2023
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain
Jamwal S, Blackburn J, Elsworth J. Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain. Biology Of Sex Differences 2023, 14: 65. PMID: 37770961, PMCID: PMC10540392, DOI: 10.1186/s13293-023-00551-6.Peer-Reviewed Original ResearchConceptsSubstantia nigraSex-dependent expressionPrimate brainAdult male monkeysCerebrospinal fluidMale monkeysPeroxisome proliferator-activated receptor gamma agonistProliferator-activated receptor gamma agonistsEffect of pioglitazoneWeeks of treatmentReceptor gamma agonistsGreater expressionAdult female monkeysNonhuman primate brainNovel neuroprotective treatmentAfrican green monkeysSex-based differencesOral pioglitazoneNeuroprotective treatmentPIO treatmentRisk factorsCNS disordersGamma agonistsPreclinical studiesParkinson's disease
2021
Expression of PON2 isoforms varies among brain regions in male and female African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Expression of PON2 isoforms varies among brain regions in male and female African green monkeys. Free Radical Biology And Medicine 2021, 178: 215-218. PMID: 34890766, PMCID: PMC8760629, DOI: 10.1016/j.freeradbiomed.2021.12.005.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParkinson's diseaseBrain regionsParaoxonase 2Different brain regionsFemale monkeysGreen monkeysPON2 expressionOxidative stress-related neurodegenerative disordersFemale African green monkeysNeurodegenerative disordersMale African green monkeysOxidative stressPON2 protein expressionAnti-inflammatory propertiesExpression levelsSignificant differencesBrain tissue samplesDorsolateral prefrontal cortexNeuroprotective strategiesWestern blotting techniquesDopaminergic neuronsPON2 proteinPrimate brainProtective rolePioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders
Blackburn JK, Jamwal S, Wang W, Elsworth JD. Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders. Neurochemistry International 2021, 152: 105222. PMID: 34767873, PMCID: PMC8712400, DOI: 10.1016/j.neuint.2021.105222.Peer-Reviewed Original ResearchConceptsPON2 expressionParkinson's diseaseParaoxonase 2Male African green monkeysShort-term animal modelsOxidative stressPeroxisome proliferator-activated receptor gammaEffect of pioglitazoneWeeks of treatmentProliferator-activated receptor gammaNonhuman primate brainParaoxonase-2 expressionRegion-dependent expressionSex-specific therapeuticsAnti-diabetic drug pioglitazoneAfrican green monkeysDorsolateral prefrontal cortexOral pioglitazonePreclinical evidenceSubstantia nigraClinical trialsPON2 mRNAAnimal modelsPioglitazonePrimate brainSex-based disparity in paraoxonase-2 expression in the brains of African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys. Free Radical Biology And Medicine 2021, 167: 201-204. PMID: 33722626, PMCID: PMC8096713, DOI: 10.1016/j.freeradbiomed.2021.03.003.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParaoxonase 2Parkinson's diseaseBrain regionsGreen monkeysOxidative stressReactive oxygen speciesAnti-inflammatory propertiesSex-based disparitiesParaoxonase-2 expressionDifferent brain regionsNigrostriatal systemPON2 expressionDevelopment of therapeuticsNeurodegenerative disordersDiseaseProtein levelsROS levelsLower ROS levelsMitochondrial performanceSex-based variationDisordersMonkeysOxygen speciesMales
2020
Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism
Blackburn JK, Curry DW, Thomsen AN, Roth RH, Elsworth JD. Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism. Experimental Neurology 2020, 327: 113234. PMID: 32044330, PMCID: PMC7089823, DOI: 10.1016/j.expneurol.2020.113234.Peer-Reviewed Original ResearchConceptsParaoxonase 2Novel neuroprotective mechanismParaoxonase-2 expressionAnti-diabetic drug pioglitazoneReactive oxygen species productionNeuroprotective strategiesNeuroprotective mechanismsBrain traumaMouse striatumOxygen species productionParkinson's diseaseAlzheimer's diseaseTherapeutic potentialPioglitazoneDiseaseOxidative stressDrug pioglitazoneSpecies productionBrainNeuroprotectionIschemiaStriatumExpressionPathologyTrauma
2000
The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat
Morrow B, Redmond A, Roth R, Elsworth J. The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat. Brain Research 2000, 864: 146-151. PMID: 10793199, DOI: 10.1016/s0006-8993(00)02174-0.Peer-Reviewed Original ResearchConceptsDopamine metabolismSerum corticosteroneAcute exposureCentral dopamine metabolismNucleus accumbens coreMedial prefrontal cortexFear-inducing behaviorPredator odorCentral effectsAccumbens coreRatsStressful stimuliPrefrontal cortexConditioned fearAltered behaviorControl odorAversive stimuliCorticosteroneMetabolismOpen fieldBiochemical activationUnique patternExposureActivationTMT
1997
Identification of Novel Variants oftrkC mRNA Transcripts in Brain of African Green Monkeys
Tam S, Elsworth J, Sladek J, Redmond D, Roth R. Identification of Novel Variants oftrkC mRNA Transcripts in Brain of African Green Monkeys. Experimental Neurology 1997, 143: 172-176. PMID: 9000456, DOI: 10.1006/exnr.1996.6338.Peer-Reviewed Original ResearchConceptsReverse transcriptase-polymerase chain reactionAfrican green monkeysHigh-affinity neurotrophin receptorsGreen monkeysVentral tegmental areaAdult substantia nigraTranscriptase-polymerase chain reactionMonkey midbrainTrkC mRNAFetal monkeysSubstantia nigraTegmental areaVentral midbrainNeurotrophin receptorFetal brainAdult monkeysCodon 361Receptor tyrosine kinasesTrk familyTrkCDistinct biological effectsChain reactionMonkeysTrkBMidbrain
1993
Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and Serotonin
Bradberry C, Nobiletti J, Elsworth J, Murphy B, Jatlow P, Roth R. Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and Serotonin. Journal Of Neurochemistry 1993, 60: 1429-1435. PMID: 8455033, DOI: 10.1111/j.1471-4159.1993.tb03305.x.Peer-Reviewed Original Research
1992
Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates
Innis R, Malison R, Al‐Tikriti M, Hoffer P, Sybirska E, Seibyl J, Zoghbi S, Baldwin R, Laruelle M, Smith E, Charney D, Heninger G, Elsworth J, Roth R. Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates. Synapse 1992, 10: 177-184. PMID: 1532675, DOI: 10.1002/syn.890100302.Peer-Reviewed Original ResearchConceptsBrain uptakeD2 receptorsD2 receptor antagonist haloperidolSpecific brain uptakeStriatal dopamine levelsAdministration of haloperidolReceptor antagonist haloperidolReceptor antagonist propertiesEndogenous neurotransmitter dopamineNonhuman primate experimentsRate of washoutSingle photon emissionDopamine receptor radioligandReserpine pretreatmentEndogenous dopamineAntagonist haloperidolDopamine levelsD-amphetamineAntagonist propertiesNormothermic conditionsMin postinjectionReceptor radioligandRadioligand bindingEndogenous storesRadiotracer binding
1990
Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam
Gruen R, Elsworth J, Roth R. Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam. Brain Research 1990, 514: 151-154. PMID: 2162709, DOI: 10.1016/0006-8993(90)90449-l.Peer-Reviewed Original ResearchConceptsLow-affinity GABAA receptorsPerinatal exposureGABAA receptorsAbility of GABAPerinatal periodAdult ratsBenzodiazepine receptorsCingulate cortexLow affinity formDiazepamSpecific alterationsSignificant decreaseReceptorsSignificant reductionExposureAffinity formAlterationsHypothalamusGABARatsCortex
1988
Chapter 64 Fetal dopamine neural grafts: extended reversal of methylphenyltetrahydropyridine-induced parkinsonism in monkeys
Sladek J, Redmond D, Collier T, Blount J, Elsworth J, Taylor J, Roth R. Chapter 64 Fetal dopamine neural grafts: extended reversal of methylphenyltetrahydropyridine-induced parkinsonism in monkeys. Progress In Brain Research 1988, 78: 497-506. PMID: 3266802, DOI: 10.1016/s0079-6123(08)60323-4.Peer-Reviewed Original ResearchConceptsDopamine neuronsTherapeutic interventionsHuman parkinsonismHost brainFunctional recoveryDopaminergic neuronsSubstantia nigraCell graftsDopamine levelsFetal brainGraft siteTrophic factorsHuman neuronsAnatomical substrateParkinsonismCerebellar tissueControl transplantsNeuronsGraftBrain activityPhenotype characteristicBrainInterventionTransplantationTransplant
1987
Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism
Sladek J, Redmond D, Collier T, Haber S, Elsworth J, Deutch A, Roth R. Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Progress In Brain Research 1987, 71: 309-323. PMID: 3495818, DOI: 10.1016/s0079-6123(08)61833-6.Peer-Reviewed Original ResearchConceptsParkinsonian signsFetal neuronsCerebrospinal fluidTyrosine hydroxylase-positive neuronsFetal dopamine neuronsToxin-induced parkinsonismDopamine metabolite levelsAfrican green monkeysNigral tissuePositive neuronsGestational tissuesNeurochemical indicesSubstantia nigraDopamine neuronsGrowth of neuritesCaudate nucleusMotor impairmentParkinson's diseaseSevere symptomsPrimate brainThird monkeyImmunohistochemical observationsTransplantationGreen monkeysTherapeutic insights
1986
Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding
Elsworth J, Dewar D, Glover V, Goodwin B, Clow A, Sandler M. Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding. Journal Of Neural Transmission 1986, 67: 45-56. PMID: 3023548, DOI: 10.1007/bf01243358.Peer-Reviewed Original ResearchConceptsRo-15 1788Benzodiazepine receptor antagonistBenzodiazepine receptor agonistsBenzodiazepine receptor bindingPeripheral benzodiazepine receptor ligandsBenzodiazepine receptor ligandsReceptor antagonistPeripheral receptorsReceptor agonistReceptor bindingEndogenous inhibitorMonoamine oxidaseReceptor ligandsRat liverMAO ATyramine oxidationHuman urineLow molecular weight fractionThin-layer chromatographyTribulinAgonistsAntagonistGABABenzodiazepinesLiver
1983
Relative Importance of 3‐Methoxy‐4‐Hydroxyphenylglycol and 3,4‐Dihydroxyphenylglycol as Norepinephrine Metabolites in Rat, Monkey, and Humans
Elsworth J, Roth R, Redmond D. Relative Importance of 3‐Methoxy‐4‐Hydroxyphenylglycol and 3,4‐Dihydroxyphenylglycol as Norepinephrine Metabolites in Rat, Monkey, and Humans. Journal Of Neurochemistry 1983, 41: 786-793. PMID: 6875564, DOI: 10.1111/j.1471-4159.1983.tb04809.x.Peer-Reviewed Original ResearchConceptsBrain MHPGNorepinephrine metabolismDHPG concentrationsRat brainConcentration of MHPGPlasma of primatesMonkey CSFAcute administrationNorepinephrine metabolitePrimate CNSMHPGMonkey brainDihydroxyphenylglycolGas chromatographic-mass spectrometric assayUnconjugated formRatsBrainPiperoxaneSignificant correlationDesipramineHigher proportionHuman plasmaMonkeysMetabolitesMetabolism
1982
Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.
Roth R, Elsworth J, Redmond D. Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates. The Journal Of Clinical Psychiatry 1982, 43: 42-6. PMID: 6806253.Peer-Reviewed Original ResearchConceptsBrain levelsMHPG accumulationNE turnoverNE neuronsLocus coeruleusNaloxone-insensitive mechanismAdministration of naloxoneMorphine-dependent animalsNE systemDose-dependent degreeNon-human primatesNE metabolismMorphine withdrawalOpiate withdrawalClonidine suppressionImpulse flowNoradrenergic hyperactivityClinical studiesCSF measuresControl monkeysClonidineElectrophysiological studiesMHPGBiochemical measuresPilot dataPlasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates
Elsworth J, Redmond D, Roth R. Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates. Brain Research 1982, 235: 115-124. PMID: 7188317, DOI: 10.1016/0006-8993(82)90200-1.Peer-Reviewed Original ResearchConceptsConcentration of MHPGBrain areasNorepinephrine metabolismMHPG concentrationsCisternal CSFBrain norepinephrine metabolismFree MHPG concentrationsCentral noradrenergic activityNoradrenergic activityOccipital cortexFree MHPGMHPGBrain regionsCSFSignificant correlationUseful indexVervet monkeysMetabolismPlasmaCortex
1980
Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man
Glover V, Elsworth J, Sandler M. Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man. Journal Of Neural Transmission. Supplementa 1980, 163-172. PMID: 6776235, DOI: 10.1007/978-3-7091-8582-7_18.Peer-Reviewed Original Research