2005
Neural Stem Cells Implanted into MPTP-Treated Monkeys Increase the Size of Endogenous Tyrosine Hydroxylase-Positive Cells Found in the Striatum: A Return to Control Measures
Bjugstad K, Redmond D, Teng Y, Elsworth J, Roth R, Blanchard B, Snyder E, Sladek J. Neural Stem Cells Implanted into MPTP-Treated Monkeys Increase the Size of Endogenous Tyrosine Hydroxylase-Positive Cells Found in the Striatum: A Return to Control Measures. Cell Transplantation 2005, 14: 183-192. PMID: 15929553, DOI: 10.3727/000000005783983098.Peer-Reviewed Original ResearchConceptsTyrosine hydroxylase-positive cellsNeural stem cellsHydroxylase-positive cellsSubstantia nigraHuman neural stem cellsParkinson's diseaseHuman NSCsCaudate nucleusEffects of NSCsPresence of NSCsImplanted neural stem cellsRight substantia nigraUntreated control monkeysRight caudate nucleusCell populationsAfrican green monkeysEndogenous cell populationsStem cellsMPTP damageMPTP treatmentStriatal environmentNigrostriatal pathwayDopamine neuronsControl monkeysSelective dopaminergic
1982
Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.
Roth R, Elsworth J, Redmond D. Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates. The Journal Of Clinical Psychiatry 1982, 43: 42-6. PMID: 6806253.Peer-Reviewed Original ResearchConceptsBrain levelsMHPG accumulationNE turnoverNE neuronsLocus coeruleusNaloxone-insensitive mechanismAdministration of naloxoneMorphine-dependent animalsNE systemDose-dependent degreeNon-human primatesNE metabolismMorphine withdrawalOpiate withdrawalClonidine suppressionImpulse flowNoradrenergic hyperactivityClinical studiesCSF measuresControl monkeysClonidineElectrophysiological studiesMHPGBiochemical measuresPilot data