1998
Intrastriatal Grafts From Multiple Donors Do Not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates
Sladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Intrastriatal Grafts From Multiple Donors Do Not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates. Cell Transplantation 1998, 7: 87-96. DOI: 10.1016/s0963-6897(98)00007-4.Peer-Reviewed Original ResearchConceptsDopamine neuronsDouble graftsAdult African green monkeysVentral mesencephalic dopamine neuronsMultiple donorsGrafts of tissueMore dopamine neuronsSymptoms of parkinsonismMesencephalic dopamine neuronsDopamine cell survivalHuman clinical trialsAfrican green monkeysIntrastriatal graftsPositive neuronsTotal numberClinical trialsDopamine levelsCaudate nucleusRecipient animalsGraftGrafted tissueNeuronsGreen monkeysNonhuman primatesDorsoventral extentIntrastriatal Grafts from Multiple Donors do not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates
Sladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Intrastriatal Grafts from Multiple Donors do not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates. Cell Transplantation 1998, 7: 87-96. PMID: 9588591, DOI: 10.1177/096368979800700204.Peer-Reviewed Original ResearchConceptsDopamine neuronsDouble graftsAdult African green monkeysVentral mesencephalic dopamine neuronsMultiple donorsGrafts of tissueMore dopamine neuronsSymptoms of parkinsonismMesencephalic dopamine neuronsDopamine cell survivalHuman clinical trialsAfrican green monkeysIntrastriatal graftsPositive neuronsTotal numberClinical trialsDopamine levelsCaudate nucleusRecipient animalsGraftGrafted tissueNeuronsGreen monkeysNonhuman primatesDorsoventral extent
1987
Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism
Sladek J, Redmond D, Collier T, Haber S, Elsworth J, Deutch A, Roth R. Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Progress In Brain Research 1987, 71: 309-323. PMID: 3495818, DOI: 10.1016/s0079-6123(08)61833-6.Peer-Reviewed Original ResearchConceptsParkinsonian signsFetal neuronsCerebrospinal fluidTyrosine hydroxylase-positive neuronsFetal dopamine neuronsToxin-induced parkinsonismDopamine metabolite levelsAfrican green monkeysNigral tissuePositive neuronsGestational tissuesNeurochemical indicesSubstantia nigraDopamine neuronsGrowth of neuritesCaudate nucleusMotor impairmentParkinson's diseaseSevere symptomsPrimate brainThird monkeyImmunohistochemical observationsTransplantationGreen monkeysTherapeutic insights