2001
Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration
Connor B, Kozlowski D, Unnerstall J, Elsworth J, Tillerson J, Schallert T, Bohn M. Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration. Experimental Neurology 2001, 169: 83-95. PMID: 11312561, DOI: 10.1006/exnr.2001.7638.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyCarrier ProteinsCocaineCorpus StriatumDisease Models, AnimalDopamineDopamine Plasma Membrane Transport ProteinsGenetic TherapyGenetic VectorsGlial Cell Line-Derived Neurotrophic FactorMaleMembrane GlycoproteinsMembrane Transport ProteinsMicroinjectionsMotor ActivityNerve Growth FactorsNerve Tissue ProteinsNeuronsNeurotransmitter AgentsOxidopamineParkinson Disease, SecondaryPresynaptic TerminalsRatsRats, Inbred F344RNA, MessengerSubstantia NigraTyrosine 3-MonooxygenaseConceptsGlial cell line-derived neurotrophic factorGDNF gene deliverySubstantia nigraDA terminalsDA neuronsNeuronal sproutingGlial cell line-derived neurotrophic factor (GDNF) gene deliveryAmphetamine-induced rotational asymmetryLine-derived neurotrophic factorUnilateral intrastriatal injectionAged rat brainDopaminergic neuronal functionTyrosine hydroxylase mRNADA transporter ligandsNigrostriatal functionStriatal injectionAxonal sproutingDopaminergic terminalsIntrastriatal injectionStriatal denervationDenervated striatumWeeks postlesionNeurotrophic factorNigrostriatal axonsPartial lesions
1997
Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs.
Lidow M, Elsworth J, Goldman-Rakic P. Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs. Journal Of Pharmacology And Experimental Therapeutics 1997, 281: 597-603. PMID: 9103549.Peer-Reviewed Original ResearchConceptsChronic treatmentAntipsychotic drugsPrefrontal cortexReceptor antagonismDopamine receptorsD5 dopamine receptor mRNAD2 dopamine receptor antagonismD2 receptor antagonismDopamine receptor mRNAVehicle control groupTreatment of schizophreniaD1 classD5 dopamine receptorsDopamine receptor antagonismPrimate prefrontal cortexD5 mRNAsDopaminergic receptorsAntipsychotic medicationAntipsychotic efficacyD2 antagonistTherapeutic rangeAntipsychotic activityPharmacological spectrumReceptor mRNARibonuclease protection assaysIdentification of Novel Variants oftrkC mRNA Transcripts in Brain of African Green Monkeys
Tam S, Elsworth J, Sladek J, Redmond D, Roth R. Identification of Novel Variants oftrkC mRNA Transcripts in Brain of African Green Monkeys. Experimental Neurology 1997, 143: 172-176. PMID: 9000456, DOI: 10.1006/exnr.1996.6338.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainChlorocebus aethiopsPolymerase Chain ReactionProtein-Tyrosine KinasesRNA, MessengerConceptsReverse transcriptase-polymerase chain reactionAfrican green monkeysHigh-affinity neurotrophin receptorsGreen monkeysVentral tegmental areaAdult substantia nigraTranscriptase-polymerase chain reactionMonkey midbrainTrkC mRNAFetal monkeysSubstantia nigraTegmental areaVentral midbrainNeurotrophin receptorFetal brainAdult monkeysCodon 361Receptor tyrosine kinasesTrk familyTrkCDistinct biological effectsChain reactionMonkeysTrkBMidbrain