1999
The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat
Morrow B, Elsworth J, Rasmusson A, Roth R. The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience 1999, 92: 553-564. PMID: 10408604, DOI: 10.1016/s0306-4522(99)00014-7.Peer-Reviewed Original ResearchConceptsFear conditioningMesoprefrontal dopamine neuronsClassical fear conditioningMedial prefrontal cortexDopamine neuronsFear responsesConditioned fearPrefrontal cortexFearful behaviorNormal extinctionConditioned responsePsychological stressorsRate of extinctionStress-related changesSham-lesioned ratsConditioningFearAcquisition periodDopamine metabolismNucleus accumbensDopamine levelsAcquisitionRatsNeuronsLesionsAltered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits
Jentsch J, Taylor J, Elsworth J, Redmond D, Roth R. Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits. Neuroscience 1999, 90: 823-832. PMID: 10218783, DOI: 10.1016/s0306-4522(98)00481-3.Peer-Reviewed Original ResearchConceptsCognitive deficitsSubchronic phencyclidine administrationDorsolateral prefrontal cortexFrontal cortexCortical dopamine transmissionReduced dopaminergic functionFrontostriatal functionDetour taskCognitive performanceDopamine utilizationPhencyclidine exposurePrefrontal cortexPerformance impairmentPrelimbic cortexBrain regionsCognitive dysfunctionCortical impairmentCortical regionsCognitive impairmentDopaminergic functionPhencyclidine administrationDopamine transmissionSpecific subregionsCortexPsychotomimetic drug phencyclidine
1997
Phencyclidine Increases Forebrain Monoamine Metabolism in Rats and Monkeys: Modulation by the Isomers of HA966
Jentsch J, Elsworth J, Redmond D, Roth R. Phencyclidine Increases Forebrain Monoamine Metabolism in Rats and Monkeys: Modulation by the Isomers of HA966. Journal Of Neuroscience 1997, 17: 1769-1775. PMID: 9030635, PMCID: PMC6573388, DOI: 10.1523/jneurosci.17-05-01769.1997.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsChlorocebus aethiopsDopamineExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFrontal LobeIsomerismMaleNeuronsPhencyclidineProsencephalonPyrrolidinonesRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSchizophrenic PsychologySerotoninSpecies SpecificitySubstantia NigraTegmentum MesencephaliConceptsPCP-induced increasePrefrontal cortexDA turnoverMonoamine metabolismFrontal cortexNucleus accumbensNMDA receptor antagonist phencyclidinePCP-induced changesForebrain of ratsMonkey frontal cortexEffects of PCPDrug-induced activationMedial prefrontal cortexMonoamine transmissionSerotonergic innervationDopamine innervationSerotonin turnoverDopamine turnoverSerotonin utilizationPsychotomimetic propertiesDopamine transmissionDopamine systemBrain regionsPotent effectsRats
1993
Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and Serotonin
Bradberry C, Nobiletti J, Elsworth J, Murphy B, Jatlow P, Roth R. Cocaine and Cocaethylene: Microdialysis Comparison of Brain Drug Levels and Effects on Dopamine and Serotonin. Journal Of Neurochemistry 1993, 60: 1429-1435. PMID: 8455033, DOI: 10.1111/j.1471-4159.1993.tb03305.x.Peer-Reviewed Original Research
1980
Tele-methylhistamine is a specific MAO B substrate in man
Elsworth J, Glover V, Sandler M. Tele-methylhistamine is a specific MAO B substrate in man. Psychopharmacology 1980, 69: 287-290. PMID: 6774369, DOI: 10.1007/bf00433097.Peer-Reviewed Original ResearchDopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man
Glover V, Elsworth J, Sandler M. Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man. Journal Of Neural Transmission. Supplementa 1980, 163-172. PMID: 6776235, DOI: 10.1007/978-3-7091-8582-7_18.Peer-Reviewed Original Research