1990
3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation
Deutsch A, Elsworth J, Roth R, Menek G. 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation. Brain Research 1990, 527: 96-102. PMID: 2126479, DOI: 10.1016/0006-8993(90)91065-o.Peer-Reviewed Original ResearchConceptsCerebellar motor systemsDopamine innervationOlivocerebellar systemStriatal DA depletionStriatal dopamine innervationStriatal DA concentrationsMotor systemSelective inhibitor deprenylAnteromedial prefrontal cortexDeprenyl pretreatmentStriatal sectorsNigrostriatal degenerationDA innervationDA depletionDA levelsVentromedial striatumMAOB activitySensorimotor functionRats resultsNucleus accumbensDorsolateral aspectDorsolateral striatumMAOA activityDegenerationPrefrontal cortex
1982
The contribution of amphetamine metabolites of (−)-deprenyl to its antiparkinsonian properties
Elsworth J, Sandler M, Lees A, Ward C, Stern G. The contribution of amphetamine metabolites of (−)-deprenyl to its antiparkinsonian properties. Journal Of Neural Transmission 1982, 54: 105-110. PMID: 6809891, DOI: 10.1007/bf01249283.Peer-Reviewed Original Research
1980
The effect of deprenyl, a selective monoamine oxidase B inhibitor, on sleep and mood in man
Thornton C, Doré C, Elsworth J, Herbert M, Stern G. The effect of deprenyl, a selective monoamine oxidase B inhibitor, on sleep and mood in man. Psychopharmacology 1980, 70: 163-166. PMID: 6776576, DOI: 10.1007/bf00435308.Peer-Reviewed Original ResearchConceptsMonoamine oxidase B inhibitorsSelective monoamine oxidase B inhibitorHealthy young male adultsEffect of deprenylSystolic blood pressureB inhibitorBalanced cross-over designStage 2 sleepPlatelet MAO activityYoung male adultsCross-over designPhenylethylamine excretionBlood pressureDrug withdrawalSleep disturbancesMovement sleepLevel of alertnessMAO activityMAO inhibitorsSleepMale adultsDrugsSignificant increaseDeprenylPhenylethylamine concentrationsTele-methylhistamine is a specific MAO B substrate in man
Elsworth J, Glover V, Sandler M. Tele-methylhistamine is a specific MAO B substrate in man. Psychopharmacology 1980, 69: 287-290. PMID: 6774369, DOI: 10.1007/bf00433097.Peer-Reviewed Original ResearchDopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man
Glover V, Elsworth J, Sandler M. Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man. Journal Of Neural Transmission. Supplementa 1980, 163-172. PMID: 6776235, DOI: 10.1007/978-3-7091-8582-7_18.Peer-Reviewed Original Research
1978
Deprenyl is metabolized to methamphetamine and amphetamine in man.
Reynolds G, Elsworth J, Blau K, Sandler M, Lees A, Stern G. Deprenyl is metabolized to methamphetamine and amphetamine in man. British Journal Of Clinical Pharmacology 1978, 6: 542-544. PMID: 728327, PMCID: PMC1429688, DOI: 10.1111/j.1365-2125.1978.tb00883.x.Peer-Reviewed Original Research