2000
TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat
Morrow B, Roth R, Elsworth J. TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat. Brain Research Bulletin 2000, 52: 519-523. PMID: 10974491, DOI: 10.1016/s0361-9230(00)00290-2.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexPrefrontal cortexExploratory behaviorSample taskFamiliar objectsNovel objectsMesoprefrontal dopamine neuronsTrimethylthiazolineMemoryPsychological stressTMT exposureObject recognition methodPredator odorSet of objectsCortexElevated serum corticosteroneDopaminergic inputDopaminergic activityBrief exposureDopaminergic innervationSerum corticosteroneDopamine neuronsDopamine metabolismObjectsRecognition methodDivergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat
Morrow B, Elsworth J, Lee E, Roth R. Divergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat. Synapse 2000, 36: 143-154. PMID: 10767061, DOI: 10.1002/(sici)1098-2396(200005)36:2<143::aid-syn7>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsVentral tegmental areaFos-LITegmental areaMedial prefrontal cortexPutative anxiolyticsBenzodiazepine agonistsStress-induced Fos-like immunoreactivityPartial agonistStress-induced Fos expressionGlycine/NMDA receptorPrefrontal cortexMesoprefrontal dopamine neuronsPutative anxiolytic agentsTH-LI cellsSaline-treated ratsFos-like immunoreactivityAnxiolytic-like actionFos-LI nucleiWeak partial agonistStress-induced increaseFear-inducing behaviorFootshock paradigmAlpha2 agonistsStress-induced activationDopaminergic neurons
1999
The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat
Morrow B, Elsworth J, Rasmusson A, Roth R. The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience 1999, 92: 553-564. PMID: 10408604, DOI: 10.1016/s0306-4522(99)00014-7.Peer-Reviewed Original ResearchConceptsFear conditioningMesoprefrontal dopamine neuronsClassical fear conditioningMedial prefrontal cortexDopamine neuronsFear responsesConditioned fearPrefrontal cortexFearful behaviorNormal extinctionConditioned responsePsychological stressorsRate of extinctionStress-related changesSham-lesioned ratsConditioningFearAcquisition periodDopamine metabolismNucleus accumbensDopamine levelsAcquisitionRatsNeuronsLesionsBiochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats
Morrow B, Elsworth J, Zito C, Roth R. Biochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats. Psychopharmacology 1999, 143: 227-234. PMID: 10353424, DOI: 10.1007/s002130050941.Peer-Reviewed Original ResearchConceptsVentral tegmental areaHA-966Expression sessionsIntra-VTADopamine metabolismTegmental areaGlycine/NMDA receptor complexPrefrontal cortexMesoprefrontal dopamine neuronsAnxiolytic-like effectsAnxiolytic-like actionDopamine cell bodiesNMDA receptor complexWeak partial agonistMedial prefrontal cortexStress-induced activationCannula implantationDopamine neuronsControl ratsLocal injectionPartial agonistRatsCell bodiesPsychological stressorsStress-induced changes
1997
Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia
Jentsch J, Elsworth J, Taylor J, Redmond D, Roth R. Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia. Advances In Pharmacology 1997, 42: 810-814. PMID: 9328021, DOI: 10.1016/s1054-3589(08)60870-4.Peer-Reviewed Original ResearchConceptsPCP administrationAcute PCP administrationNegative symptomsDA systemMesoprefrontal dopamine neuronsSubcortical DA systemsBrains of patientsSchizophrenia-like symptomatologyDevelopment of neuropathologyDistinct behavioral effectsDAergic dysfunctionDA metabolismDAergic functionDopamine neuronsCognitive dysfunctionNovel agentsDeficits of schizophreniaFrontal cortexPsychotomimetic propertiesNeurobiological effectsDopamine systemPositive symptomsPhencyclidine administrationBehavioral effectsAdministration