1999
Spontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated Monkeys
Taylor J, Elsworth J, Lawrence M, Sladek J, Roth R, Redmond D. Spontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated Monkeys. Experimental Neurology 1999, 158: 214-220. PMID: 10448434, DOI: 10.1006/exnr.1999.7093.Peer-Reviewed Original ResearchConceptsCaudate nucleusConcentration of DAEye blink rateBlink rateDA ratioDopaminergic regulationD1 agonist dihydrexidineDA D2 receptorsDopaminergic neurotoxin MPTPSeverity of parkinsonismSpontaneous eye blink rateSpecific brain regionsAntiparkinsonian effectsDA depletionD2 agonistDopamine D1Dopamine levelsNeurotoxin MPTPD2 receptorsMPTPNormal animalsRostral portionSubcortical regionsBrain regionsVentromedial region
1996
Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate
Deutch A, Lewis D, Whitehead R, Elsworth J, Iadarola M, Redmond D, Roth R. Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate. Synapse 1996, 23: 182-191. PMID: 8807746, DOI: 10.1002/(sici)1098-2396(199607)23:3<182::aid-syn7>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsFos-LI neuronsExtrapyramidal side effectsEffective antipsychotic drugAntipsychotic drugsEntorhinal cortexSide effectsReceptor antagonistFos expressionD2 receptorsCaudate nucleusNucleus accumbensTemporal cortexFos-like immunoreactive neuronsExtra-pyramidal side effectsD2 dopamine receptor antagonistRat striatal complexC-fosD2 receptor antagonismDorsolateral caudate nucleusDopamine receptor antagonistEffect of administrationImmediate early gene c-fosD2 receptor antagonistEarly gene c-fosFos protein expression
1992
Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates
Innis R, Malison R, Al‐Tikriti M, Hoffer P, Sybirska E, Seibyl J, Zoghbi S, Baldwin R, Laruelle M, Smith E, Charney D, Heninger G, Elsworth J, Roth R. Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates. Synapse 1992, 10: 177-184. PMID: 1532675, DOI: 10.1002/syn.890100302.Peer-Reviewed Original ResearchConceptsBrain uptakeD2 receptorsD2 receptor antagonist haloperidolSpecific brain uptakeStriatal dopamine levelsAdministration of haloperidolReceptor antagonist haloperidolReceptor antagonist propertiesEndogenous neurotransmitter dopamineNonhuman primate experimentsRate of washoutSingle photon emissionDopamine receptor radioligandReserpine pretreatmentEndogenous dopamineAntagonist haloperidolDopamine levelsD-amphetamineAntagonist propertiesNormothermic conditionsMin postinjectionReceptor radioligandRadioligand bindingEndogenous storesRadiotracer binding
1991
D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey.
Elsworth J, Lawrence M, Roth R, Taylor J, Mailman R, Nichols D, Lewis M, Redmond D. D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey. Journal Of Pharmacology And Experimental Therapeutics 1991, 259: 595-600. PMID: 1682479.Peer-Reviewed Original ResearchConceptsD2 dopamine receptorsDopamine receptorsSpontaneous blink rateBlink ratePrior administrationSCH 23390D1 agonistPartial D1 agonistSpecific D1 antagonistSpecific D2 antagonistRole of D1Dose-dependent increaseSpontaneous eye blink rateFull D1 agonistSpecific D2 agonistReceptor-selective drugsAfrican green monkeysEye blink rateDopamine agonistsSKF 38393D2 agonistD1 antagonistD2 antagonistReceptor subtypesD2 receptors