1988
Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients
Goldstein M, Lieberman A, Helmer E, Koslow M, Ransohoff J, Elsworth J, Roth R, Deutch A. Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Annals Of Neurology 1988, 24: 685-688. PMID: 2904793, DOI: 10.1002/ana.410240517.Peer-Reviewed Original ResearchConceptsBiopsy samplesAdrenal transplantationDopamine functionAutologous adrenal transplantationMetabolite homovanillic acidEnzyme tyrosine hydroxylaseConcentration of dopamineParkinsonian patientsTherapeutic responseHomovanillic acidParkinson's diseaseTyrosine hydroxylasePostmortem valuesBiochemical analysisBiochemical parametersPatientsTransplantationPostmortem changesDisease
1987
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF. Brain Research 1987, 415: 293-299. PMID: 3496938, DOI: 10.1016/0006-8993(87)90211-3.Peer-Reviewed Original ResearchConceptsHVA/dopamineVentral tegmental areaMPTP treatmentHomovanillic acidTegmental areaDorsal ventral tegmental areaMesolimbic DA systemCSF homovanillic acidAfrican green monkeysHVA concentrationsNigrostriatal damageMesolimbic systemTetrahydropyridine (MPTP) administrationDA lossNE concentrationCaudate nucleusNucleus accumbensParkinson's diseaseStriatal regionsPrimate brainBaseline levelsVentral partMotor disabilityMPTPGreen monkeys
1986
Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Deutch A, Elsworth J, Goldstein M, Fuxe K, Redmond D, Sladek J, Roth R. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience Letters 1986, 68: 51-56. PMID: 3487756, DOI: 10.1016/0304-3940(86)90228-4.Peer-Reviewed Original ResearchConceptsA8 regionDA neuronsSubstantia nigraDopamine cell groupsDopaminergic neuronsDopamine neuronsImmunohistochemical examinationPreferential vulnerabilityHomovanillic acidBiochemical assessmentCell groupsMarked depletionNeuronsSame animalsSignificant decreaseMarked lossMPTPStriatumNigraVervet monkeysMidbrainTetrahydropyridine