1996
Blockade of FG 7142‐Induced Increased Dopamine Utilization by the Glycine/NMDA Receptor Antagonist (+)‐HA 966
Horger B, Elsworth J, Roth R. Blockade of FG 7142‐Induced Increased Dopamine Utilization by the Glycine/NMDA Receptor Antagonist (+)‐HA 966. Journal Of Neurochemistry 1996, 66: 1959-1962. PMID: 8780023, DOI: 10.1046/j.1471-4159.1996.66051959.x.Peer-Reviewed Original ResearchConceptsDopamine utilizationFG 7142Medial prefrontal cortexNucleus accumbensPrefrontal cortexReceptor antagonistHA-966Shell subdivisionReceptor influencesBenzodiazepine inverse agonist FG 7142Male Sprague-Dawley ratsMedia prefrontal cortexMesoaccumbal dopamine neuronsGlycine/NMDA receptor antagonistGlycine receptor antagonistSaline 15 minNMDA receptor antagonistSprague-Dawley ratsDopamine neuronsVehicle administrationSystemic administrationDihydroxyphenylacetic acidAccumbensMajor metaboliteTissue concentrationsTyrosine enhances behavioral and mesocorticolimbic dopaminergic responses to aversive conditioning
Morrow B, Elsworth J, Roth R. Tyrosine enhances behavioral and mesocorticolimbic dopaminergic responses to aversive conditioning. Synapse 1996, 22: 100-105. PMID: 8787125, DOI: 10.1002/(sici)1098-2396(199602)22:2<100::aid-syn2>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexDopamine metabolismNucleus accumbensNonconditioned controlsPrefrontal cortexDopamine utilizationAdministration of haloperidolExogenous tyrosineBiosynthesis of catecholaminesDopaminergic responseDietary tyrosineRelevant doseAccumbensRatsTyrosine hydroxylationCortexGreater elevationNonconditioned ratsB-carbolineSaline/Test dayMetabolismBehavioral consequencesAversive conditioningTone
1995
Selective Increase in Dopamine Utilization in the Shell Subdivision of the Nucleus Accumbens by the Benzodiazepine Inverse Agonist FG 7142
Horger B, Elsworth J, Roth R. Selective Increase in Dopamine Utilization in the Shell Subdivision of the Nucleus Accumbens by the Benzodiazepine Inverse Agonist FG 7142. Journal Of Neurochemistry 1995, 65: 770-774. PMID: 7616234, DOI: 10.1046/j.1471-4159.1995.65020770.x.Peer-Reviewed Original ResearchConceptsBenzodiazepine inverse agonist FG 7142Dopamine utilizationFG 7142Nucleus accumbensShell subdivisionWhole nucleus accumbensVivo microdialysis studyRats 30 minMedial prefrontal cortexMicrodialysis studyDopamine metabolismDopamine releaseDihydroxyphenylacetic acidAccumbensBrain regionsPrefrontal cortexSelective increaseMajor metaboliteTissue concentrationsPrevious reportsAdministration