1982
The contribution of amphetamine metabolites of (−)-deprenyl to its antiparkinsonian properties
Elsworth J, Sandler M, Lees A, Ward C, Stern G. The contribution of amphetamine metabolites of (−)-deprenyl to its antiparkinsonian properties. Journal Of Neural Transmission 1982, 54: 105-110. PMID: 6809891, DOI: 10.1007/bf01249283.Peer-Reviewed Original Research
1980
The effect of deprenyl, a selective monoamine oxidase B inhibitor, on sleep and mood in man
Thornton C, Doré C, Elsworth J, Herbert M, Stern G. The effect of deprenyl, a selective monoamine oxidase B inhibitor, on sleep and mood in man. Psychopharmacology 1980, 70: 163-166. PMID: 6776576, DOI: 10.1007/bf00435308.Peer-Reviewed Original ResearchConceptsMonoamine oxidase B inhibitorsSelective monoamine oxidase B inhibitorHealthy young male adultsEffect of deprenylSystolic blood pressureB inhibitorBalanced cross-over designStage 2 sleepPlatelet MAO activityYoung male adultsCross-over designPhenylethylamine excretionBlood pressureDrug withdrawalSleep disturbancesMovement sleepLevel of alertnessMAO activityMAO inhibitorsSleepMale adultsDrugsSignificant increaseDeprenylPhenylethylamine concentrationsTele-methylhistamine is a specific MAO B substrate in man
Elsworth J, Glover V, Sandler M. Tele-methylhistamine is a specific MAO B substrate in man. Psychopharmacology 1980, 69: 287-290. PMID: 6774369, DOI: 10.1007/bf00433097.Peer-Reviewed Original ResearchDopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man
Glover V, Elsworth J, Sandler M. Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man. Journal Of Neural Transmission. Supplementa 1980, 163-172. PMID: 6776235, DOI: 10.1007/978-3-7091-8582-7_18.Peer-Reviewed Original Research
1978
Deprenyl is metabolized to methamphetamine and amphetamine in man.
Reynolds G, Elsworth J, Blau K, Sandler M, Lees A, Stern G. Deprenyl is metabolized to methamphetamine and amphetamine in man. British Journal Of Clinical Pharmacology 1978, 6: 542-544. PMID: 728327, PMCID: PMC1429688, DOI: 10.1111/j.1365-2125.1978.tb00883.x.Peer-Reviewed Original ResearchDeprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’
Elsworth J, Glover V, Reynolds G, Sandler M, Lees A, Phuapradit P, Shaw K, Stern G, Kumar P. Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’. Psychopharmacology 1978, 57: 33-38. PMID: 96466, DOI: 10.1007/bf00426954.Peer-Reviewed Original ResearchConceptsMonoamine oxidase B inhibitorsSelective monoamine oxidase B inhibitorNormal dietCheese effectB inhibitorHuman intestinal mucosaNormal human intestinal mucosaPressor responseOral tyraminePressor reactionDeprenyl administrationAdverse reactionsMonoamine oxidase AIntestinal mucosaOxidase AHuman plateletsPlatelet enzymeDeprenylComplete inhibitionVolunteersDietTyramineInhibitorsMucosaAdministration
1977
DEPRENYL IN PARKINSON'S DISEASE
Lees A, Kohout L, Shaw K, Stern G, Elsworth J, Sandler M, Youdim M. DEPRENYL IN PARKINSON'S DISEASE. The Lancet 1977, 310: 791-795. PMID: 71602, DOI: 10.1016/s0140-6736(77)90725-5.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDouble-blind crossover trialDoses of levodopaEarly morning akinesiaPeripheral decarboxylase inhibitorLevodopa-induced dyskinesiaTotal daily dosesMajority of patientsIdiopathic Parkinson's diseaseDose akinesiaUntreated patientsCrossover trialDosage reductionDaily dosesDecarboxylase inhibitorTherapeutic effectCheese effectLarge dosesPatientsLevodopaAlternate daysAkinesiaDeprenylDiseaseB inhibitor