1992
Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates
Innis R, Malison R, Al‐Tikriti M, Hoffer P, Sybirska E, Seibyl J, Zoghbi S, Baldwin R, Laruelle M, Smith E, Charney D, Heninger G, Elsworth J, Roth R. Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates. Synapse 1992, 10: 177-184. PMID: 1532675, DOI: 10.1002/syn.890100302.Peer-Reviewed Original ResearchConceptsBrain uptakeD2 receptorsD2 receptor antagonist haloperidolSpecific brain uptakeStriatal dopamine levelsAdministration of haloperidolReceptor antagonist haloperidolReceptor antagonist propertiesEndogenous neurotransmitter dopamineNonhuman primate experimentsRate of washoutSingle photon emissionDopamine receptor radioligandReserpine pretreatmentEndogenous dopamineAntagonist haloperidolDopamine levelsD-amphetamineAntagonist propertiesNormothermic conditionsMin postinjectionReceptor radioligandRadioligand bindingEndogenous storesRadiotracer binding
1990
Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam
Gruen R, Elsworth J, Roth R. Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam. Brain Research 1990, 514: 151-154. PMID: 2162709, DOI: 10.1016/0006-8993(90)90449-l.Peer-Reviewed Original ResearchConceptsLow-affinity GABAA receptorsPerinatal exposureGABAA receptorsAbility of GABAPerinatal periodAdult ratsBenzodiazepine receptorsCingulate cortexLow affinity formDiazepamSpecific alterationsSignificant decreaseReceptorsSignificant reductionExposureAffinity formAlterationsHypothalamusGABARatsCortexInteraction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens
Berger P, Elsworth J, Arroyo J, Roth R. Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens. European Journal Of Pharmacology 1990, 177: 91-94. PMID: 1967129, DOI: 10.1016/0014-2999(90)90554-j.Peer-Reviewed Original Research
1980
Tele-methylhistamine is a specific MAO B substrate in man
Elsworth J, Glover V, Sandler M. Tele-methylhistamine is a specific MAO B substrate in man. Psychopharmacology 1980, 69: 287-290. PMID: 6774369, DOI: 10.1007/bf00433097.Peer-Reviewed Original Research