1996
Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys
Elsworth J, Sladek J, Taylor J, Collier T, Redmond D, Roth R. Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys. Neuroscience 1996, 72: 477-484. PMID: 8737417, DOI: 10.1016/0306-4522(95)00564-1.Peer-Reviewed Original ResearchConceptsFetal ventral mesencephalonVentral mesencephalonCaudate nucleusGraft siteDopamine neuronsDopamine concentrationsBehavioral recoveryTyrosine hydroxylase-positive neuronsHomovanillic acid/dopamine ratioFetal dopamine neuronsGrafted dopamine neuronsIntrastriatal transplantsParkinsonian primatesGrafted neuronsIntrastriatal transplantationGestational ageTransplant proceduresDopamine ratioDopamine productionSignificant elevationNucleus accumbensDopamine systemSham graftsGraftBrain regionsRestoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys. Cell Transplantation 1996, 5: 315-325. DOI: 10.1016/0963-6897(95)02034-9.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatumRestoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys. Cell Transplantation 1996, 5: 315-325. PMID: 8689042, DOI: 10.1177/096368979600500220.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatum
1995
Sham surgery does not ameliorate MPTP-induced behavioral deficits in monkeys
Taylor J, Elsworth J, Sladek J, Collier T, Roth R, Redmond D. Sham surgery does not ameliorate MPTP-induced behavioral deficits in monkeys. Cell Transplantation 1995, 4: 13-26. DOI: 10.1016/0963-6897(94)00035-i.Peer-Reviewed Original ResearchConceptsFetal mesencephalic tissueSubstantia nigra graftsSham surgeryBehavioral improvementMesencephalic tissueBehavioral deficitsAdult male African green monkeysDopamine concentrationsMale African green monkeysFetal dopamine neuronsSystemic MPTP administrationIdiopathic Parkinson's diseaseStriatum of MPTPSham-operated monkeysPostmortem brain tissueAfrican green monkeysMore variable effectsNeuronal synaptic connectionsHost neuronsHost striatumHost brainMPTP administrationGestational ageSubstantia nigraNeuronal effectsSham Surgery does not Ameliorate MPTP-Induced Behavioral Deficits in Monkeys
Taylor J, Elsworth J, Sladek J, Collier T, Roth R, Redmond D. Sham Surgery does not Ameliorate MPTP-Induced Behavioral Deficits in Monkeys. Cell Transplantation 1995, 4: 13-26. PMID: 7728327, DOI: 10.1177/096368979500400105.Peer-Reviewed Original ResearchConceptsFetal mesencephalic tissueSubstantia nigra graftsSham surgeryBehavioral improvementMesencephalic tissueBehavioral deficitsAdult male African green monkeysDopamine concentrationsMale African green monkeysFetal dopamine neuronsSystemic MPTP administrationIdiopathic Parkinson's diseaseStriatum of MPTPSham-operated monkeysPostmortem brain tissueAfrican green monkeysMore variable effectsNeuronal synaptic connectionsHost neuronsHost striatumHost brainMPTP administrationGestational ageSubstantia nigraNeuronal effects
1987
Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism
Sladek J, Redmond D, Collier T, Haber S, Elsworth J, Deutch A, Roth R. Chapter 25 Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Progress In Brain Research 1987, 71: 309-323. PMID: 3495818, DOI: 10.1016/s0079-6123(08)61833-6.Peer-Reviewed Original ResearchConceptsParkinsonian signsFetal neuronsCerebrospinal fluidTyrosine hydroxylase-positive neuronsFetal dopamine neuronsToxin-induced parkinsonismDopamine metabolite levelsAfrican green monkeysNigral tissuePositive neuronsGestational tissuesNeurochemical indicesSubstantia nigraDopamine neuronsGrowth of neuritesCaudate nucleusMotor impairmentParkinson's diseaseSevere symptomsPrimate brainThird monkeyImmunohistochemical observationsTransplantationGreen monkeysTherapeutic insights