2023
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain
Jamwal S, Blackburn J, Elsworth J. Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain. Biology Of Sex Differences 2023, 14: 65. PMID: 37770961, PMCID: PMC10540392, DOI: 10.1186/s13293-023-00551-6.Peer-Reviewed Original ResearchConceptsSubstantia nigraSex-dependent expressionPrimate brainAdult male monkeysCerebrospinal fluidMale monkeysPeroxisome proliferator-activated receptor gamma agonistProliferator-activated receptor gamma agonistsEffect of pioglitazoneWeeks of treatmentReceptor gamma agonistsGreater expressionAdult female monkeysNonhuman primate brainNovel neuroprotective treatmentAfrican green monkeysSex-based differencesOral pioglitazoneNeuroprotective treatmentPIO treatmentRisk factorsCNS disordersGamma agonistsPreclinical studiesParkinson's disease
2021
Expression of PON2 isoforms varies among brain regions in male and female African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Expression of PON2 isoforms varies among brain regions in male and female African green monkeys. Free Radical Biology And Medicine 2021, 178: 215-218. PMID: 34890766, PMCID: PMC8760629, DOI: 10.1016/j.freeradbiomed.2021.12.005.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParkinson's diseaseBrain regionsParaoxonase 2Different brain regionsFemale monkeysGreen monkeysPON2 expressionOxidative stress-related neurodegenerative disordersFemale African green monkeysNeurodegenerative disordersMale African green monkeysOxidative stressPON2 protein expressionAnti-inflammatory propertiesExpression levelsSignificant differencesBrain tissue samplesDorsolateral prefrontal cortexNeuroprotective strategiesWestern blotting techniquesDopaminergic neuronsPON2 proteinPrimate brainProtective rolePioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders
Blackburn JK, Jamwal S, Wang W, Elsworth JD. Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders. Neurochemistry International 2021, 152: 105222. PMID: 34767873, PMCID: PMC8712400, DOI: 10.1016/j.neuint.2021.105222.Peer-Reviewed Original ResearchConceptsPON2 expressionParkinson's diseaseParaoxonase 2Male African green monkeysShort-term animal modelsOxidative stressPeroxisome proliferator-activated receptor gammaEffect of pioglitazoneWeeks of treatmentProliferator-activated receptor gammaNonhuman primate brainParaoxonase-2 expressionRegion-dependent expressionSex-specific therapeuticsAnti-diabetic drug pioglitazoneAfrican green monkeysDorsolateral prefrontal cortexOral pioglitazonePreclinical evidenceSubstantia nigraClinical trialsPON2 mRNAAnimal modelsPioglitazonePrimate brain
1987
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF. Brain Research 1987, 415: 293-299. PMID: 3496938, DOI: 10.1016/0006-8993(87)90211-3.Peer-Reviewed Original ResearchConceptsHVA/dopamineVentral tegmental areaMPTP treatmentHomovanillic acidTegmental areaDorsal ventral tegmental areaMesolimbic DA systemCSF homovanillic acidAfrican green monkeysHVA concentrationsNigrostriatal damageMesolimbic systemTetrahydropyridine (MPTP) administrationDA lossNE concentrationCaudate nucleusNucleus accumbensParkinson's diseaseStriatal regionsPrimate brainBaseline levelsVentral partMotor disabilityMPTPGreen monkeysChapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism
Sladek J, Redmond D, Collier T, Haber S, Elsworth J, Deutch A, Roth R. Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Progress In Brain Research 1987, 71: 309-323. PMID: 3495818, DOI: 10.1016/s0079-6123(08)61833-6.Peer-Reviewed Original ResearchConceptsParkinsonian signsFetal neuronsCerebrospinal fluidTyrosine hydroxylase-positive neuronsFetal dopamine neuronsToxin-induced parkinsonismDopamine metabolite levelsAfrican green monkeysNigral tissuePositive neuronsGestational tissuesNeurochemical indicesSubstantia nigraDopamine neuronsGrowth of neuritesCaudate nucleusMotor impairmentParkinson's diseaseSevere symptomsPrimate brainThird monkeyImmunohistochemical observationsTransplantationGreen monkeysTherapeutic insights
1986
Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain
Elsworth J, Redmond D, Roth R. Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain. Biochemical Pharmacology 1986, 35: 3415-3417. PMID: 3768031, DOI: 10.1016/0006-2952(86)90447-8.Peer-Reviewed Original Research