1983
Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine
Ko G, Elsworth J, Roth R, Rifkin B, Leigh H, Redmond D. Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine. JAMA Psychiatry 1983, 40: 425-430. PMID: 6838322, DOI: 10.1001/archpsyc.1983.01790040079011.Peer-Reviewed Original ResearchConceptsPlasma MHPG levelsMHPG levelsEffects of clonidineSignificant symptom reductionPlasma MHPG concentrationSelf-rated anxietyPlacebo treatmentCrossover trialMHPG concentrationsPlasma levelsNoradrenergic activityDrug treatmentDrug trialsSymptom reductionDiminished suppressionPanic attacksPanic symptomsImipramine hydrochlorideClonidinePatientsPhobic stimuliImipramineTrialsAnxietyTreatmentRelative Importance of 3‐Methoxy‐4‐Hydroxyphenylglycol and 3,4‐Dihydroxyphenylglycol as Norepinephrine Metabolites in Rat, Monkey, and Humans
Elsworth J, Roth R, Redmond D. Relative Importance of 3‐Methoxy‐4‐Hydroxyphenylglycol and 3,4‐Dihydroxyphenylglycol as Norepinephrine Metabolites in Rat, Monkey, and Humans. Journal Of Neurochemistry 1983, 41: 786-793. PMID: 6875564, DOI: 10.1111/j.1471-4159.1983.tb04809.x.Peer-Reviewed Original ResearchConceptsBrain MHPGNorepinephrine metabolismDHPG concentrationsRat brainConcentration of MHPGPlasma of primatesMonkey CSFAcute administrationNorepinephrine metabolitePrimate CNSMHPGMonkey brainDihydroxyphenylglycolGas chromatographic-mass spectrometric assayUnconjugated formRatsBrainPiperoxaneSignificant correlationDesipramineHigher proportionHuman plasmaMonkeysMetabolitesMetabolism
1982
Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates
Elsworth J, Redmond D, Roth R. Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates. Brain Research 1982, 235: 115-124. PMID: 7188317, DOI: 10.1016/0006-8993(82)90200-1.Peer-Reviewed Original ResearchConceptsConcentration of MHPGBrain areasNorepinephrine metabolismMHPG concentrationsCisternal CSFBrain norepinephrine metabolismFree MHPG concentrationsCentral noradrenergic activityNoradrenergic activityOccipital cortexFree MHPGMHPGBrain regionsCSFSignificant correlationUseful indexVervet monkeysMetabolismPlasmaCortex