. Synapse 1992, 10: 177-184. PMID: 1532675, DOI: 10.1002/syn.890100302.Peer-Reviewed Original ResearchConceptsBrain uptakeD2 receptorsD2 receptor antagonist haloperidolSpecific brain uptakeStriatal dopamine levelsAdministration of haloperidolReceptor antagonist haloperidolReceptor antagonist propertiesEndogenous neurotransmitter dopamineNonhuman primate experimentsRate of washoutSingle photon emissionDopamine receptor radioligandReserpine pretreatmentEndogenous dopamineAntagonist haloperidolDopamine levelsD-amphetamineAntagonist propertiesNormothermic conditionsMin postinjectionReceptor radioligandRadioligand bindingEndogenous storesRadiotracer binding